Use of human papillomavirus DNA, E6/E7 mRNA, and p16 immunocytochemistry to detect and predict anal high-grade squamous intraepithelial lesions in HIV-positive and HIV-negative men who have sex with men

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Phanuphak, Nittaya ^a,b   Teeratakulpisarn, Nipat ^a   Keelawat, Somboon ^c   Pankam, Tippawan ^a   Barisri, Jiranuwat ^a   Triratanachat, Surang ^c   Deesua, Amornrat ^a   Rodbamrung, Piyanee ^a   Wongsabut, Jiratchaya ^d   Tantbirojn, Patou ^c   Numto, Saranya ^c   Ruangvejvorachai, Preecha ^c   Phanuphak, Praphan ^a,b,c,d   Palefsky, Joel M ^e   Ananworanich, Jintanat ^a,b,c,d   Kerr, Stephen J ^d,f  

^a THAI RED CROSS AIDS RESEARCH CENTRE   (Thailand)

^b SEARCH   (Thailand)

^c CHULALONGKORN UNIVERSITY   (Thailand)

^d THAI RED CROSS AIDS RESEARCH CENTRE   (Thailand)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN E6; PROTEIN E7; PROTEIN P16; VIRUS DNA;

ANUS CARCINOMA; ARTICLE; CANCER INCIDENCE; CELL TRANSFORMATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTODIAGNOSIS; GASTROINTESTINAL ENDOSCOPY; GENOTYPE; HIGH RESOLUTION ANOSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MEN WHO HAVE SEX WITH MEN; PREDICTIVE VALUE; PREVALENCE; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; RECTUM BIOPSY; SENSITIVITY AND SPECIFICITY; WART VIRUS;

ADULT; ANAL CANAL; BIOLOGICAL MARKERS; DNA, VIRAL; EPITHELIAL CELLS; GENOTYPING TECHNIQUES; HIV SERONEGATIVITY; HIV SEROPOSITIVITY; HOMOSEXUALITY, MALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM PROTEINS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS E7 PROTEINS; PREVALENCE; RISK; RNA, MESSENGER;

EID: 84893185920     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078291     Document Type: Article

References (29)

1. D'Souza G, Wiley DJ, Li X, Chmiel JS, Margolick JB, et al. (2008) Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study. J Acquir Immune Defic Syndr 48: 491-499.
2. Watson AJ, Smith BB, Whitehead MR, Sykes PH, Frizelle FA (2006) Malignant progression of anal intra-epithelial neoplasia. ANZ J Surg 76: 715-717. (Pubitemid 44154742)
3. Devaraj B, Cosman BC (2006) Expectant management of anal squamous dysplasia in patients with HIV. Dis Colon Rectum 49: 36-40. (Pubitemid 41830653)
4. Scholefield JH, Castle MT, Watson NF (2005) Malignant transformation of high-grade anal intraepithelial neoplasia. Br J Surg 92: 1133-1136. (Pubitemid 41284878)
5. Palefsky JM, Holly EA, Efirdc JT, Da Costa M, Jay N, et al. (2005) Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS 19: 1407-1414. (Pubitemid 41800677)
6. Chin-Hong PV, Berry JM, Cheng SC, Catania JA, Da Costa M, et al. (2008) Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men. Ann Intern Med 149: 300-306.
7. de Pokomandy A, Rouleau D, Ghattas G, Trottier H, Vezina S, et al. (2011) HAART and progression to high-grade anal intraepithelial neoplasia in men who have sex with men and are infected with HIV. Clin Infect Dis 52: 1174-1181.
8. Palefsky JM, Holly EA, Gonzales J, Berline J, Ahn DK, et al. (1991) Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer. Cancer Res 51: 1014-1019.
9. Palefsky JM, Holly EA, Ralston ML, Jay N, Berry JM, et al. (1998) High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. AIDS 12: 495-503. (Pubitemid 28116159)
10. Salit IE, Tinmouth J, Chong S, Raboud J, Diong C, et al. (2009) Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology. Cancer Epidemiol Biomarkers Prev 18: 1986-1992.
11. Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, et al. (2004) Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer 101: 270-280. (Pubitemid 38890829)
12. Frisch M, Fenger C, van den Brule AJ, Sorensen P, Meijer CJ, et al. (1999) Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. Cancer Res 59: 753-757. (Pubitemid 29076078)
13. Critchlow CW, Surawicz CM, Holmes KK, Kuypers J, Daling JR, et al. (1995) Prospective study of high grade anal squamous intraepithelial neoplasia in a cohort of homosexual men: influence of HIV infection, immunosuppression and human papillomavirus infection. AIDS 9: 1255-1262.
14. Chiao EY, Giordano TP, Palefsky JM, Tyring S, El Serag H (2006) Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review. Clin Infect Dis 43: 223-233.
15. Goldstone SE, Lowe B, Rothmann T, Nazarenko I (2012) Evaluation of the hybrid capture 2 assay for detecting anal high-grade dysplasia. Int J Cancer 131: 1641-1648.
16. Berry JM, Palefsky JM, Jay N, Cheng SC, Darragh TM, et al. (2009) Performance characteristics of anal cytology and human papillomavirus testing in patients with high-resolution anoscopy-guided biopsy of high-grade anal intraepithelial neoplasia. Dis Colon Rectum 52: 239-247.
17. Indinnimeo M, d'Ettorre G, Fiore A, Ceccarelli G, Ciardi A, et al. (2011) Diagnosis of anal human papillomavirus infection: polymerase chain reaction or cytology? Int J Infect Dis 15: e232-235.
18. Roka F, Roka J, Trost A, Schalk H, Zagler C, et al. (2008) Anal human papillomavirus testing with Digene's hybrid capture 2 using two different sampling methods. Dis Colon Rectum 51: 62-66.
19. Silling S, Kreuter A, Hellmich M, Swoboda J, Pfister H, et al. (2012) Human papillomavirus oncogene mRNA testing for the detection of anal dysplasia in HIV-positive men who have sex with men. J Clin Virol 53: 325-331.
20. Valari O, Koliopoulos G, Karakitsos P, Valasoulis G, Founta C, et al. (2011) Human papillomavirus DNA and mRNA positivity of the anal canal in women with lower genital tract HPV lesions: predictors and clinical implications. Gynecol Oncol 122: 505-508.
21. Darragh TM, Birdsong G, Luff R, Davey D In: Solomon D, et al. (2004) The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. 2nd ed. New York: Springer-Verlag.
22. Tamhane A (2008) Matched-sample analysis: sensitivity, specificity, and P values. Clin Infect Dis 46: 474-475; author reply 475.
23. Phanuphak N, Teeratakulpisarn N, Triratanachat S, Keelawat S, Pankam T, et al. (2013) High prevalence and incidence of high-grade anal intraepithelial neoplasia among young Thai men who have sex with men with and without HIV. AIDS 27, online edition: DOI: 101097/QAD0b013e328360a509.
24. Kreuter A, Brockmeyer NH, Hochdorfer B, Weissenborn SJ, Stucker M, et al. (2005) Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol 52: 603-608. (Pubitemid 40585429)
25. van der Snoek EM, van der Ende ME, den Hollander JC, Schutten M, Neumann HA, et al. (2012) Use of highly active antiretroviral therapy is associated with lower prevalence of anal intraepithelial neoplastic lesions and lower prevalence of human papillomavirus in HIV-infected men who have sex with men. Sex Transm Dis 39: 495-500.
26. Wentzensen N, Follansbee S, Borgonovo S, Tokugawa D, Schwartz L, et al. (2012) Human papillomavirus genotyping, human papillomavirus mRNA expression, and p16/Ki-67 cytology to detect anal cancer precursors in HIV-infected MSM. AIDS 26: 2185-2192.
27. Silvera R, Gaisa M, Goldstone S (2013.) Random Biopsy Increases Diagnostic Rate and Total Anal High-grade Squamous Intraepithelial Lesions Found by High-resolution Anoscopy. Presented at: 20th Conference on Retroviruses and Opportunistic Infections.
28. Dray M, Russell P, Dalrymple C, Wallman N, Angus G, et al. (2005) p16(INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical biopsies. Pathology 37: 112-124. (Pubitemid 40593402)
29. Pirog EC, Quint KD, Yantiss RK (2010) P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction. Am J Surg Pathol 34: 1449-1455.