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23661722 10.1161/CIRCULATIONAHA.112.001290 This posthoc analysis of the PARTNER trial demonstrates that patients with low flow have worse outcomes compared to patients with normal flow and that survival of patients with paradoxical low-flow, low-gradient is improved with TAVR compared to medical therapy
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2 is a powerful independent predictor of survival following TAVR, irrespective of gradient or LVEF
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2 is a powerful independent predictor of survival following TAVR, irrespective of gradient or LVEF.
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10.1016/j.jcmg.2012.10.015 This is the first study to demonstrate the usefulness of stress echocardiography to differentiate true from pseudo-severe AS in patients with paradoxical low-flow, low-gradient AS
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10.1161/CIRCULATIONAHA.113.003071 This study further underlines the contribution of hypertension in the pathophysiology of paradoxical low-flow, low-gradient AS and the findings of this study suggest that nitroprusside vasodilation in the cathetertization laboratory may be useful to corroborate the stenosis severity in these patients
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Circulation
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10.1016/j.jacc.2013.08.1621 This is the first study to demonstrate that we need different thresholds of aortic valve calcification in women vs. men to identify severe aortic stenosis
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10.1161/CIRCULATIONAHA.112.001094 This study shows that AVR is associated with major survival benefit compared to medical therapy in patients with paradoxical low-flow, low-gradient as well as in those with normal-flow, low-gradient and small aortic valve area
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Circulation
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