Objectifying the conjunctival provocation test: Photography-based rating and digital analysis

International Archives of Allergy and Immunology

Volumn 163, Issue 1, 2014, Pages 59-68

  Dogan, S ^a   Astvatsatourov, A ^a   Deserno, T M ^b   Bock, F ^a   Shah Hosseini, K ^a   Michels, A ^a   Mosges R ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Allergic rhinoconjunctivitis; Conjunctival provocation test; Digital image analysis; Nasal provocation tests; Photography based rating; Pollen allergens

Indexed keywords

ARTICLE; CONJUNCTIVAL HYPEREMIA; CONJUNCTIVAL PROVOCATION TEST; DIGITAL IMAGING; DIGITAL PHOTOGRAPHY; HUMAN; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MEDICAL PHOTOGRAPHY; PRIORITY JOURNAL; PROVOCATION TEST; ALLERGIC REACTION; COMPUTER PROGRAM; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EYE IRRITATION; EYE PHOTOGRAPHY; IMAGE ANALYSIS; MUCOSAL IRRITATION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

ADULT; ALLERGENS; CLINICAL TRIALS AS TOPIC; COMPLEX MIXTURES; CONJUNCTIVITIS, ALLERGIC; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMMUNOTHERAPY; MALE; MIDDLE AGED; MONITORING, IMMUNOLOGIC; PHOTOGRAPHY; POLLEN; REGRESSION ANALYSIS; RHINITIS, ALLERGIC, SEASONAL; SEVERITY OF ILLNESS INDEX;

EID: 84893089023     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000355333     Document Type: Article

References (67)

1. Lightman S, Scadding GK: Should intranasal corticosteroids be used for the treatment of ocular symptoms of allergic rhinoconjuncti-vitis? A review of their efficacy and safety profile. Int Arch Allergy Immunol 2012; 158:317-325.
2. Bousquet J, Bodez T, Gehano P, Klossek JM, Liard F, Neukirch F, Le Gal M, Janin N, Allaf B: Implementation of guidelines for allergic rhinitis in specialist practices: a randomized pragmatic controlled trial. Int Arch Allergy Immunol 2009; 150:75-82.
3. Han DH, Rhee CS: Sublingual immunothera-py in allergic rhinitis. Asia Pac Allergy 2011; 1:123-129.
4. Shah A: Current trends in upper airways and ocular allergic inflammation. Asia Pac Allergy 2011; 1:105-107.
5. van Hage-Hamsten M, Pauli G: Provocation testing with recombinant allergens. Methods 2004; 32:281-291. (Pubitemid 38201282)
6. Bousquet J, Khaltaev N, Cruz AA, et al: Allergic rhinitis and its impact on asthma (ARIA) 2008. Allergy 2008; 63:8-160.
7. Riechelmann H, Epple B, Gropper G: Comparison of conjunctival and nasal provocation test in allergic rhinitis to house dust mite. Int Arch Allergy Immunol 2003; 130: 51-59. (Pubitemid 36184438)
8. European Medicines Agency: Guideline on the clinical development of medicinal products for the treatment of allergic rhinocon-junctivitis. London, EMA, 2004.
9. Friedlaender MH: Conjunctival provocative tests: a model of human ocular allergy. Trans Am Ophthalmol Soc 1989; 87:577-597. (Pubitemid 20128129)
10. Melillo G, Bonini S, Cocco G, Davies RJ, de Monchy JG, Frolund L, Pelikan Z: EAACI provocation tests with allergens: report prepared by the European Academy of Allergology and Clinical Immunology Subcommittee on provocation tests with allergens. Allergy 1997; 52:1-35.
11. Bachert C, Borchard U, Wedi B, Klimek L, Rasp G, Riechelmann H, Schultze-Werning-haus G, Wahn U, Ring J: Allergic rhinocon-junctivitis. Guidelines of the dgai in association with the ddg (in German). J Dtsch Der-matol Ges 2006; 4:264-275.
12. Leonardi A, Battista MC, Gismondi M, Freg-ona IA, Secchi AG: Antigen sensitivity evaluated by tear-specific and serum-specific IgE, skin tests, and conjunctival and nasal provocation tests in patients with ocular allergic disease. Eye 1993; 7:461-464. (Pubitemid 23247853)
13. Leonardi A, Fregona IA, Gismondi M, Dani-otti E, Carniel G, Secchi AG: Correlation between conjunctival provocation test (CPT) and systemic allergometric tests in allergic conjunctivitis. Eye 1990; 4:760-764.
14. Naclerio RM, Philpot EE: Is conjunctival allergen challenge a model of seasonal rhinoconjunc-tivitis? Allergy Asthma Proc 2009; 30: 212-214.
15. Radcliffe MJ, Lewith GT, Prescott P, Church MK, Holgate ST: Do skin prick and conjunc-tival provocation tests predict symptom severity in seasonal allergic rhinoconjunctivitis? Clin Exp Allergy 2006; 36:1488-1493. (Pubitemid 44902925)
16. Katelaris CH: Ocular allergy in the Asia Pacific region. Asia Pac Allergy 2011; 1:108-114.
17. Bousquet PJ, Demoly P, Devillier P, Mesbah K, Bousquet J: Impact of allergic rhinitis symptoms on quality of life in primary care. Int Arch Allergy Immunol 2013; 160:393-400.
18. Kjaergaard SK, Pedersen OF, Taudorf E, Molhave L: Assessment of changes in eye redness by a photographic method and the relation to sensory eye irritation. Int Arch Occup Environ Health 1990; 62:133-137. (Pubitemid 20069815)
19. Peterson RC, Wolffsohn JS: Sensitivity and reliability of objective image analysis compared to subjective grading of bulbar hyper-aemia. Br J Ophthalmol 2007; 91:1464-1466. (Pubitemid 350044047)
20. Horak F, Berger U, Menapace R, Schuster N: Quantification of conjunctival vascular reaction by digital imaging. J Allergy Clin Immunol 1996; 98:495-500. (Pubitemid 26377913)
21. Wang de Y: Management of allergic rhinitis in general practitioners. Asia Pac Allergy 2012; 2:233-236.
22. Riechelmann H, Bachert C, Goldschmidt O, Hauswald B, Klimek L, Schlenter W W, Tasman AJ, Wagenmann M: Application of the nasal provocation test on diseases of the upper airways. Position paper of the German Society for Allergology and Clinical Immunology (ENT section) in cooperation with the Working Team for Clinical Immunology (in German). Laryn-gorhinootologie 2003; 82: 183-188. (Pubitemid 36437662)
23. Malm L, Gerth van Wijk R, Bachert C: Guidelines for nasal provocations with aspects on nasal patency, airflow, and airflow resistance. International Committee on Objective Assessment of the Nasal Airways, International Rhinologic Society. Rhinology 2000; 38:1-6.
24. Carney A, Bateman N, Jones N: Reliable and reproducible anterior active rhinomanome-try for the assessment of unilateral nasal resistance. Clin Otolaryngol Allied Sci 2001; 25: 499-503. (Pubitemid 32002860)
25. Sipila J, Suonpaa J, Laippala P: Evaluation of nasal resistance data in active anterior rhino-manometry with special reference to clinical usefulness and test-retest analysis. Clinical Otolaryngol Allied Sci 1992; 17:170-177.
26. Thulesius HL, Cervin A, Jessen M: Can we always trust rhinomanometry? Rhinology 2011; 49:46-52.
27. Fukushima A, Tomita T: Image analyses of the kinetic changes of conjunctival hyperemia in histamine-induced conjunctivitis in guinea pigs. Cornea 2009; 28:694-698.
28. Yoneda T, Sumi T, Takahashi A, Hoshikawa Y, Kobayashi M, Fukushima A: Automated hyperemia analysis software: reliability and reproducibility in healthy subjects. Jpn J Oph-thalmol 2012; 56:1-7.
29. Owen CG, Ellis TJ, Woodward EG: A comparison of manual and automated methods of measuring conjunctival vessel widths from photographic and digital images. Ophthalmic Physiol Opt 2004; 24:74-81. (Pubitemid 41711025)
30. Fieguth P, Simpson T: Automated measurement of bulbar redness. Invest Ophthalmol Vis Sci 2002; 43:340-347. (Pubitemid 34113213)
31. Peterson RC, Wolffsohn JS: Objective grading of the anterior eye. Optom Vis Sci 2009; 86: 273-278.
32. Peterson RC, Wolffsohn JS: The effect of digital image resolution and compression on anterior eye imaging. Br J Ophthalmol 2005; 89: 828-830. (Pubitemid 40904803)
33. Wolffsohn J: Incremental nature of anterior eye grading scales determined by objective image analysis. Br J Ophthalmol 2004; 88: 1434-1438. (Pubitemid 39424726)
34. Wolffsohn JS, Purslow C: Clinical monitoring of ocular physiology using digital image analysis. Cont Lens Anterior Eye 2003; 26:27-35. (Pubitemid 36348132)
35. Schulze MM, Hutchings N, Simpson TL: The use of fractal analysis and photometry to estimate the accuracy of bulbar redness grading scales. Invest Ophthalmol Vis Sci 2008; 49: 1398-1406.
36. Papas EB: Key factors in the subjective and objective assessment of conjunctival erythema. Invest Ophthalmol Vis Sci 2000; 41:687-691. (Pubitemid 30158877)
37. Kumar S, Yogesan K, Constable IJ: Telemedi-cal diagnosis of anterior segment eye diseases: validation of digital slit-lamp still images. Eye 2008; 23:652-660.
38. Bock F, Onderka J, Hos D, Horn F, Martus P, Cursiefen C: Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts. Exp Eye Res 2008; 87:462-470.
39. Fallah Tafti MR, Khosravifard K, Moham-madpour M, Hashemian MN, Kiarudi MY: Efficacy of intralesional bevacizumab injection in decreasing pterygium size. Cornea 2011; 30:127-129.
40. Mandalos A, Tsakpinis D, Karayannopoulou G, Tsinopoulos I, Karkavelas G, Chalvatzis N, Dimitrakos S: The effect of subconjunctival ranibizumab on primary pterygium: a pilot study. Cornea 2010; 29:1373-1379.
41. Suner S, Crawford G, McMurdy J, Jay G: Non-invasive determination of hemoglobin by digital photography of palpebral conjunctiva. J Emerg Med 2007; 33:105-111. (Pubitemid 47199023)
42. Weinand F, Jung A, Stein A, Pfützner A, Becker R, Pavlovic S: Rotational stability of a single-piece hydrophobic acrylic intraocular lens: new method for high-precision rotation control. J Cataract Refract Surg 2007; 33:800-803. (Pubitemid 46646979)
43. Kawai M, Yamada M, Kawashima M, Inoue M, Goto E, Mashima Y, Tsubota K: Quantitative evaluation of tear meniscus height from fluorescein photographs. Cornea 2007; 26: 403-406. (Pubitemid 46684378)
44. Manni G, Centofanti M, Parravano M, Odd-one F, Bucci MG: A 6-month randomized clinical trial of bimatoprost 0.03% versus the association of timolol 0.5% and latanoprost 0.005% in glaucomatous patients. Graefes Arch Clin Exp Ophthalmol 2004; 242:767-770. (Pubitemid 39386377)
45. Setaro M, Sparavigna A: Quantification of erythema using digital camera and computer-based colour image analysis: a multicentre study. Skin Res Technol 2002; 8:84-88. (Pubitemid 34692965)
46. dos Santos RV, Titus RG, Lima HC: Objective evaluation of skin prick test reactions using digital photography. Skin Res Technol 2007; 13:148-153. (Pubitemid 46443678)
47. Holm O, Lindell E, Malm L: Colour change in the human histamine wheal made visible by LYYN: a technique to enhance colour differences. Skin Res Technol 2010; 16:385-389.
48. Scherer K, Grize L, Schindler C, Surber C, Bircher AJ: Reaction pattern to histamine and codeine in a human intradermal skin test model. Clin Exp Allergy 2007; 37:39-46. (Pubitemid 46011057)
49. Xing C, Xu A: The effect of combined calci-potriol and betamethasone dipropionate ointment in the treatment of vitiligo: an open, uncontrolled trial. J Drugs Dermatol 2012; 11:e52-e54.
50. Skvara H, Burnett P, Jones J, Duschek N, Plassmann P, Thirion J-P: Quantification of skin lesions with a 3D stereovision camera system: validation and clinical applications. Skin Res Technol 2013; 19:e182-e190.
51. Tremp M, Knafla I, Burg G, Wuethrich B, Schmid-Grendelmeier P: 'EASIdig'-a digital tool to document disease activity in atopic dermatitis. Dermatology 2011; 223:68-73.
52. Emer JJ, Frankel A, Sohn A, Lebwohl M: A bilateral comparison study of pimecrolimus cream 1% and a topical medical device cream in the treatment of patients with atopic dermatitis. J Drugs Dermatol 2011; 10:735-743.
53. Conrad J, Philipps M, Oertel J: High-definition imaging in endoscopic transsphenoidal pituitary surgery. Am J Rhinol Allergy 2011; 25:e13-e17.
54. Klimek L, Mösges R: Computer-assistierte chirurgie (CAS) in der HNO-heilkunde. La-ryngorhinootologie 1998; 77:275-282.
55. Belli J, Chaves T, Oliveira A, Grossi D: Analysis of body posture in children with mild to moderate asthma. Eur J Pediatr 2009; 168: 1207-1216.
56. Ricieri DDV, Rosário NA, Costa JR: Chest diameter ratios for detecting static hyperinflation in children using photogrammetry. J Pe-diatr 2008; 84:410-415.
57. Elbeshbeshy B, Trepman E: Digital photography in orthopaedic surgery. Foot Ankle Int 2001; 22:67-74. (Pubitemid 32107696)
58. Thomas JR, Tardy ME Jr, Przekop H: Uniform photographic documentation in facial plastic surgery. Otolaryngol Clin North Am 1980; 13:367-381. (Pubitemid 10006241)
59. Waite KJ: Blackley and the development of hay fever as a disease of civilization in the nineteenth century. Med Hist 1995; 39:186-196.
60. Chelminska M, Niedoszytko M, Jassem E: Clinical value of conjunctival allergen challenge in diagnosing allergic conjunctivitis related to latex. Int Arch Allergy Immunol 2011; 154:149-154.
61. Ciprandi G, Buscaglia S, Marchesi E, Danzig M, Cuss F, Canonica GW: Protective effect of loratadine on late phase reaction induced by conjunctival provocation test. Int Arch Allergy Immunology 1993; 100:185-189. (Pubitemid 23095959)
62. Eichel A, Rohdenburg C, Shah-Hosseini K, Mösges R: Dose-finding study for the efficacy of lais grass pollen tabletts on patients with grass pollen induced allergic rhinoconjunc-tivits. Allergo J 2012; 21:69.
63. Nagel E, Vilser W, Lanzl I: Online human conjunctival vessel diameter analysis: a clinical-methodical study. Clin Hemorheol Mi-crocirc 2003; 28:221-227. (Pubitemid 36995069)
64. European Medicines Agency: Guideline on the clinical development of products for specific immunotherapy for the treatment of allergic diseases. London, EMA, 2008.
65. Nunez R, Carballada F, Lombardero M, Jime-no L, Boquete M: Profilin as an aeroallergen by means of conjunctival allergen challenge with purified date palm profilin. Int Arch Allergy Immunol 2012; 158:115-119.
66. Abelson MB, Chambers WA, Smith LM: Conjunctival allergen challenge: a clinical approach to studying allergic conjunctivitis. Arch Ophthalmol 1990; 108:84-88. (Pubitemid 20031417)
67. Bista SR, Sárándi I, Dogan S, Astvatsatourov A, Mösges R, Deserno TM: Automatic con-junctival provocation test combining hough circle transform and self-calibrated color measurements. Proc SPIE 2013; 8670:86702J.