Hypermutable Staphylococcus aureus strains present at high frequency in subclinical bovine mastitis isolates are associated with the development of antibiotic resistance

Veterinary Microbiology

Volumn 165, Issue 3-4, 2013, Pages 410-415

  Wang, Shaochen ^a,b,c   Wu, Congming ^a   Shen, Jianzhong ^a   Wu, Yongning ^a,c   Wang, Yang ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c CHINA NATIONAL CENTER FOR FOOD SAFETY RISK ASSESSMENT   (China)

Author keywords

Antibiotic resistance; Bovine subclinical mastitis; Chronic infection; Hypermutation; Staphylococcus aureus

Indexed keywords

AMPICILLIN; CEFTIOFUR; CIPROFLOXACIN; CLINDAMYCIN; ERYTHROMYCIN; FLORFENICOL; PROTEIN MUTL; PROTEIN MUTS; SULFAFURAZOLE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL STRAIN; BACTERIUM ISOLATE; BOVINE MASTITIS; CHRONIC DISEASE; CLINICAL MASTITIS; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; MASTITIS; MISMATCH REPAIR; MOLECULAR EPIDEMIOLOGY; MULTIDRUG RESISTANCE; MUTATION RATE; NONHUMAN; PHENOTYPE; RESPIRATORY TRACT INFECTION; STAPHYLOCOCCUS AUREUS; SUBCLINICAL MASTITIS;

BACTERIA (MICROORGANISMS); BOVINAE; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATTLE; DRUG RESISTANCE, MICROBIAL; FEMALE; MASTITIS, BOVINE; MICROBIAL SENSITIVITY TESTS; MUTATION; MUTATION RATE; MUTS DNA MISMATCH-BINDING PROTEIN; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84893009133     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2013.04.009     Document Type: Article

References (27)

1. Besier S., Zander J., Kahl B.C., Kraiczy P., Brade V., Wichelhaus T.A. The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. Antimicrob. Agents Chemother. 2008, 52:2183-2189.
2. Blazquez J. Hypermutation as a factor contributing to the acquisition of antimicrobial resistance. Clin. Infect. Dis. 2003, 37:1201-1209.
3. Chopra I., O'Neill A.J., Miller K. The role of mutators in the emergence of antibiotic-resistant bacteria. Drug Resist. Updat. 2003, 6:137-145.
4. Ciofu O., Riis B., Pressler T., Poulsen H.E., Hoiby N. Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob. Agents Chemother. 2005, 49:2276-2282.
5. Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial Disk and Dilution Susceptibility Test for Bacteria Isolated from Animals: Approved Standard - Third Edition. CLSI Document M31-A3 2008, CLSI, Wayne, PA, USA.
6. Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial Susceptibility Testing: Twenty-first Informational Supplement. CLSI Document M100-S21 2011, CLSI, Wayne, PA, USA.
7. Cox E.C., Gibson T.C. Selection for high mutation rates in chemostats. Genetics 1974, 77:169-184.
8. Ferroni A., Guillemot D., Moumile K., Bernede C., Le Bourgeois M., Waernessyckle S., Descamps P., Sermet-Gaudelus I., Lenoir G., Berche P., Taddei F. Effect of mutator P. aeruginosa on antibiotic resistance acquisition and respiratory function in cystic fibrosis. Pediatr. Pulmonol. 2009, 44:820-825.
9. Giraud A., Matic I., Radman M., Fons M., Taddei F. Mutator bacteria as a risk factor in treatment of infectious diseases. Antimicrob. Agents Chemother. 2002, 46:863-865.
10. Giraud A., Matic I., Tenaillon O., Clara A., Radman M., Fons M., Taddei F. Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut. Science 2001, 291:2606-2608.
11. Gutierrez O., Juan C., Perez J.L., Oliver A. Lack of association between hypermutation and antibiotic resistance development in Pseudomonas aeruginosa isolates from intensive care unit patients. Antimicrob. Agents Chemother. 2004, 48:3573-3575.
12. Hall L.M., Henderson-Begg S.K. Hypermutable bacteria isolated from humans - a critical analysis. Microbiology 2006, 152:2505-2514.
13. Lange C., Cardoso M., Senczek D., Schwarz S. Molecular subtyping of Staphylococcus aureus isolates from cases of bovine mastitis in Brazil. Vet. Microbiol. 1999, 67:127-141.
14. Macia M.D., Blanquer D., Togores B., Sauleda J., Perez J.L., Oliver A. Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections. Antimicrob. Agents Chemother. 2005, 49:3382-3386.
15. Mao E.F., Lane L., Lee J., Miller J.H. Proliferation of mutators in A cell population. J. Bacteriol. 1997, 179:417-422.
16. Martinez-Solano L., Macia M.D., Fajardo A., Oliver A., Martinez J.L. Chronic Pseudomonas aeruginosa infection in chronic obstructive pulmonary disease. Clin. Infect. Dis. 2008, 47:1526-1533.
17. Matic I., Rayssiguier C., Radman M. Interspecies gene exchange in bacteria: the role of SOS and mismatch repair systems in evolution of species. Cell 1995, 80:507-515.
18. O'Neill A.J., Chopra I. Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low. J. Antimicrob. Chemother. 2002, 50:161-169.
19. O'Neill A.J., Chopra I. Lack of evidence for involvement of hypermutability in emergence of vancomycin-intermediate Staphylococcus aureus. Antimicrob. Agents Chemother. 2003, 47:1484-1485.
20. Oliver A., Baquero F., Blazquez J. The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants. Mol. Microbiol. 2002, 43:1641-1650.
21. Oliver A., Canton R., Campo P., Baquero F., Blazquez J. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science 2000, 288:1251-1254.
22. Prunier A.L., Leclercq R. Role of mutS and mutL genes in hypermutability and recombination in Staphylococcus aureus. J. Bacteriol. 2005, 187:3455-3464.
23. Prunier A.L., Malbruny B., Laurans M., Brouard J., Duhamel J.F., Leclercq R. High rate of macrolide resistance in Staphylococcus aureus strains from patients with cystic fibrosis reveals high proportions of hypermutable strains. J. Infect. Dis. 2003, 187:1709-1716.
24. Sniegowski P.D., Gerrish P.J., Johnson T., Shaver A. The evolution of mutation rates: separating causes from consequences. Bioessays 2000, 22:1057-1066.
25. Sniegowski P.D., Gerrish P.J., Lenski R.E. Evolution of high mutation rates in experimental populations of E. coli. Nature 1997, 387:703-705.
26. Taddei F., Radman M., Maynard-Smith J., Toupance B., Gouyon P.H., Godelle B. Role of mutator alleles in adaptive evolution. Nature 1997, 387:700-702.
27. Watson M.E., Burns J.L., Smith A.L. Hypermutable Haemophilus influenzae with mutations in mutS are found in cystic fibrosis sputum. Microbiology 2004, 150:2947-2958.