Glycerol and acetaminophen as adjuvant therapy did not affect the outcome of bacterial meningitis in malawian children

Pediatric Infectious Disease Journal

Volumn 33, Issue 2, 2014, Pages 214-216

  Molyneux, Elizabeth M ^a   Kawaza, Kondwani ^a   Phiri, Ajib ^a   Chimalizeni, Yamikani ^a   Mankhambo, Limangeni ^a   Schwalbe, Edward ^b   Kataja, Matti ^c   Pensulo, Paul ^a   Chilton, Lucy ^b   Peltola, Heikki ^d  

^a UNIVERSITY OF MALAWI   (Malawi)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI AND HELSINKI UNIVERSITY HOSPITAL   (Finland)

Author keywords

adjuvant glycerol in meningitis

Indexed keywords

CEFTRIAXONE; CIPROFLOXACIN; GLYCEROL; PARACETAMOL; PLACEBO;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ANEMIA; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL MENINGITIS; BILATERAL HEARING LOSS; CHILDHOOD DISEASE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HOSPITALIZED CHILD; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INFANT DISEASE; INFANT MORTALITY; MAJOR CLINICAL STUDY; MALAWI; PNEUMOCOCCAL MENINGITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ACETAMINOPHEN; ANTI-BACTERIAL AGENTS; CEFTRIAXONE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; GLYCEROL; HEARING LOSS; HUMANS; INFANT; MALAWI; MENINGITIS, BACTERIAL; TREATMENT OUTCOME;

EID: 84892994397     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000000122     Document Type: Article

References (9)

1. Molyneux EM, Walsh AL, Forsyth H, et al. Dexamethasone treatment in childhood bacterial meningitis in Malawi a randomised controlled trial. Lancet. 2002;360211-218
2. Scarborough M, Gordon SB, Whitty CJ, et al. Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. N Engl J Med. 2007;3572441-2450
3. Peltola H, Roine I, Fernández J, et al. Adjuvant glycerol andor dexamethasone to improve the outcomes of childhood bacterial meningitis a prospective, randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2007;451277-1286
4. Kuikka A. Factors associated with the outcome of bacteraemia during twenty years (1976-1996) with special reference to bacteraemias due to Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Academic dissertation, University of Helsinki, Helsinki 199983
5. Ajdukiewicz KM, Cartwright KE, Scarborough M, et al. Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi a double-blind, randomised controlled trial. Lancet Infect Dis. 2011;11293-300
6. Wall ECB, Ajdukeiwics KMB, Heyderman R et al. Osmotic therapies added to antibiotics for acute bacterial meningitis. Cochrane review. Cochrane Database Syst Rev. 2013;3CD008806
7. Daza P, Banda R, Misoya K, et al. The impact of routine infant immunization with Haemophilus influenzae type b conjugate vaccine in Malawi, a country with high human immunodeficiency virus prevalence. Vaccine. 2006;246232-6239
8. McCormick DW, Molyneux EM. Bacterial meningitis and Haemophilus influenzae type b conjugate vaccine, Malawi. Emerg Infect Dis. 2011;17688-690
9. Everett DB, Mukaka M, Denis B, et al. Ten years of surveillance for invasive Streptococcus pneumoniae during the era of antiretroviral scale-up and cotrimoxazole prophylaxis in Malawi. PLoS One. 2011;6e17765