Evaluation of non-conventional polar modifiers on immobilized chiral stationary phases for improved resolution of enantiomers by supercritical fluid chromatography

Journal of Chromatography A

Volumn 1328, Issue , 2014, Pages 98-103

  DaSilva, Jimmy O ^a   Coes, Brandyce ^a   Frey, Lisa ^a   Mergelsberg, Ingrid ^a   McClain, Ray ^a   Nogle, Lisa ^a   Welch, Christopher J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Analytical; Chiral; Chromatography; Columns; Preparative; SFC

Indexed keywords

ANALYTICAL; CHIRAL; CHROMATOGRAPHIC PERFORMANCE; CHROMATOGRAPHIC SEPARATIONS; PREPARATIVE; RESOLUTION OF ENANTIOMERS; SFC; SUPER CRITICAL FLUID CHROMATOGRAPHY;

ACETONE; CARBON DIOXIDE; CHROMATOGRAPHY; COLUMNS (STRUCTURAL); DICHLOROMETHANE; EFFLUENT TREATMENT; ETHANOL; GAS CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; SUPERCRITICAL FLUIDS;

ORGANIC SOLVENTS;

2 METHYL TETRAHYDROFURAN; ACETIC ACID ETHYL ESTER; ACETONE; CHLOROFORM; CYCLOPENTYL METHYL ETHER; DICHLOROMETHANE; DIMETHYL ETHER; N,N DIMETHYLFORMAMIDE; TERT BUTYL METHYL ETHER; TETRAHYDROFURAN; TOLUENE; TRIFLUOROETHANOL; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; ENANTIOMER; FLOW RATE; PHASE SEPARATION; PRIORITY JOURNAL; RACEMIZATION; SEPARATION TECHNIQUE; SOLUBILITY; SUPERCRITICAL FLUID CHROMATOGRAPHY; VISCOSITY;

ANALYTICAL; CHIRAL; CHROMATOGRAPHY; COLUMNS; PREPARATIVE; SFC;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, SUPERCRITICAL FLUID; PHARMACEUTICAL PREPARATIONS; SOLVENTS; STEREOISOMERISM;

EID: 84892975533     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.12.073     Document Type: Article

References (23)

1. Núñez M.C., Garcia-Rubiño M.E., Conejo-García A., Cruz-López O., Kimatrai M., Gallo M.A., Espinosa A., Campos J.M. Curr. Med. Chem. 2009, 16:2064.
2. Da Silva J.O., Yip H.S., Hegde V. Am. Pharm. Rev. 2009, 12:98.
3. Welch C.J., Leonard W., DaSilva J.O., Biba M., Albaneze-Walker J., Henderson D.W., Laing B., Mathre D.J. LC-GC N. Am. 2005, 23:16.
4. Miller L. J. Chromatogr. A 2012, 1250:250.
5. Welch C.J., Fairchild J., Sajonz P. Chirality 2007, 19:607.
6. Francotte E., Huynh D. J. Pharm. Biomed. Anal. 2002, 27:421.
7. Thunberg J., Hashemi J., Andersson S. J. Chromatogr. B 2008, 875:72.
8. Ikai T., Yamamoto C., Kamigaito M., Okamoto Y. J. Chromatogr. A 2007, 1157:151.
9. http://www.chiraltech.com/immobilized-polysaccharide-CSPs.asp.
10. Zhang T., Franco P., Nguyen D., Hamasaki R., Miyamoto S., Ohnishi A., Murakami T. J. Chromatogr. A 2012, 1269:178.
11. Zhang T., Nguyen D., Franco P. J. Chromatogr. A 2008, 1191:214.
12. Franco P., Zhang T. J. Chromatogr. B 2008, 875:48.
13. Miller L. J. Chromatogr. A 2012, 1256:261.
14. Byrne N., Hayes-Larson E., Liao W., Kraml C.M. J. Chromatogr. B 2008, 875:237.
15. Pirkle W.H., Welch C.J. J. Liq. Chromatogr. 1991, 14:1.
16. Pirzada Z., Personick M., Biba M., Gong X., Zhou L., Schafer W., Roussel C., Welch C.J. J. Chromatogr. A 2010, 1217:1134.
17. Cantrell G.O., Stringham R.W., Blackwell J.A. Anal. Chem. 1996, 68:3645.
18. Capello C., Fischer U., Hungerbühler K. Green Chem. 2007, 9:927.
19. Antonucci V., Coleman J., Ferry J.B., Johnson N., Mathe M., Scott J.P., Xu J. Org. Proc. Res. Dev. 2011, 15:939.
20. http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Brochure/greener_solvent_alternatives.Par.0001.File.tmp/greener_solvent_alternatives.pdf.
21. Sadek P.C. The HPLC Solvent Guide 1996, Wiley-Interscience, New York City, (Chapter 1).
22. Kraml C. Am. Pharm. Rev. 2008, 11:80.
23. Welch C.J., Wu N., Biba M., Hartman R., Brkovic T., Gong X., Helmy R., Schafer W., Cuff J., Pirzada Z. Trends Anal. Chem. 2010, 29:667.