TTF-1 and Napsin-A are expressed in a subset of cholangiocarcinomas arising from the gallbladder and hepatic ducts: Continued caveats for utilization of immunohistochemistry panels

American Journal of Surgical Pathology

Volumn 38, Issue 2, 2014, Pages 224-227

  Surrey, Lea F ^a   Frank, Renee ^b   Zhang, Paul J ^b   Furth, Emma E ^b  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

cholangiocarcinoma; immunohistochemistry; Napsin A; TTF 1

Indexed keywords

ASPARTIC PROTEINASE; NAPSA PROTEIN, HUMAN; NUCLEAR PROTEIN; PARAFFIN; THYROID NUCLEAR FACTOR 1; TRANSCRIPTION FACTOR; TUMOR MARKER;

ARTICLE; BILE DUCT CARCINOMA; BILE DUCT TUMOR; BIOPSY; CASE CONTROL STUDY; DIFFERENTIAL DIAGNOSIS; ENZYMOLOGY; FEMALE; GALLBLADDER TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC BILE DUCT; MALE; MIDDLE AGED; PATHOLOGY; PHENOTYPE; PREDICTIVE VALUE; PROGNOSIS;

ASPARTIC ACID ENDOPEPTIDASES; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; BIOPSY; CASE-CONTROL STUDIES; CHOLANGIOCARCINOMA; DIAGNOSIS, DIFFERENTIAL; FEMALE; GALLBLADDER NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PARAFFIN EMBEDDING; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84892971258     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000138     Document Type: Article

References (11)

1. Lau SK, Luthringer DJ, Eisen RN. Thyroid transcription factor-1: a review. Appl Immunohistochem Mol Morphol. 2002;10:97-102.
2. Kadivar M, Boozari B. Applications and limitations of immuno-histochemical expression of "napsin-A" in distinguishing lung adenocarcinoma from adenocarcinomas of other organs. Appl Immunohistochem Mol Morphol. 2012;21:191-195.
3. Wilbertz T, Maier S, Perner S. NKX2-1 (NK2 homeobox 1). Atlas Genet Cytogenet Oncol Haematol. 2010. Available at: http://AtlasGeneticsOncology.org/ Genes/NKX2-1ID44015ch14q13.html. Accessed May 23, 2013.
4. Pegolo E, Machin P, Damante G, et al. TTF-1 positivity in 2 cases of adenocarcinoma of the gastrointestinal tract. Appl Immuno-histochem Mol Morphol. 2012. [Epub ahead of print].
5. Ordonez NG. Value of thyroid transcription factor-1 immunostain-ing in tumor diagnosis: a review and update. Appl Immunohistochem Mol Morphol. 2012;20:429-444.
6. Zhang PJ, Gao HG, Pasha TL, et al. TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems. Int J Gynecol Pathol. 2009;28:10-18.
7. Turner BM, Cagle PT, Sainz IM, et al. Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray. Arch Pathol Lab Med. 2012;136:163-171.
8. Mukhopadhyay S, Katzenstein AL. Comparison of monoclonal napsin A, polyclonal napsin A, and TTF-1 for determining lung origin in metastatic adenocarcinomas. Am J Clin Pathol. 2012;138: 703-711.
9. Pang Y, von Turkovich M, Wu H, et al. The binding of thyroid transcription factor-1 and hepatocyte paraffin 1 to mitochondrial proteins in hepatocytes: a molecular and immunoelectron microscopic study. Am J Clin Pathol. 2006;125:722-726.
10. Gu K, Shah V, Ma C, et al. Cytoplasmic immunoreactivity of thyroid transcription factor-1 (clone 8G7G3/1) in hepatocytes: true positivity or cross-reaction? Am J Clin Pathol. 2007;128: 382-388.
11. Lei JY, Bourne PA, diSant'Agnese PA, et al. Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma vs cholangiocarcinoma and metastatic carcinoma of the liver. Am J Clin Pathol. 2006;125:519-525.