Tale proteins bind to both active and inactive chromatin

Biochemical Journal

Volumn 458, Issue 1, 2014, Pages 153-158

  Scott, James N F ^a   Kupinski, Adam P ^a   Kirkham, Christopher M ^a   Tuma, Roman ^a   Boyes, Joan M ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Chromatin; Genome engineering; Nucleosome; Transcription; Transcription activator like effector proteins (tale proteins)

Indexed keywords

TRANSCRIPTION ACTIVATOR LIKE EFFECTOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHROMATIN; CHROMATIN STRUCTURE; DNA SEQUENCE; GENE CONTROL; GENE LOCUS; HISTONE ACETYLATION; HISTONE MODIFICATION; IN VITRO STUDY; IN VIVO STUDY; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN BINDING;

ACETYLATION; ANIMALS; BINDING SITES; CHROMATIN; MICE; NIH 3T3 CELLS; PROTEIN BINDING; TRANS-ACTIVATORS;

EID: 84892924161     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131327     Document Type: Article

References (25)

1. Workman, J. L. and Buchman, A. R. (1993) Multiple functions of nucleosomes and regulatory factors in transcription. Trends Biochem Sci. 18, 90-95
2. Taylor, I. C., Workman, J. L., Schuetz, T. J. and Kingston, R. E. (1991) Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains. Genes Dev. 5, 285-298
3. Li, B., Adams, C. C. and Workman, J. L. (1994) Nucleosome binding by the constitutive transcription factor Sp1. J. Biol. Chem. 269, 7756-7763
4. Perlmann, T. and Wrange, O. (1988) Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome. EMBO J. 7, 3073-3079
5. Pina, B., Bruggemeier, U. and Beato, M. (1990) Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter. Cell 60, 719-731
6. Widom, J. (1998) Structure, dynamics, and function of chromatin in vitro. Annu. Rev. Biophys. Biomol. Struct. 27, 285-327
7. Adams, C. C. and Workman, J. L. (1995) Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative. Mol. Cell. Biol. 15, 1405-1421
8. Tolhuis, B., Palstra, R. J., Splinter, E., Grosveld, F. and de Laat, W. (2002) Looping and interaction between hypersensitive sites in the active β-globin locus. Mol. Cell 10, 1453-1465
9. Zhang, F., Cong, L., Lodato, S., Kosuri, S., Church, G. M. and Arlotta, P. (2011) Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat. Biotechnol. 29, 149-153
10. Cong, L., Zhou, R., Kuo, Y. C., Cunniff, M. and Zhang, F. (2012) Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat. Commun. 3, 968
11. Miller, J. C., Tan, S., Qiao, G., Barlow, K. A., Wang, J., Xia, D. F., Meng, X., Paschon, D. E., Leung, E., Hinkley, S. J. et al. (2011) A TALE nuclease architecture for efficient genome editing. Nat. Biotechnol. 29, 143-148
12. Bultmann, S., Morbitzer, R., Schmidt, C. S., Thanisch, K., Spada, F., Elsaesser, J., Lahaye, T and Leonhardt, H. (2012) Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Res. 40, 5368-5377
13. Sanjana, N. E., Cong, L., Zhou, Y., Cunniff, M. M., Feng, G. and Zhang, F. (2012) A transcription activator-like effector toolbox for genome engineering. Nat. Protoc. 7, 171-192
14. Hockemeyer, D., Wang, H., Kiani, S., Lai, C. S., Gao, Q., Cassady, J. P., Cost, G. J., Zhang, L., Santiago, Y., Miller, J. C. et al. (2011) Genetic engineering of human pluripotent cells using TALE nucleases. Nat. Biotechnol. 29, 731-734
15. Luger, K., Rechsteiner, T. J., Flaus, A. J., Waye, M. M. and Richmond, T. J. (1997) Characterization of nucleosome core particles containing histone proteins made in bacteria. J. Mol. Biol. 272, 301-311
16. Baumann, M., Mamais, A., McBlane, F., Xiao, H. and Boyes, J. (2003) Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences. EMBO J. 22, 5197-5207
17. Boyd, K. E. and Farnham, P. J. (1999) Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol. Cell. Biol. 19, 8393-8399
18. Kumar, V. and Chambon, P. (1988) The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55, 145-156
19. Boyes, J. and Felsenfeld, G. (1996) Tissue-specific factors additively increase the probability of the all- or-none formation of a hypersensitive site. EMBO J. 15, 2496-2507
20. Grange, S. and Boyes, J. (2007) Chromatin opening is tightly linked to enhancer activation at the κ light chain locus. Biochem. Biophys. Res. Commun. 363, 223-228
21. Chen, Y. Y., Wang, L. C., Huang, M. S. and Rosenberg, N. (1994) An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes Dev. 8, 688-697
22. Xu, C. R. and Feeney, A. J. (2009) The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. J. Immunol. 182, 1362-1369
23. Perez-Pinera, P., Ousterout, D. G., Brunger, J. M., Farin, A. M., Glass, K. A., Guilak, F., Crawford, G. E., Hartemink, A. J. and Gersbach, C. A. (2013) Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat. Methods 10, 239-342
24. Maeder, M. L., Linder, S. J., Reyon, D., Angstman, J. F., Fu, Y., Sander, J. D. and Joung, J. K. (2013) Robust, synergistic regulation of human gene expression using TALE activators. Nat. Methods 10, 243-245
25. Bevington, S. and Boyes, J. (2013) Transcription-coupled eviction of histones H2A/H2B governs V(D)J recombination. EMBO J. 32, 1381-1392