Imaging benign hepatocellular tumors: Atypical forms and diagnostic traps

Diagnostic and Interventional Imaging

Volumn 94, Issue 7-8, 2013, Pages 677-695

  Baranes, L ^a,b   Chiaradia, M ^a,b   Pigneur, F ^a   Decaens, T ^a,b   Djabbari, M ^a   Zegai B ^a   Costentin, C ^a   Laurent, A ^a   Calderaro, J ^a   Rahmouni, A ^a,b   Luciani, A ^a,b,c  

^a HENRI MONDOR HOSPITAL   (France)

^b FACULTÉ DE MÉDECINE   (France)

^c INSERM U955   (France)

Author keywords

Adenoma; Benign tumor; Focal nodular hyperplasia; Liver

Indexed keywords

ECHO CONTRAST MEDIUM;

ARTICLE; ECHOGRAPHY; HUMAN; LIVER ADENOMA; LIVER CELL; LIVER TUMOR; NODULAR HYPERPLASIA; NON INVASIVE PROCEDURE; NUCLEAR MAGNETIC RESONANCE IMAGING; SCAR; TUMOR CLASSIFICATION;

ADENOMA; BENIGN TUMOR; FOCAL NODULAR HYPERPLASIA; LIVER;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; DIAGNOSTIC IMAGING; FEMALE; HUMANS; LIVER DISEASES; LIVER NEOPLASMS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84892896426     PISSN: None     EISSN: 22115684     Source Type: Journal    
DOI: 10.1016/j.diii.2013.05.002     Document Type: Short Survey

References (36)

1. Cherqui D, Rahmouni A, Charlotte F, Boulahdour H, Metreau JM, Meignan M, et al. Management of focal nodular hyperplasia and hepatocellular adenoma in young women: A series of 41 patients with clinical, radiological, and pathological correlations. Hepatology 1995;22(6):1674-81
2. Belghiti J, Pateron D, Panis Y, Vilgrain V, Flejou JF, Benhamou JP, et al. Resection of presumed benign liver tumours. Br J Surg 1993;80(3):380-3
3. Dokmak S, Paradis V, Vilgrain V, Sauvanet A, Farges O, Valla D, et al. A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas. Gastroenterology 2009;137(5):1698-705
4. Rebouissou S, Bioulac-Sage P, Zucman-Rossi J. Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma. J Hepatol 2008;48(1):163-70
5. Bioulac-Sage P, Rebouissou S, Thomas C, Blanc JF, Saric J, Sa Cunha A, et al. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 2007;46(3):740-8
6. Mortele KJ, Praet M, Van Vlierberghe H, Kunnen M, Ros PR. CT and MR imaging findings in focal nodular hyperplasia of the liver: Radiologic- pathologic correlation. AJR Am J Roentgenol 2000;175(3):687-92
7. Grazioli L, Morana G, Kirchin MA, Schneider G. Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: Prospective study. Radiology 2005;236(1):166-77
8. Laumonier H, Bioulac-Sage P, Laurent C, Zucman-Rossi J, Balabaud C, Trillaud H. Hepatocellular adenomas: Magnetic resonance imaging features as a function of molecular pathological classification. Hepatology 2008;48(3):808-18
9. Mattison GR, Glazer GM, Quint LE, Francis IR, Bree RL, Ensminger WD. MR imaging of hepatic focal nodular hyperplasia: Characterization and distinction from primary malignant hepatic tumors. AJR Am J Roentgenol 1987;148(4):711-5
10. Mathieu D, Rahmouni A, Anglade MC, Falise B, Beges C, Gheung P, et al. Focal nodular hyperplasia of the liver: Assessment with contrast enhanced TurboFLASH MR imaging. Radiology 1991;180(1):25-30
11. Vilgrain V, Flejou JF, Arrive L, Belghiti J, Najmark D, Menu Y, et al. Focal nodular hyperplasia of the liver: MR imaging and pathologic correlation in 37 patients. Radiology 1992;184(3):699-703
12. Hamm B, Staks T, Muhler A, Bollow M, Taupitz M, Frenzel T, et al. Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: Safety, pharmacokinetics, and MR imaging. Radiology 1995;195(3):785-92
13. Morana G, Grazioli L, Kirchin MA, Bondioni MP, Faccioli N, Guarise A, et al. Solid hypervascular liver lesions: Accurate identification of true benign lesions on enhanced dynamic and hepatobiliary phase magnetic resonance imaging after gadobenate dimeglumine administration. Invest Radiol 2011;46(4):225-39
14. Grazioli L, Bondioni MP, Haradome H, Motosugi U, Tinti R, Frittoli B, et al. Hepatocellular adenoma and focal nodular hyperplasia: Value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology 2012;262(2):520-9
15. Purysko AS, Remer EM, Coppa CP, Obuchowski NA, Schneider E, Veniero JC. Characteristics and distinguishing features of hepatocellular adenoma and focal nodular hyperplasia on gadoxetate disodium-enhanced MRI. AJR Am J Roentgenol 2012;198(1):115-23
16. Dietrich CF. Characterisation of focal liver lesions with contrast enhanced ultrasonography. Eur J Radiol 2004;51:S9-17
17. Kim MJ, Lim HK, Kim SH, Choi D, Lee WJ, Lee SJ, et al. Evaluation of hepatic focal nodular hyperplasia with contrast enhanced gray scale harmonic sonography: Initial experience. J Ultrasound Med 2004;23(2):297-305
18. Tranquart F, Correas JM, Ladam Marcus V, Manzoni P, Vilgrain V, Aube C, et al. Real time contrast enhanced ultrasound in the evaluation of focal liver lesions: Diagnostic efficacy and economical issues from a French multicentric study. J Radiol 2009;90(1 Pt 2):109-22
19. Trillaud H, Bruel JM, Valette PJ, Vilgrain V, Schmutz G, Oyen R, et al. Characterization of focal liver lesions with SonoVue-enhanced sonography: International multicenterstudy in comparison to CT and MRI. World J Gastroenterol 2009;15(30):3748-56
20. Zucman-Rossi J, Jeannot E, Nhieu JT, Scoazec JY, Guettier C, Rebouissou S, et al. Genotype-phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC. Hepatology 2006;43(3):515-24
21. Bioulac-Sage P, Laumonier H, Couchy G, Le Bail B, Sa Cunha A, Rullier A, et al. Hepatocellular adenoma management and phenotypic classification: The Bordeaux experience. Hepatology 2009;50(2):481-9
22. Kim TK, Jang HJ, Burns PN, Murphy-Lavallee J, Wilson SR. Focal nodular hyperplasia and hepatic adenoma: Differentiation with low-mechanical-index contrast enhanced sonography. AJR Am J Roentgenol 2008;190(1):58-66
23. Laumonier H, Cailliez H, Balabaud C, Possenti L, Zucman-Rossi J, Bioulac-Sage P, et al. Role of contrast-enhanced sonography in differentiation of subtypes of hepatocellular adenoma: Correlation with MRI findings. AJR Am J Roentgenol 2012;199(2):341-18
24. Nguyen BN, Flejou JF, Terris B, Belghiti J, Degott C. Focal nodular hyperplasia of the liver: A comprehensive pathologic study of 305 lesions and recognition of new histologic forms. Am J Surg Pathol 1999;23(12):1441-54
25. Luciani A, Kobeiter H, Maison P, Cherqui D, Zafrani ES, Dhumeaux D, et al. Focal nodular hyperplasia of the liver in men: Is presentation the same in men and women? Gut 2002;50(6):877-80
26. Siegelman ES, Outwater EK, Furth EE, Rubin R. MR imaging of hepatic nodular regenerative hyperplasia. J Magn Reson Imaging 1995;5(6):730-2
27. Brancatelli G, Federle MP, Grazioli L, Golfieri R, Lencioni R. Benign regenerative nodules in Budd -Chiari syndrome and other vascular disorders of the liver: Radiologic-pathologic and clinical correlation. Radiographics 2002;22(4):847-62
28. Valls C, Iannacconne R, Alba E, Murakami T, Hori M, Passariello R, et al. Fat in the liver: Diagnosis and characterization. Eur Radiol 2006;16(10):2292-308
29. Ferlicot S, Kobeiter H, Tran Van Nhieu J, Cherqui D, Dhumeaux D, Mathieu D, et al. MRI of atypical focal nodular hyperplasia of the liver: Radiology-pathology correlation. AJR Am J Roentgenol 2004;182(5):1227-31
30. Mortele KJ, Stubbe J, Praet M, Van Langenhove P, De Bock G, Kunnen M. Intratumoral steatosis in focal nodular hyperplasia coinciding with diffuse hepatic steatosis: CT and MRI findings with histologic correlation. Abdom Imaging 2000;25(2):179-81
31. Yen YH, Wang JH, Lu SN, Chen TY, Changchien CS, Chen CH, et al. Contrast enhanced ultrasonographic spoke-wheel sign in hepatic focal nodular hyperplasia. Eur J Radiol 2006;60(3):439-44
32. Fujiwara H, Sekine S, Onaya H, Shimada K, Mikata R, Arai Y. Ring-like enhancement of focal nodular hyperplasia with hepatobiliary phase Gd-EOB-DTPA-enhanced magnetic resonance imaging: Radiological-pathological correlation. Jpn J Radiol 2011;29(10):739-43
33. Choi JY, Kim MJ, Park YN, Lee JM, Yoo SK, Rha SY, et al. Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: Correlation with histological characteristics. AJR Am J Roentgenol 2011;197(2):399-405
34. Lee MH, Kim SH, Park MJ, Park CK, Rhim H. Gadoxetic acidenhanced hepatobiliary phase MRI and high-b-value diffusionweighted imaging to distinguish well-differentiated hepatocellular carcinomas from benign nodules in patients with chronic liver disease. AJR Am J Roentgenol 2011;197(5):W868-75
35. Kitao A, Zen Y, Matsui O, Gabata T, Kobayashi S, Koda W, et al. Hepatocellular carcinoma: Signal intensity at gadoxetic acidenhanced MR Imaging: Correlation with molecular transporters and histopathologic features. Radiology 2010;256(3):817-26
36. Ronot M, Bahrami S, Calderaro J, Valla DC, Bedossa P, Belghiti J, et al. Hepatocellular adenomas: Accuracy of magnetic resonance imaging and liver biopsy in subtype classification. Hepatology 2011;53(4):1182-91