Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction.

Journal of the American Heart Association

Volumn 2, Issue 4, 2013, Pages

  Rayner, Benjamin S ^a   Figtree, Gemma A ^b   Sabaretnam, Tharani ^b   Shang, Ping ^b   Mazhar, Jawad ^b   Weaver, James C ^b   Lay, William N ^b   Witting, Paul K ^b   Hunyor, Stephen N ^b   Grieve, Stuart M ^b   Khachigian, Levon M ^b   Bhindi, Ravinay ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; DEOXYRIBOZYME; EARLY GROWTH RESPONSE FACTOR 1; MESSENGER RNA; OLIGONUCLEOTIDE;

ANIMAL; APOPTOSIS; DISEASE MODEL; DOWN REGULATION; ECHOCARDIOGRAPHY; ENZYMOLOGY; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART STROKE VOLUME; MALE; METABOLISM; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NEUTROPHIL CHEMOTAXIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PREVENTION AND CONTROL; SWINE; SYSTOLE; TIME;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; DNA, CATALYTIC; DOWN-REGULATION; EARLY GROWTH RESPONSE PROTEIN 1; ECHOCARDIOGRAPHY; INFLAMMATION MEDIATORS; MAGNETIC RESONANCE IMAGING, CINE; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NEUTROPHIL INFILTRATION; OLIGONUCLEOTIDES; OXIDATIVE STRESS; RNA, MESSENGER; STROKE VOLUME; SWINE; SYSTOLE; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84892882486     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000023     Document Type: Article

References (0)