Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 3, 2014, Pages 1070-1076

  Mizushina, Yoshiyuki ^a   Suzuki Fukudome, Hiroe ^b   Takeuchi, Toshifumi ^b   Takemoto, Kenji ^b   Kuriyama, Isoko ^a   Yoshida, Hiromi ^a   Kamisuki, Shinji ^b   Sugawara, Fumio ^b  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Computer simulation; DNA polymerase ; Enzyme inhibitor; Formosusin A

Indexed keywords

ALKENE; DNA DIRECTED DNA POLYMERASE BETA; ENZYME INHIBITOR; FORMOSUSIN A; NATURAL PRODUCT; PECILOCIN; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DNA TEMPLATE; DRUG DETERMINATION; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; FUNGUS CULTURE; HUMAN; HUMAN VERSUS NONHUMAN DATA; IC 50; IN VITRO STUDY; NONHUMAN; PAECILOMYCES; PAECILOMYCES FORMOSUS; SPECTROSCOPY;

FUNGI; HEXAPODA; MAMMALIA; PROKARYOTA; RATTUS;

COMPUTER SIMULATION; DNA POLYMERASE Β; ENZYME INHIBITOR; FORMOSUSIN A;

ANIMALS; DNA POLYMERASE BETA; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; FATTY ALCOHOLS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MAMMALS; MOLECULAR STRUCTURE; PAECILOMYCES; PYRROLIDINONES; RATS;

EID: 84892815747     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.038     Document Type: Article

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