Initial experience using aminophylline to improve renal dysfunction in the pediatric cardiovascular ICU

Pediatric Critical Care Medicine

Volumn 15, Issue 1, 2014, Pages 21-27

  Axelrod, David M ^a   Anglemyer, Andrew T ^b   Sherman Levine, Sara F ^a   Zhu, Aihua ^a   Grimm, Paul C ^a   Roth, Stephen J ^a   Sutherland, Scott M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute kidney injury; Aminophylline; Congenital heart defect; Intensive care; Ischemia reperfusion injury; Oliguria

Indexed keywords

AMINOPHYLLINE; AMIODARONE; BUMETANIDE; CREATININE; FUROSEMIDE; HYDROCHLOROTHIAZIDE; METOLAZONE; THEOPHYLLINE;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; ARTIFICIAL VENTILATION; ASSISTED CIRCULATION; CARDIOMYOPATHY; CEREBROVASCULAR ACCIDENT; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONGENITAL HEART DISEASE; CONGESTIVE CARDIOMYOPATHY; CONSULTATION; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG CONCENTRATION; EXTRACORPOREAL OXYGENATION; FEMALE; FLUID INTAKE; GLOMERULUS FILTRATION RATE; HEART FAILURE; HEART VENTRICLE TACHYCARDIA; HORSESHOE KIDNEY; HOSPITAL ADMISSION; HUMAN; HYPERVOLEMIA; INSOMNIA; INTENSIVE CARE; IRRITABILITY; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; LENGTH OF STAY; MALE; MOOD DISORDER; MORTALITY; MULTICYSTIC DYSPLASTIC KIDNEY; NAUSEA; NEPHRECTOMY; OLIGURIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SOLITARY KIDNEY; THEOPHYLLINE BLOOD LEVEL; URINE VOLUME; VOMITING;

ACUTE KIDNEY INJURY; AMINOPHYLLINE; CHILD; CHILD, PRESCHOOL; CREATININE; DIURETICS; FEMALE; FUROSEMIDE; GLOMERULAR FILTRATION RATE; HEART DISEASES; HUMANS; HYDROCHLOROTHIAZIDE; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, PEDIATRIC; MALE; OLIGURIA; PHOSPHODIESTERASE INHIBITORS; RETROSPECTIVE STUDIES;

EID: 84892732683     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/01.pcc.0000436473.12082.2f     Document Type: Article

References (40)

1. Lafrance JP, Miller DR: Acute kidney injury associates with increased long-term mortality. J Am Soc Nephrol 2010; 21:345-352
2. Zappitelli M, Bernier PL, Saczkowski R.S., et al.: A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery. Kidney Int 2009; 76:885-892
3. Bellomo R, Uchino S, Naka T., et al.: Hidden evidence to the West: Multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals. Intensive Care Med 2004; 30:911-917
4. Dent CL, Ma Q, Dastrala S., et al.: Plasma neutrophil gelatinase-asso-ciated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: A prospective uncontrolled cohort study. Crit Care 2007; 11:R127
5. Baskin E, Saygili A, Harmanci K., et al.: Acute renal failure and mortality after open-heart surgery in infants. Ren Fail 2005; 27:557-560
6. Bennett M, Dent CL, Ma Q, et al.: Urine NGAL predicts severity of acute kidney injury after cardiac surgery: A prospective study. Clin J Am Soc Nephrol 2008; 3:665-673
7. Akcan-Arikan A., Zappitelli M, Loftis L.L., et al.: Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 2007; 71:1028-1035
8. Blinder JJ, Goldstein SL, Lee V.V., et al.: Congenital heart surgery in infants: Effects of acute kidney injury on outcomes. J Thorac Cardiovasc Surg 2012; 143:368-374
9. Li S, Krawczeski CD, Zappitelli M, et al.; TRIBE-AKI Consortium: Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study. Crit Care Med 2011; 39:1493-1499
10. Arikan AA, Zappitelli M, Goldstein S.L., et al.: Fluid overload is associated with impaired oxygenation and morbidity in critically ill children. Pediatr Crit Care Med 2012; 13:253-258
11. Sutherland SM, Zappitelli M, Alexander S.R., et al.: Fluid overload and mortality in children receiving continuous renal replacement therapy: The prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis 2010; 55:316-325
12. Flori HR, Church G, Liu K.D., et al.: Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Crit Care Res Pract 2011; 2011:854142
13. Nigwekar SU, Waikar SS: Diuretics in acute kidney injury. Semin Nephrol 2011; 31:523-534
14. Lassnigg A, Donner E, Grubhofer G., et al.: Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. J Am Soc Nephrol 2000; 11:97-104
15. Mishra J, Dent C, Tarabishi R., et al.: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365:1231-1238
16. Press NJ, Gessi S, Borea P.A., et al.: Therapeutic potential of adenosine receptor antagonists and agonists. Expert Opin Ther Pat 2007; 17:979-991
17. Dragunow M: Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. Pharmacol Biochem Behav 1990; 36:751-755
18. Osswald H, Gleiter C, Mühlbauer B: Therapeutic use of theophylline to antagonize renal effects of adenosine. Clin Nephrol 1995; 43(SUPPL. 1):S33-S37
19. Thomas NJ, Carcillo JA: Theophylline for acute renal vasoconstriction associated with tacrolimus: A new indication for an old therapeutic agent? Pediatr Crit Care Med 2003; 4:392-393
20. Schudt C, Hatzelmann A, Beume R., et al.: Phosphodiesterase inhibitors: History of pharmacology. Handb Exp Pharmacol 2011; 204:1-46
21. Schwertschlag US, Cerimele BJ, McNay J.L., et al.: Effect of tibenel-ast (a phosphodiesterase inhibitor) and theophylline on isoproter-enol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology 1993; 46:142-147
22. Jenik AG, Ceriani Cernadas JM, Gorenstein A, et al.: A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics 2000; 105:E45
23. Bakr AF: Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia-A study in a developing country. Pediatr Nephrol 2005; 20:1249-1252
24. Bhat MA, Shah ZA, Makhdoomi M.S., et al.: Theophylline for renal function in term neonates with perinatal asphyxia: A randomized, placebo-controlled trial. J Pediatr 2006; 149:180-184
25. Cattarelli D, Spandrio M, Gasparoni A., et al.: A randomised, double blind, placebo controlled trial of the effect of theophylline in prevention of vasomotor nephropathy in very preterm neonates with respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed 2006; 91:F80-F84
26. Bell M, Jackson E, Mi Z., et al.: Low-dose theophylline increases urine output in diuretic-dependent critically ill children. Intensive Care Med 1998; 24:1099-1105
27. Lochan SR, Adeniyi-Jones S, Assadi F.K., et al.: Coadministration of theophylline enhances diuretic response to furosemide in infants during extracorporeal membrane oxygenation: A randomized controlled pilot study. J Pediatr 1998; 133:86-89
28. Huet F, Semama D, Grimaldi M., et al.: Effects of theophylline on renal insufficiency in neonates with respiratory distress syndrome. Intensive Care Med 1995; 21:511-514
29. McLaughlin GE, Land MP, Rossique-Gonzalez M: Effect of amino-phylline on urine flow in children with tacrolimus-induced renal insuf-ficiency. Transplant Proc 2000; 32:817-820
30. McLaughlin GE, Abitbol CL: Reversal of oliguric tacrolimus nephro-toxicity in children. Nephrol Dial Transplant 2005; 20:1471-1475
31. Section 2: AKI definition. Kidney Int Suppl 2012; 2:19-36
32. Ng GY, Baker EH, Farrer KF: Aminophylline as an adjunct diuretic for neonates - A case series. Pediatr Nephrol 2005; 20:220-222
33. Mazkereth R, Laufer J, Jordan S., et al.: Effects of theophylline on renal function in premature infants. Am J Perinatol 1997; 14:45-49
34. Wernovsky G, Wypij D, Jonas R.A., et al.: Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary bypass and circulatory arrest. Circulation 1995; 92:2226-2235
35. Schwartz GJ, Brion LP, Spitzer A: The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 1987; 34:571-590
36. Cotter G, Dittrich HC, Weatherley B.D., et al.; Protect Steering Committee, Investigators, and Coordinators: The PROTECT pilot study: A randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment. J Card Fail 2008; 14:631-640
37. Mulla H, Nabi F, Nichani S., et al.: Population pharmacokinetics of theophylline during paediatric extracorporeal membrane oxygenation. Br J Clin Pharmacol 2003; 55:23-31
38. Pretzlaff RK, Vardis RJ, Pollack MM: Aminophylline in the treatment of fluid overload. Crit Care Med 1999; 27:2782-2785
39. National Asthma Education and Prevention Program TEP on the D and M of A (2007) Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Available at: http://www-ncbi-nlm-nih-gov.laneproxy.stanford.edu/books/ NBK7232/. Accessed 22 January 2013
40. Mehta RL, Kellum JA, Shah S.V., et al.; Acute Kidney Injury Network: Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11:R31