PKCα negatively regulates in vitro proplatelet formation and in vivo platelet production in mice

Platelets

Volumn 25, Issue 1, 2014, Pages 62-68

  Williams, Christopher M ^a   Harper, Matthew T ^a   Poole, Alastair W ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Megakaryocyte; PKC; Polyploidy; Proplatelet formation

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; PROTEIN KINASE C ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE THROMBOCYTOPENIA; CELL MATURATION; CONTROLLED STUDY; ENDOMITOSIS; FETUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEGAKARYOCYTE; MITOSIS; MOUSE; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN FUNCTION; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS;

ANIMALS; BLOOD PLATELETS; MEGAKARYOCYTES; MICE; MICE, TRANSGENIC; POLYPLOIDY; PROTEIN KINASE C-ALPHA;

EID: 84892717500     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2012.761686     Document Type: Article

References (22)

1. Harper MT, Poole AW. Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation. J Thromb Haemost 2010;8: 454-462.
2. Long MW, Smolen JE, Szczepanski P, Boxer LA. Role of phorbol diesters in in vitro murine megakaryocyte colony formation. J Clin Invest 1984;74: 1686-1692.
3. Lumelsky NL, Schwartz BS. Protein kinase C in erythroid and megakaryocytic differentiation: Possible role in lineage determination. Biochim Biophys Acta 1997;1358: 79-92.
4. Long MW, Heffner CH, Williams JL, Peters C, Prochownik EV. Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest 1990;85: 1072-1084.
5. Jiang F, Jia Y, Cohen I. Fibronectin- and protein kinase Cmediated activation of ERK/MAPK are essential for proplateletlike formation. Blood 2002;99: 3579-3584.
6. Minamiguchi H, Kimura T, Urata Y, Miyazaki H, Bamba T, Abe T, Sonoda Y. Simultaneous signalling through c-mpl, c-kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: Possible roles of the PI3-K, PKC and MAPK pathways. Br J Haematol 2001;115: 175-185.
7. Rojnuckarin P, Kaushansky K. Actin reorganization and proplatelet formation in murine megakaryocytes: The role of protein kinase C{alpha}. Blood 2001;97: 154-161.
8. Gobbi G, Mirandola P, Sponzilli I, Micheloni C, Malinverno C, Cocco L, Vitale M. Timing and expression level of PKC{varepsilon} regulate the megakaryocytic differentiation of human CD34 cells. Stem Cells 2007;25: 2322-2329.
9. Oshevski S, Le Bousse-Kerdiles M-C, Clay D, Levashova Z, Debili N, Vitral N, Jasmin C, Castagna M. Differential expression of protein kinase C isoform transcripts in human hematopoietic progenitors undergoing differentiation. Biochem Biophys Res Commun 1999;263: 603-609.
10. Goldfarb AN, Delehanty LL, Wang D, Racke FK, Hussaini IM. Stromal inhibition of megakaryocytic differentiation correlates with blockade of signaling by protein kinase C-" and ERK/ MAPK. J Biol Chem 2001;276: 29526-29530.
11. Murray NR, Baumgardner GP, Burns DJ, Fields AP. Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation. J Biol Chem 1993;268: 15847-15853.
12. Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JMEM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, et al. PKC- regulates platelet granule secretion and thrombus formation in mice. J Clin Invest 2009;119: 399-407.
13. Larson MK, Watson SP. Regulation of proplatelet formation and platelet release by integrin {alpha}IIbbeta3. Blood 2006;108: 1509-1514.
14. Mazharian A, Watson SP, Séverin S. Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation. Exp Hematol 2009;37: 1238-1249.e5.
15. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marmé D, Schächtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem 1993;268: 9194-9197.
16. Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, et al. PKC-[alpha] regulates cardiac contractility and propensity toward heart failure. Nat Med 2004;10: 248-254.
17. Harper MT, Poole AW. Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation. J Thromb Haemost 2010;8: 454-462.
18. Parker PJ, Murray-Rust J. PKC at a glance. J Cell Sci 2004;117: 131-132.
19. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 2000;279:L429-438.
20. Dhanjal TS, Pendaries C, Ross EA, Larson MK, Protty MB, Buckley CD, Watson SP. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 2007;109: 4237-4244.
21. Lordier L, Jalil A, Aurade F, Larbret F, Larghero J, Debili N, Vainchenker W, Chang Y. Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling. Blood 2008;112: 3164-3174.
22. Mehta D, Rahman A, Malik AB. Protein kinase C - signals rhoguanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J Biol Chem 2001;276: 22614-22620.