메뉴 건너뛰기




Volumn 13, Issue 2, 2014, Pages 247-253

Denosumab in osteoporosis

Author keywords

Denosumab; Efficacy; Fractures; Osteoporosis; Safety

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; DENOSUMAB;

EID: 84892697088     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2014.860133     Document Type: Article
Times cited : (41)

References (47)
  • 1
    • 84892683337 scopus 로고    scopus 로고
    • Highlights of prescribing information
    • [Last accessed 26 May 2013]
    • Highlights of prescribing information. Prolia (denosumab) Available from: http://pi.amgen.com/united-states/prolia/ prolia-pi.pdf [Last accessed 26 May 2013]
    • Prolia (Denosumab)
  • 2
    • 84862494590 scopus 로고    scopus 로고
    • A single-dose study of denosumab in patients with various degrees of renal impairment
    • Block GA, Bone HG, Fang L, et al. A single-dose study of denosumab in patients with various degrees of renal impairment. J Bone Miner Res 2012;27:1471-9
    • (2012) J Bone Miner Res , vol.27 , pp. 1471-1479
    • Block, G.A.1    Bone, H.G.2    Fang, L.3
  • 3
    • 69049083492 scopus 로고    scopus 로고
    • Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    • Cummings SR, San Martin J, McClung MR, et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009;361:756-65
    • (2009) N Engl J Med , vol.361 , pp. 756-765
    • Cummings, S.R.1    San Martin, J.2    McClung, M.R.3
  • 4
    • 84863116813 scopus 로고    scopus 로고
    • Five years of denosumab exposure in women with postmenopausal osteoporosis: Results from the first two years of the FREEDOM extension
    • Papapoulos S, Chapurlat R, Libanati C, et al. Five years of denosumab exposure in women with postmenopausal osteoporosis: results from the first two years of the FREEDOM extension. J Bone Miner Res 2012;27:694-701
    • (2012) J Bone Miner Res , vol.27 , pp. 694-701
    • Papapoulos, S.1    Chapurlat, R.2    Libanati, C.3
  • 5
    • 58149099647 scopus 로고    scopus 로고
    • Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, phase 3 trial
    • Brown JP, Prince RL, Deal C, et al. Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J Bone Miner Res 2009;24: 153-61
    • (2009) J Bone Miner Res , vol.24 , pp. 153-161
    • Brown, J.P.1    Prince, R.L.2    Deal, C.3
  • 6
    • 77953454405 scopus 로고    scopus 로고
    • Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy
    • Kendler DL, Roux C, Benhamou CL, et al. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J Bone Miner Res 2010;25: 72-81
    • (2010) J Bone Miner Res , vol.25 , pp. 72-81
    • Kendler, D.L.1    Roux, C.2    Benhamou, C.L.3
  • 7
    • 79955117784 scopus 로고    scopus 로고
    • Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk
    • Boonen S, Adachi JD, Man Z, et al. Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk. J Clin Endocrinol Metab 2011;96:1727-36
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1727-1736
    • Boonen, S.1    Adachi, J.D.2    Man, Z.3
  • 8
    • 84555189287 scopus 로고    scopus 로고
    • Effect of denosumab treatment on the risk of fractures in subgroups of women with postmenopausal osteoporosis
    • McClung MR, Boonen S, Torring O, et al. Effect of denosumab treatment on the risk of fractures in subgroups of women with postmenopausal osteoporosis. J Bone Miner Res 2012;27:211-18
    • (2012) J Bone Miner Res , vol.27 , pp. 211-218
    • McClung, M.R.1    Boonen, S.2    Torring, O.3
  • 9
    • 54449084015 scopus 로고    scopus 로고
    • Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer
    • Ellis GK, Bone HG, Chlebowski R, et al. Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer. J Clin Oncol 2008;26: 4875-82
    • (2008) J Clin Oncol , vol.26 , pp. 4875-4882
    • Ellis, G.K.1    Bone, H.G.2    Chlebowski, R.3
  • 10
    • 69049105440 scopus 로고    scopus 로고
    • Denosumab in men receiving androgen-deprivation therapy for prostate cancer
    • Smith MR, Egerdie B, Hernandez Toriz N, et al. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med 2009;361: 745-55
    • (2009) N Engl J Med , vol.361 , pp. 745-755
    • Smith, M.R.1    Egerdie, B.2    Hernandez Toriz, N.3
  • 11
    • 84866160239 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of the effects of denosumab for the treatment of men with low bone mineral density
    • Orwoll E, Teglbjaerg CS, Langdahl BL, et al. A randomized, placebo-controlled study of the effects of denosumab for the treatment of men with low bone mineral density. J Clin Endocrinol Metab 2012;97:3161-9
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3161-3169
    • Orwoll, E.1    Teglbjaerg, C.S.2    Langdahl, B.L.3
  • 12
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999;397: 315-23
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3
  • 13
    • 84857364148 scopus 로고    scopus 로고
    • Infections in postmenopausal women with osteoporosis treated with denosumab or placebo: Coincidence or causal association?
    • Watts NB, Roux C, Modlin JF, et al. Infections in postmenopausal women with osteoporosis treated with denosumab or placebo: coincidence or causal association? Osteoporos Int 2012;23:327-37
    • (2012) Osteoporos Int , vol.23 , pp. 327-337
    • Watts, N.B.1    Roux, C.2    Modlin, J.F.3
  • 14
    • 79952360832 scopus 로고    scopus 로고
    • Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study
    • Fizazi K, Carducci M, Smith M, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet 2011;377: 813-22
    • (2011) Lancet , vol.377 , pp. 813-822
    • Fizazi, K.1    Carducci, M.2    Smith, M.3
  • 15
    • 79952761418 scopus 로고    scopus 로고
    • Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
    • Henry DH, Costa L, Goldwasser F, et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol 2011;29: 1125-32
    • (2011) J Clin Oncol , vol.29 , pp. 1125-1132
    • Henry, D.H.1    Costa, L.2    Goldwasser, F.3
  • 16
    • 79551568488 scopus 로고    scopus 로고
    • Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study
    • Stopeck AT, Lipton A, Body JJ, et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol 2010;28: 5132-9
    • (2010) J Clin Oncol , vol.28 , pp. 5132-5139
    • Stopeck, A.T.1    Lipton, A.2    Body, J.J.3
  • 17
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay N, Sarosi I, Dunstan CR, et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998;12: 1260-8
    • (1998) Genes Dev , vol.12 , pp. 1260-1268
    • Bucay, N.1    Sarosi, I.2    Dunstan, C.R.3
  • 18
    • 38349133382 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice
    • Morony S, Tintut Y, Zhang Z, et al. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation 2008;117: 411-20
    • (2008) Circulation , vol.117 , pp. 411-420
    • Morony, S.1    Tintut, Y.2    Zhang, Z.3
  • 19
    • 68449102008 scopus 로고    scopus 로고
    • Inhibition of receptor activator of NFkappaB ligand by denosumab attenuates vascular calcium deposition in mice
    • Helas S, Goettsch C, Schoppet M, et al. Inhibition of receptor activator of NFkappaB ligand by denosumab attenuates vascular calcium deposition in mice. Am J Pathol 2009;175: 473-8
    • (2009) Am J Pathol , vol.175 , pp. 473-478
    • Helas, S.1    Goettsch, C.2    Schoppet, M.3
  • 20
    • 84879661933 scopus 로고    scopus 로고
    • Osteoprotegerin as a marker of cardiovascular risk in patients on peritoneal dialysis
    • Janda K, Krzanowski M, Chowaniec E, et al. Osteoprotegerin as a marker of cardiovascular risk in patients on peritoneal dialysis. Pol Arch Med Wewn 2013;123: 149-55
    • (2013) Pol Arch Med Wewn , vol.123 , pp. 149-155
    • Janda, K.1    Krzanowski, M.2    Chowaniec, E.3
  • 21
    • 84873370469 scopus 로고    scopus 로고
    • Osteoprotegerin as a marker of atherosclerosis in diabetic patients
    • Augoulea A, Vrachnis N, Lambrinoudaki I, et al. Osteoprotegerin as a marker of atherosclerosis in diabetic patients. Int J Endocrinol 2013;2013:182060
    • (2013) Int J Endocrinol , vol.2013 , pp. 182060
    • Augoulea, A.1    Vrachnis, N.2    Lambrinoudaki, I.3
  • 22
    • 84871754710 scopus 로고    scopus 로고
    • Osteoprotegerin improves risk detection by traditional cardiovascular risk factors and hsCRP
    • Mogelvang R, Haahr-Pedersen S, Bjerre M, et al. Osteoprotegerin improves risk detection by traditional cardiovascular risk factors and hsCRP. Heart 2013;99: 106-10
    • (2013) Heart , vol.99 , pp. 106-110
    • Mogelvang, R.1    Haahr-Pedersen, S.2    Bjerre, M.3
  • 23
    • 84876136816 scopus 로고    scopus 로고
    • The role of osteoprotegerin in cardiovascular disease
    • Montagnana M, Lippi G, Danese E, Guidi GC. The role of osteoprotegerin in cardiovascular disease. Ann Med 2013;45: 254-64
    • (2013) Ann Med , vol.45 , pp. 254-264
    • Montagnana, M.1    Lippi, G.2    Danese, E.3    Guidi, G.C.4
  • 24
    • 84867606835 scopus 로고    scopus 로고
    • Correlation of plasma osteoprotegerin (OPG) and receptor activator of the nuclear factor kappaB ligand (RANKL) levels with clinical risk factors in patients with advanced carotid atherosclerosis
    • Giaginis C, Papadopouli A, Zira A, et al. Correlation of plasma osteoprotegerin (OPG) and receptor activator of the nuclear factor kappaB ligand (RANKL) levels with clinical risk factors in patients with advanced carotid atherosclerosis. Med Sci Monit 2012;18:CR597-604
    • (2012) Med Sci Monit , vol.18
    • Giaginis, C.1    Papadopouli, A.2    Zira, A.3
  • 25
    • 84883302865 scopus 로고    scopus 로고
    • Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease
    • Tousoulis D, Siasos G, Maniatis K, et al. Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease. Int J Cardiol 2013;167(5): 1924-8
    • (2013) Int J Cardiol , vol.167 , Issue.5 , pp. 1924-1928
    • Tousoulis, D.1    Siasos, G.2    Maniatis, K.3
  • 26
    • 2442492972 scopus 로고    scopus 로고
    • Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease
    • Kiechl S, Schett G, Wenning G, et al. Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease. Circulation 2004;109: 2175-80
    • (2004) Circulation , vol.109 , pp. 2175-2180
    • Kiechl, S.1    Schett, G.2    Wenning, G.3
  • 28
    • 84882287315 scopus 로고    scopus 로고
    • Severe symptomatic hypocalcaemia following a single dose of denosumab
    • McLachlan JM, Marx GM, Bridgman M. Severe symptomatic hypocalcaemia following a single dose of denosumab. Med J Aust 2013;199: 242-3
    • (2013) Med J Aust , vol.199 , pp. 242-243
    • McLachlan, J.M.1    Marx, G.M.2    Bridgman, M.3
  • 29
    • 84887114892 scopus 로고    scopus 로고
    • Identification of the risk factors associated with hypocalcemia induced by denosumab
    • Okada N, Kawazoe K, Teraoka K, et al. Identification of the risk factors associated with hypocalcemia induced by denosumab. Biol Pharm Bull 2013;36(10): 1622-6
    • (2013) Biol Pharm Bull , vol.36 , Issue.10 , pp. 1622-1626
    • Okada, N.1    Kawazoe, K.2    Teraoka, K.3
  • 30
    • 84878249027 scopus 로고    scopus 로고
    • Life-threatening hypocalcemia associated with denosumab in a patient with moderate renal insufficiency
    • Ungprasert P, Cheungpasitporn W, Srivali N, et al. Life-threatening hypocalcemia associated with denosumab in a patient with moderate renal insufficiency. Am J Emerg Med 2013;31:756e1-2
    • (2013) Am J Emerg Med , vol.31
    • Ungprasert, P.1    Cheungpasitporn, W.2    Srivali, N.3
  • 31
    • 34848841461 scopus 로고    scopus 로고
    • Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research
    • Khosla S, Burr D, Cauley J, et al. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2007;22:1479-91
    • (2007) J Bone Miner Res , vol.22 , pp. 1479-1491
    • Khosla, S.1    Burr, D.2    Cauley, J.3
  • 32
    • 77957666406 scopus 로고    scopus 로고
    • Effects of denosumab on bone histomorphometry: The FREEDOM and STAND studies
    • Reid IR, Miller PD, Brown JP, et al. Effects of denosumab on bone histomorphometry: the FREEDOM and STAND studies. J Bone Miner Res 2010;25:2256-65
    • (2010) J Bone Miner Res , vol.25 , pp. 2256-2265
    • Reid, I.R.1    Miller, P.D.2    Brown, J.P.3
  • 33
    • 79953897155 scopus 로고    scopus 로고
    • Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass
    • Bone HG, Bolognese MA, Yuen CK, et al. Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass. J Clin Endocrinol Metab 2011;96:972-80
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 972-980
    • Bone, H.G.1    Bolognese, M.A.2    Yuen, C.K.3
  • 34
    • 79951746928 scopus 로고    scopus 로고
    • Effects of denosumab on bone turnover markers in postmenopausal osteoporosis
    • Eastell R, Christiansen C, Grauer A, et al. Effects of denosumab on bone turnover markers in postmenopausal osteoporosis. J Bone Miner Res 2011;26: 530-7
    • (2011) J Bone Miner Res , vol.26 , pp. 530-537
    • Eastell, R.1    Christiansen, C.2    Grauer, A.3
  • 35
    • 78349249359 scopus 로고    scopus 로고
    • Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research
    • Shane E, Burr D, Ebeling PR, et al. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2010;25: 2267-94
    • (2010) J Bone Miner Res , vol.25 , pp. 2267-2294
    • Shane, E.1    Burr, D.2    Ebeling, P.R.3
  • 36
    • 84891034178 scopus 로고    scopus 로고
    • Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American society for bone and mineral research
    • doi: 10.1002/jbmr.1998
    • Shane E, Ebeling PR, Abrahamsen B, et al. Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American society for bone and mineral research. J Bone Miner Res 2013;doi: 10.1002/jbmr.1998
    • (2013) J Bone Miner Res
    • Shane, E.1    Ebeling, P.R.2    Abrahamsen, B.3
  • 37
    • 84892734254 scopus 로고    scopus 로고
    • [Last accessed 12 June 2013]
    • Available from: http://www.mhra.gov.uk/ Safetyinformation/ DrugSafetyUpdate/ CON239411 [Last accessed 12 June 2013]
  • 38
    • 84879408894 scopus 로고    scopus 로고
    • A Case of an Unusual Subtrochanteric Fracture in a Patient Receiving Denosumab
    • Paparodis R, Buehring B, Pelley E, Binkley N. A Case of an Unusual Subtrochanteric Fracture in a Patient Receiving Denosumab. Endocr Pract 2013;19(3):e64-8
    • (2013) Endocr Pract , vol.19 , Issue.3
    • Paparodis, R.1    Buehring, B.2    Pelley, E.3    Binkley, N.4
  • 39
    • 84871503489 scopus 로고    scopus 로고
    • Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing: Results from the FREEDOM trial
    • Adami S, Libanati C, Boonen S, et al. Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing: results from the FREEDOM trial. J Bone Joint Surg Am 2012;94: 2113-19
    • (2012) J Bone Joint Surg Am , vol.94 , pp. 2113-2119
    • Adami, S.1    Libanati, C.2    Boonen, S.3
  • 40
    • 79960028242 scopus 로고    scopus 로고
    • Effects of denosumab on fracture and bone mineral density by level of kidney function
    • Jamal SA, Ljunggren O, Stehman-Breen C, et al. Effects of denosumab on fracture and bone mineral density by level of kidney function. J Bone Miner Res 2011;26: 1829-35
    • (2011) J Bone Miner Res , vol.26 , pp. 1829-1835
    • Jamal, S.A.1    Ljunggren, O.2    Stehman-Breen, C.3
  • 41
    • 84875313834 scopus 로고    scopus 로고
    • Discontinuation of denosumab and associated fracture incidence: Analysis from the Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) Trial
    • Brown JP, Roux C, Torring O, et al. Discontinuation of denosumab and associated fracture incidence: analysis from the Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) Trial. J Bone Miner Res 2013;28:746-52
    • (2013) J Bone Miner Res , vol.28 , pp. 746-752
    • Brown, J.P.1    Roux, C.2    Torring, O.3
  • 42
    • 84879887680 scopus 로고    scopus 로고
    • Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: The DATA study randomised trial
    • Tsai JN, Uihlein AV, Lee H, et al. Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial. Lancet 2013;382:50-6
    • (2013) Lancet , vol.382 , pp. 50-56
    • Tsai, J.N.1    Uihlein, A.V.2    Lee, H.3
  • 43
    • 79952673181 scopus 로고    scopus 로고
    • Adherence, preference, and satisfaction of postmenopausal women taking denosumab or alendronate
    • Kendler DL, McClung MR, Freemantle N, et al. Adherence, preference, and satisfaction of postmenopausal women taking denosumab or alendronate. Osteoporos Int 2011;22: 1725-35
    • (2011) Osteoporos Int , vol.22 , pp. 1725-1735
    • Kendler, D.L.1    McClung, M.R.2    Freemantle, N.3
  • 44
    • 84857361266 scopus 로고    scopus 로고
    • Final results of the DAPS (Denosumab Adherence Preference Satisfaction) study: A 24- month, randomized, crossover comparison with alendronate in postmenopausal women
    • Freemantle N, Satram-Hoang S, Tang ET, et al. Final results of the DAPS (Denosumab Adherence Preference Satisfaction) study: a 24- month, randomized, crossover comparison with alendronate in postmenopausal women. Osteoporos Int 2012;23: 317-26
    • (2012) Osteoporos Int , vol.23 , pp. 317-326
    • Freemantle, N.1    Satram-Hoang, S.2    Tang, E.T.3
  • 45
    • 79951672053 scopus 로고    scopus 로고
    • Cost-effectiveness of Denosumab for the treatment of postmenopausal osteoporosis
    • Jonsson B, Strom O, Eisman JA, et al. Cost-effectiveness of Denosumab for the treatment of postmenopausal osteoporosis. Osteoporos Int 2011;22: 967-82
    • (2011) Osteoporos Int , vol.22 , pp. 967-982
    • Jonsson, B.1    Strom, O.2    Eisman, J.A.3
  • 46
    • 84873903305 scopus 로고    scopus 로고
    • Cost-effectiveness of denosumab in the treatment of postmenopausal osteoporotic women
    • Hiligsmann M, Boonen A, Dirksen CD, et al. Cost-effectiveness of denosumab in the treatment of postmenopausal osteoporotic women. Expert Rev Pharmacoecon Outcomes Res 2013;13: 19-28
    • (2013) Expert Rev Pharmacoecon Outcomes Res , vol.13 , pp. 19-28
    • Hiligsmann, M.1    Boonen, A.2    Dirksen, C.D.3
  • 47
    • 80052785237 scopus 로고    scopus 로고
    • Cost effectiveness of denosumab compared with oral bisphosphonates in the treatment of post-menopausal osteoporotic women in Belgium
    • Hiligsmann M, Reginster JY. Cost effectiveness of denosumab compared with oral bisphosphonates in the treatment of post-menopausal osteoporotic women in Belgium. Pharmacoeconomics 2011;29: 895-911
    • (2011) Pharmacoeconomics , vol.29 , pp. 895-911
    • Hiligsmann, M.1    Reginster, J.Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.