Does neonatal BCG vaccination prevent allergic disease in later life?

Archives of Disease in Childhood

Volumn 99, Issue 2, 2014, Pages 182-184

  Freyne, Bridget ^a,b,c   Curtis, Nigel ^a,b,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; PLACEBO;

ALLERGIC DISEASE; BCG VACCINATION; HUMAN; META ANALYSIS (TOPIC); NEWBORN CARE; NOTE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW (TOPIC);

ALLERGY; IMMUNOLOGY; INFECTIOUS DISEASES;

ASTHMA; BCG VACCINE; HUMANS; HYPERSENSITIVITY; INFANT, NEWBORN;

EID: 84892687564     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/archdischild-2013-305655     Document Type: Note

References (9)

1. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299:1259-60.
2. Rook GA. Review series on helminths, immune modulation and the hygiene hypothesis: the broader implications of the hygiene hypothesis. Immunology 2009;126:3-11.
3. Marchant A, Goetghebuer T, Ota MO, et al. Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guerin vaccination. J immunol 1999;163:2249-55.
4. Kleinnijenhuis J, Quintin J, Preijersc F, et al. Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci USA 2012;109:17537-42.
5. Steenhuis TJ, van Aalderen WM, Bloksma N, et al. Bacille-Calmette-Guerin vaccination and the development of allergic disease in children: a randomized, prospective, single-blind study. Clin Exp Allergy 2008;38:79-85.
6. Koppen S, de Groot R, Neijens HJ, et al. No epidemiological evidence for infant vaccinations to cause allergic disease. Vaccine 2004;22:3375-85.
7. Balicer RD, Grotto I, Mimouni M, et al. Is childhood vaccination associated with asthma? A meta-analysis of observational studies. Pediatrics 2007;120:e1269-77.
8. El-Zein M, Parent ME, Benedetti A, et al. Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies. Int J Epidemiol 2010;39:469-86.
9. Arnoldussen DL, Linehan M, Sheikh A. BCG vaccination and allergy: a systematic review and meta-analysis. J Allergy Clin Immunol 2011;127:246-53, 53 e1-21.