Isoleucine, leucine, methionine, and threonine effects on mammalian target of rapamycin signaling in mammary tissue

Journal of Dairy Science

Volumn 97, Issue 2, 2014, Pages 1047-1056

  Arriola Apelo, S I ^a   Singer, L M ^a   Lin, X Y ^b   McGilliard, M L ^a   St Pierre, N R ^c   Hanigan, M D ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b SHANDONG AGRICULTURAL UNIVERSITY   (China)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Essential amino acid; Mammalian target of rapamycin (mTOR); Mammary gland; Translation regulation

Indexed keywords

BOS; EUKARYOTA; MAMMALIA;

ISOLEUCINE; LEUCINE; METHIONINE; MILK PROTEIN; PROTEIN; PROTEIN S6; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; THREONINE;

ANIMAL; BOVINE; DRUG EFFECTS; EPITHELIUM CELL; FEMALE; GENETICS; LACTATION; METABOLISM; MILK; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UDDER;

ANIMALS; CATTLE; EPITHELIAL CELLS; FEMALE; ISOLEUCINE; LACTATION; LEUCINE; MAMMARY GLANDS, ANIMAL; METHIONINE; MILK; MILK PROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEINS; RIBOSOMAL PROTEIN S6; SIGNAL TRANSDUCTION; SIROLIMUS; THREONINE; TOR SERINE-THREONINE KINASES;

EID: 84892670694     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2013-7348     Document Type: Article

References (33)

1. Appuhamy J.A.D.R.N Regulatory roles of essential amino acids, energy, and insulin in mammary cell protein synthesis 2010, Virginia Polytechnic Institute and State University, Blacksburg, PhD Diss.
2. Appuhamy J.A.D.R.N., Bell A.L., Nayananjalie W.A.D., Escobar J., Hanigan M.D. Essential amino acids regulate both initiation and elongation of mRNA translation independent of insulin in MAC-T cells and bovine mammary tissue slices. J. Nutr. 2011, 141:1209-1215.
3. Appuhamy J.A.D.R.N., Knapp J.R., Becvar O., Escobar J., Hanigan M.D. Effects of jugular-infused lysine, methionine, and branched-chain amino acids on milk protein synthesis in high-producing dairy cows. J. Dairy Sci. 2011, 94:1952-1960.
4. Appuhamy J.A.D.R.N., Knoebel N.A., Nayananjalie W.A.D., Escobar J., Hanigan M.D. Isoleucine and leucine independently regulate mTOR signaling and protein synthesis in MAC-T cells and bovine mammary tissue slices. J. Nutr. 2012, 142:484-491.
5. Arriola Apelo S.I., Nayananjalie W.A.D.J., Appuhamy A.D.R.N., Hanigan M.D. mTOR independent model of protein synthesis regulation by essential amino acids in mammary epithelial cells. Page 247 in Energy and Protein Metabolism and Nutrition. 2010, Wageningen Academic Publishers, Wageningen, the Netherlands. M.G. Crovetto (Ed.).
6. Bequette B.J., Hanigan M.D., Calder A.G., Reynolds C.K., Lobley G.E., MacRae J.C. Amino acid exchange by the mammary gland of lactating goats when histidine limits milk production. J. Dairy Sci. 2000, 83:765-775.
7. Bohé J., Low J.F.A., Wolfe R.R., Rennie M.J. Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids. J. Physiol. 2001, 532:575-579.
8. 13C amino acids as internal standards. Rapid Commun. Mass Spectrom. 1999, 13:2080-2083.
9. Caraviello D.Z., Weigel K.A., Fricke P.M., Wiltbank M.C., Florent M.J., Cook N.B., Nordlund K.V., Zwald N.R., Rawson C.L. Survey of management practices on reproductive performance of dairy cattle on large US commercial farms. J. Dairy Sci. 2006, 89:4723-4735.
10. Davis S.R., Collier R.J., McNamara J.P., Head H.H., Sussman W. Effects of thyroxine and growth hormone treatment of dairy cows on milk yield, cardiac output and mammary blood flow. J. Anim. Sci. 1988, 66:70-79.
11. Dunlop E.A., Tee A.R. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cell. Signal. 2009, 21:827-835.
12. Hanigan M.D., Cant J.P., Weakley D.C., Beckett J.L. An evaluation of postabsorptive protein and amino acid metabolism in the lactating dairy cow. J. Dairy Sci. 1998, 81:3385-3401.
13. Hanigan M.D., Reynolds C.K., Humphries D.J., Lupoli B., Sutton J.D. A model of net amino acid absorption and utilization by the portal-drained viscera of the lactating dairy cow. J. Dairy Sci. 2004, 87:4247-4268.
14. Hristov A.N., Price W.J., Shafii B. A meta-analysis examining the relationship among dietary Factors, dry matter intake, and milk and milk protein yield in dairy cows. J. Dairy Sci. 2004, 87:2184-2196.
15. Johnson, R. 2012. Livestock, dairy, and poultry outlook: August 2012. LDPM-218. Accessed Dec. 5, 2013. http://www.ers.usda.gov/publications/ldpm-livestock,-dairy,-and-poultry-outlook/ldpm218.aspx.
16. Kimball S.R. Regulation of global and specific mRNA translation by amino acids. J. Nutr. 2002, 132:883-886.
17. Kimball S.R., Everson W.V., Flaim K.E., Jefferson L.S. Initiation of protein synthesis in a cell-free system prepared from rat hepatocytes. Am. J. Physiol. 1989, 256:C28-C34.
18. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
19. MacRae J.C., Bruce L.A., Brown D.S., Calder A.G. Amino acid use by the gastrointestinal tract of sheep given lucerne forage. Am. J. Physiol. 1997, 273:G1200-G1207.
20. Mahoney S.J., Dempsey J.M., Blenis J. Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. Prog. Mol. Biol. Transl. Sci. 2009, 90:53-107.
21. Moshel Y., Rhoads R.E., Barash I. Role of amino acids in translational mechanisms governing milk protein synthesis in murine and ruminant mammary epithelial cells. J. Cell. Biochem. 2006, 98:685-700.
22. Murgas Torrazza R., Suryawan A., Gazzaneo M.C., Orellana R.A., Frank J.W., Nguyen H.V., Fiorotto M.L., El-Kadi S., Davis T.A. Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J. Nutr. 2010, 140:2145-2152.
23. O'Connor P.M.J., Kimball S.R., Suryawan A., Bush J.A., Nguyen H.V., Jefferson L.S., Davis T.A. Regulation of neonatal liver protein synthesis by insulin and amino acids in pigs. Am. J. Physiol. Endocrinol. Metab. 2004, 286:E994-E1003.
24. Park C.S., Chandler P.T., Clark R.M. Optimum amino acid complement for protein synthesis by rat mammary cells in tissue culture. J. Dairy Sci. 1976, 59:1758-1763.
25. Prizant R.L., Barash I. Negative effects of the amino acids Lys, His, and Thr on S6K1 phosphorylation in mammary epithelial cells. J. Cell. Biochem. 2008, 105:1038-1047.
26. Raggio G., Pacheco D., Berthiaume R., Lobley G.E., Pellerin D., Allard G., Dubreuil P., Lapierre H. Effect of level of metabolizable protein on splanchnic flux of amino acids in lactating dairy cows. J. Dairy Sci. 2004, 87:3461-3472.
27. Redpath N.T., Foulstone E.J., Proud C.G. Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO J. 1996, 15:2291-2297.
28. Rius A.G., Appuhamy J.A.D.R.N., Cyriac J., Kirovski D., Becvar O., Escobar J., McGilliard M.L., Bequette B.J., Akers R.M., Hanigan M.D. Regulation of protein synthesis in mammary glands of lactating dairy cows by starch and amino acids. J. Dairy Sci. 2010, 93:3114-3127.
29. St-Pierre N.R., Weiss W.P. Technical note: Designing and analyzing quantitative factorial experiments. J. Dairy Sci. 2009, 92:4581-4588.
30. Toerien C.A., Trout D.R., Cant J.P. Nutritional stimulation of milk protein yield of cows is associated with changes in phosphorylation of mammary eukaryotic initiation factor 2 and ribosomal S6 kinase 1. J. Nutr. 2010, 140:285-292.
31. Wang X., Qiao S., Yin Y., Yue L., Wang Z., Wu G. A deficiency or excess of dietary threonine reduces protein synthesis in jejunum and skeletal muscle of young pigs. J. Nutr. 2007, 137:1442-1446.
32. Wek S.A., Zhu S., Wek R.C. The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with and is required for activation in response to starvation for different amino acids. Mol. Cell. Biol. 1995, 15:4497-4506.
33. Wolfe A.H., Patz J.A. Reactive nitrogen and human health: Acute and long-term implications. Ambio 2002, 31:120-125.