Risk factors for the development of gastrointestinal colonization with fluoroquinolone-resistant escherichia coli in residents of long-term care facilities

Journal of Infectious Diseases

Volumn 209, Issue 3, 2014, Pages 420-425

  Han, Jennifer H ^a,b,c   Maslow, Joel ^f   Han, Xiaoyan ^b,c   Xie, Sharon X ^b,c   Tolomeo, Pam ^b,c   Santana, Evelyn ^e   Carson, Lesley ^d   Lautenbach, Ebbing ^a,b,c  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b Biostatistics and Epidemiology   (United States)

^c Department of Biostatistics and Epidemiology ^*  (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f MORRISTOWN MEMORIAL HOSPITAL   (United States)

Author keywords

Escherichia coli; fluoroquinolones; long term care; resistance; risk factors

Indexed keywords

ESCHERICHIA COLI; FLUOROQUINOLONES; LONG-TERM CARE; RESISTANCE; RISK FACTORS;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CARRIER STATE; COHORT STUDIES; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FECES; FEMALE; FLUOROQUINOLONES; GASTROINTESTINAL TRACT; HUMANS; LONG-TERM CARE; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84892662558     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit471     Document Type: Article

References (24)

1. Jones AL, Dwyer LL, Bercovitz AR, Strahan GW. The National Nursing Home Survey: 2004 overview. Vital Health Stat 2009; 13:1-155.
2. Strausbaugh LJ, Joseph CL. The burden of infection in long-term care. Infect Control Hosp Epidemiol 2000; 21:674-9.
3. Esposito S, Leone S, Noviello S, Lanniello F, Fiore M. Antibiotic resistance in long-term care facilities. New Microbiol 2007; 30:326-31.
4. Viray M, Linkin D, Maslow JN, et al. Longitudinal trends in antimicrobial susceptibilities across long-term-care facilities: emergence of fluoroquinolone resistance. Infect Control Hosp Epidemiol 2005; 26:56-62.
5. O'Fallon E, Pop-Vicas A, D'Agata E. The emerging threat of multidrug-resistant gram-negative organisms in long-term care facilities. J Gerontol A Biol Sci Med Sci 2009; 64:138-41.
6. Das R, Perrelli E, Towle V, Van Ness PH, Juthani-Mehta M. Antimicrobial susceptibility of bacteria isolated from urine samples obtained from nursing home residents. Infect Control Hosp Epidemiol 2009; 30:1116-9.
7. Donskey CJ. Antibiotic regimens and intestinal colonization with antibiotic-resistant gram-negative bacilli. Clin Infect Dis 2006; 43 (Suppl 2): S62-9.
8. Richard P, Delangle MH, Raffi F, Espaze E, Richet H. Impact of fluoroquinolone administration on the emergence of fluoroquinolone-resistant gram-negative bacilli from gastrointestinal flora. Clin Infect Dis 2001; 32:162-6.
9. Maslow JN, Lee B, Lautenbach E. Fluoroquinolone-resistant Escherichia coli carriage in long-term care facility. Emerg Infect Dis 2005; 11:889-94.
10. Muder RR, Brennen C, Goetz AM, Wagener MM, Rihs JD. Association with prior fluoroquinolone therapy of widespread ciprofloxacin resistance among gram-negative isolates in a Veterans Affairs medical center. Antimicrob Agents Chemother 1991; 35:256-8.
11. Fisch J, Lansing B,Wang L, et al. New acquisition of antibiotic-resistant organisms in skilled nursing facilities. J Clin Microbiol 2012; 50: 1698-703.
12. Nicolle LE, Bentley DW, Garibaldi R, Neuhaus EG, Smith PW. Antimicrobial use in long-term-care facilities. SHEA Long-Term-Care Committee. Infect Control Hosp Epidemiol 2000; 21:537-45.
13. Pakyz AL, Dwyer LL. Prevalence of antimicrobial use among United States nursing home residents: results from a national survey. Infect Control Hosp Epidemiol 2010; 31:661-2.
14. Rooney PJ, O'Leary MC, Loughrey AC, et al. Nursing homes as a reservoir of extended-spectrum beta-lactamase (ESBL)-producing ciprofloxacin-resistant Escherichia coli. J Antimicrob Chemother 2009; 64: 635-41.
15. Lautenbach E, Fishman NO, Metlay JP, et al. Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: results from a large hospital-based surveillance initiative. J Infect Dis 2006; 194:79-85.
16. Lautenbach E, Metlay JP, Weiner MG, et al. Gastrointestinal tract colonization with fluoroquinolone-resistant Escherichia coli in hospitalized patients: changes over time in risk factors for resistance. Infect Control Hosp Epidemiol 2009; 30:18-24.
17. Chang TM, Lu PL, Li HH, Chang CY, Chen TC, Chang LL. Characterization of fluoroquinolone resistance mechanisms and their correlation with the degree of resistance to clinically used fluoroquinolones among Escherichia coli isolates. J Chemother 2007; 19:488-94.
18. Singh R, Swick MC, Ledesma KR, et al. Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Antimicrob Agents Chemother 2012; 56:1680-5.
19. Kern WV, Oethinger M, Jellen-Ritter AS, Levy SB. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother 2000; 44:814-20.
20. Gales AC, Gordon KA, Wilke WW, Pfaller MA, Jones RN. Occurrence of single-point gyrA mutations among ciprofloxacin-susceptible Escherichia coli isolates causing urinary tract infections in Latin America. Diagn Microbiol Infect Dis 2000; 36:61-4.
21. Mickey RM, Greenland S. The impact of confounder selection criteria on effect estimation. Am J Epidemiol 1989; 129:125-37.
22. Daneman N, Gruneir A, Newman A, et al. Antibiotic use in long-term care facilities. J Antimicrob Chemother 2011; 66:2856-63.
23. Tsan L, Langberg R, Davis C, et al. Nursing home-associated infections in Department of Veterans Affairs community living centers. Am J Infect Control 2010; 38:461-6.
24. Mody L, Maheshwari S, Galecki A, Kauffman CA, Bradley SF. Indwelling device use and antibiotic resistance in nursing homes: identifying a high-risk group. J Am Geriatr Soc 2007; 55:1921-6.