Evaluating genetic counseling for individuals with schizophrenia in the molecular age

Schizophrenia Bulletin

Volumn 40, Issue 1, 2014, Pages 78-87

  Costain, Gregory ^a,b   Esplen, Mary Jane ^c,d   Toner, Brenda ^a,b,c   Scherer, Stephen W ^b,e   Meschino, Wendy S ^f   Hodgkinson, Kathleen A ^g   Bassett, Anne S ^a,b,c,h  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d TORONTO GENERAL HOSPITAL   (Canada)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f NORTH YORK GENERAL HOSPITAL   (Canada)

^g MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^h UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

copy number variation; genetic counseling; genetic predisposition to disease; genetics; schizophrenia; stigma

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CLINICAL PRACTICE; COHORT ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; EVIDENCE BASED PRACTICE; FEMALE; FOLLOW UP; GENETIC COUNSELING; GENETIC VARIABILITY; GENETICS; HUMAN; KNOWLEDGE; MALE; MEDICAL LITERATURE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RECURRENCE RISK; RECURRENT DISEASE; SCHIZOPHRENIA; STIGMA; STUDY DESIGN;

COPY NUMBER VARIATION; GENETIC COUNSELING; GENETIC PREDISPOSITION TO DISEASE; GENETICS; SCHIZOPHRENIA; STIGMA;

ADULT; CLINICAL PROTOCOLS; CONSUMER SATISFACTION; FEMALE; FOLLOW-UP STUDIES; GENETIC COUNSELING; GENETIC TESTING; GUILT; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; MALE; MIDDLE AGED; RECURRENCE; SCHIZOPHRENIA; SOCIAL STIGMA;

EID: 84892648059     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbs138     Document Type: Article

References (40)

1. Costain G, Bassett AS. Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era. Appl Clin Genet. 2012;5:1-18.
2. Bassett AS, Lionel AC, Costain G, et al. The burden of rare copy number variants in community-based schizophrenia suggests a potential role for clinical microarrays. 2012. In review.
3. Austin JC, Honer WG. The genomic era and serious mental illness: a potential application for psychiatric genetic counseling. Psychiatr Serv. 2007;58:254-261.
4. Bassett AS, Chow EWC, Hodgkinson KA. Genetics of schizophrenia and psychotic disorders. In: Smoller JW, Rosen Sheidley B, Tsuang MT, eds. Psychiatric Genetics: Applications in Clinical Practice. Arlington, VA: American Psychiatric Publishing, Inc.; 2008:99-130.
5. Hodgkinson KA, Murphy J, O'Neill S, Brzustowicz L, Bassett AS. Genetic counselling for schizophrenia in the era of molecular genetics. Can J Psychiatry. 2001;46:123-130.
6. Tsuang MT. Genetic counseling for psychiatric patients and their families. Am J Psychiatry. 1978;135:1465-1475.
7. DeLisi LE, Bertisch H. A preliminary comparison of the hopes of researchers, clinicians, and families for the future ethical use of genetic findings on schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:110-115.
8. Lyus VL. The importance of genetic counseling for individuals with schizophrenia and their relatives: potential clients' opinions and experiences. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:1014-1021.
9. Schulz PM, Schulz SC, Dibble E, Targum SD, van Kammen DP, Gershon ES. Patient and family attitudes about schizophrenia: implications for genetic counseling. Schizophr Bull. 1982;8:504-513.
10. Gottesman II, Wolfgram DL. Schizophrenia Genesis: The Origins of Madness. New York, NY: Freeman; 1991.
11. Reed SC. Counseling in Medical Genetics. 3rd ed. New York, NY: A. R. Liss; 1980.
12. Costain G, Esplen MJ, Toner B, Hodgkinson KA, Bassett AS. Evaluating genetic counseling for family members of individuals with schizophrenia in the molecular age. Schizophr Bull. 2012. doi:10.1093/schbul/sbs124.
13. Esplen MJ, Hunter J, Leszcz M, et al. A multicenter study of supportive-expressive group therapy for women with BRCA1/BRCA2 mutations. Cancer. 2004;101:2327-2340.
14. Lerman C, Lustbader E, Rimer B, et al. Effects of individualized breast cancer risk counseling: a randomized trial. J Natl Cancer Inst. 1995;87:286-292.
15. Scheuner MT, Sieverding P, Shekelle PG. Delivery of genomic medicine for common chronic adult diseases: a systematic review. JAMA. 2008;299:1320-1334.
16. Finn CT, Wilcox MA, Korf BR, et al. Psychiatric genetics: a survey of psychiatrists' knowledge, opinions, and practice patterns. J Clin Psychiatry. 2005;66:821-830.
17. Hoop JG, Roberts LW, Green Hammond KA, Cox NJ. Psychiatrists' attitudes regarding genetic testing and patient safeguards: a preliminary study. Genet Test. 2008;12:245-252.
18. Hunter MJ, Hippman C, Honer WG, Austin JC. Genetic counseling for schizophrenia: a review of referrals to a provincial medical genetics program from 1968 to 2007. Am J Med Genet A. 2010;152A:147-152.
19. Bassett AS, Chow EW, Waterworth DM, Brzustowicz L. Genetic insights into schizophrenia. Can J Psychiatry. 2001;46:131-137.
20. Feret H, Conway L, Austin JC. Genetic counselors' attitudes towards individuals with schizophrenia: desire for social distance and endorsement of stereotypes. Patient Educ Couns. 2011;82:69-73.
21. Martin N, Mikhaelian M, Cytrynbaum C, et al. 22q11.2 Deletion Syndrome: attitudes towards disclosing the risk of psychiatric illness. J Genet Counsel. 2012. doi:10.1007/s10897-012-9517-7
22. Bennett L, Thirlaway K, Murray AJ. The stigmatising implications of presenting schizophrenia as a genetic disease. J Genet Couns. 2008;17:550-559.
23. Pescosolido BA, Martin JK, Long JS, Medina TR, Phelan JC, Link BG. "A disease like any other" A decade of change in public reactions to schizophrenia, depression, and alcohol dependence. Am J Psychiatry. 2010;167:1321-1330.
24. Bassett AS, Costain G, Fung WL, et al. Clinically detectable copy number variations in a Canadian catchment population of schizophrenia. J Psychiatr Res. 2010;44:1005-1009.
25. Matheson SL, Shepherd AM, Laurens KR, Carr VJ. A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia. Schizophr Res. 2011;133:133-142.
26. Austin JC, Peay HL. Applications and limitations of empiric data in provision of recurrence risks for schizophrenia: a practical review for healthcare professionals providing clinical psychiatric genetics consultations. Clin Genet. 2006;70:177-187.
27. Austin JC, Palmer CG, Rosen-Sheidley B, Veach PM, Gettig E, Peay HL. Psychiatric disorders in clinical genetics II: Individualizing recurrence risks. J Genet Couns. 2008;17:18-29.
28. Moss-Morris R, Weinman J, Petrie KJ, Horne R, Cameron LD, Buick D. The revised illness perception questionnaire (R-IPQ). Psychol Health. 2002;17:1-16.
29. Ritsher JB, Otilingam PG, Grajales M. Internalized stigma of mental illness: psychometric properties of a new measure. Psychiatry Res. 2003;121:31-49.
30. Kondel TK, Mortimer AM, Leeson VC, Laws KR, Hirsch SR. Intellectual differences between schizophrenic patients and normal controls across the adult lifespan. J Clin Exp Neuropsychol. 2003;25:1045-1056.
31. Harper PS. Practical Genetic Counselling. 7th ed. London, UK: Hodder Arnold; 2010.
32. Smerecnik CM, Mesters I, Verweij E, de Vries NK, de Vries H. A systematic review of the impact of genetic counseling on risk perception accuracy. J Genet Couns. 2009;18:217-228.
33. Lichtenstein P, Bjk C, Hultman CM, Scolnick E, Sklar P, Sullivan PF. Recurrence risks for schizophrenia in a Swedish national cohort. Psychol Med. 2006;36:1417-1425.
34. Trottier M, Roberts W, Drmic I, et al. Parents' Perspectives on Participating in Genetic Research in Autism. J Autism Dev Disord. 2012. doi: 10.1007/s10803-012-1592-y.
35. Costain G, Chow EW, Ray PN, Bassett AS. Caregiver and adult patient perspectives on the importance of a diagnosis of 22q11.2 deletion syndrome. J Intellect Disabil Res. 2012;56:641-651.
36. Xia J, Merinder LB, Belgamwar MR. Psychoeducation for schizophrenia. Cochrane Database Syst Rev. 2011:CD002831.
37. Winner JG, Goebert D, Matsu C, Mrazek DA. Training in psychiatric genomics during residency: a new challenge. Acad Psychiatry. 2010;34:115-118.
38. Cooksey JA, Forte G, Benkendorf J, Blitzer MG. The state of the medical geneticist workforce: findings of the 2003 survey of American Board of Medical Genetics certified geneticists. Genet Med. 2005;7:439-443.
39. Peay HL, Hooker GW, Kassem L, Biesecker BB. Family risk and related education and counseling needs: perceptions of adults with bipolar disorder and siblings of adults with bipolar disorder. Am J Med Genet A. 2009;149A:364-371.
40. Need AC, McEvoy JP, Gennarelli M, et al. Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia. Am J Hum Genet. 2012;91:303-312.