Comparative analysis of atypical Spitz tumors with heterozygous versus homozygous 9p21 deletions for clinical outcomes, histomorphology, BRAF mutation, and p16 expression

American Journal of Surgical Pathology

Volumn 38, Issue 5, 2014, Pages 638-645

  Yazdan, Pedram ^a   Cooper, Chelsea ^a   Sholl, Lauren Meldi ^a   Busam, Klaus ^a   Rademaker, Alfred ^a   Weitner, Bing Bing ^a   Obregon, Roxana ^a   Guitart, Joan ^a,b   Gerami, Pedram ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

9p21; Atypical nevi; BRAF; Fish; Melanoma; P16; Spitz nevi; Spitz tumor

Indexed keywords

B RAF KINASE; BRAF PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; CHILD; CHROMOSOME 9; CHROMOSOME DELETION; COMPARATIVE STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENETICS; HISTORY; HUMAN; INFANT; MALE; METABOLISM; MIDDLE AGED; MUTATION; NEVUS; PATHOLOGY; SKIN TUMOR; YOUNG ADULT;

ADOLESCENT; ADULT; CHILD; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 9; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; GENE DELETION; HISTORY, MEDIEVAL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; MALE; MIDDLE AGED; MUTATION; NEVUS, EPITHELIOID AND SPINDLE CELL; PROTO-ONCOGENE PROTEINS B-RAF; SKIN NEOPLASMS; YOUNG ADULT;

EID: 84892643832     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000160     Document Type: Article

References (12)

1. Bastian BC, LeBoit PE, Hamm H, et al. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res. 1998;58:2170-2175.
2. Bastian BC, Olshen AB, LeBoit PE, et al. Classifying melanocytic tumors based on DNA copy number changes. Am J Pathol. 2003;163:1765-1770.
3. Bastian BC, Wesselmann U, Pinkel D, et al. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol. 1999;113:1065-1069.
4. Bauer J, Bastian BC. Distinguishing melanocytic nevi from melanoma by DNA copy number changes: comparative genomic hybridization as a research and diagnostic tool. Dermatol Ther. 2006;19:40-49.
5. Gerami P, Wass A, Mafee M, et al. Fluorescence in situ hybridization for distinguishing nevoid melanomas from mitotically active nevi. Am J Surg Pathol. 2009;33:1783-1788.
6. Matsuta M, Imamura Y, Matsuta M, et al. Detection of numerical chromosomal aberrations in malignant melanomas using fluorescence in situ hybridization. J Cutan Pathol. 1997;24:201-205.
7. Shen L, Cooper C, Bajaj S, et al. Atypical spitz tumors with 6q23 deletions: a clinical, histological, and molecular study. Am J Dermatopathol. 2013;35:804-812.
8. Gerami P, Scolyer RA, Xu X, et al. Risk assessment for atypical spitzoid melanocytic neoplasms using FISH to identify chromosomal copy number aberrations. Am J Surg Pathol. 2013;37:676-684.
9. Gerami P, Jewell SS, Morrison LE, et al. Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am J Surg Pathol. 2009;33:1146-1156.
10. Gerami P, Li G, Pouryazdanparast P, et al. A highly specific and discriminatory FISH assay for distinguishing between benign and malignant melanocytic neoplasms. Am J Surg Pathol. 2012;36:808-817.
11. Da Forno PD, Pringle JH, Fletcher A, et al. BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance. Br J Dermatol. 2009;161:364-372.
12. Freedberg DE, Rigas SH, Russak J, et al. Frequent p16-independent inactivation of p14ARF in human melanoma. J Natl Cancer Inst. 2008;100:784-795.