Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient

Journal of Infectious Diseases

Volumn 209, Issue 3, 2014, Pages 345-349

  Pan, Dongli ^a   Kaye, Stephen B ^b   Hopkins, Mark ^b   Kirwan, Ruaidhri ^b   Hart, Ian J ^b   Coen, Donald M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

acyclovir; antiviral drug resistance; herpes simplex keratitits; herpes simplex virus; thymidine kinase

Indexed keywords

ACICLOVIR; GUANINE; THYMIDINE; THYMIDINE KINASE;

ANTIVIRAL RESISTANCE; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CASE REPORT; ENZYME ACTIVITY; GENOTYPE; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; HUMAN; IMMUNOCOMPETENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT BILATERAL HERPES SIMPLEX KERATITIS; RECURRENT INFECTION; VIRUS MUTANT; VIRUS STRAIN;

ACYCLOVIR; ANTIVIRAL DRUG RESISTANCE; HERPES SIMPLEX KERATITITS; HERPES SIMPLEX VIRUS; THYMIDINE KINASE;

ACYCLOVIR; ADULT; AMINO ACID SUBSTITUTION; ANTIVIRAL AGENTS; DNA, VIRAL; DRUG RESISTANCE, VIRAL; HERPESVIRUS 1, HUMAN; HUMANS; KERATITIS, HERPETIC; MALE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION, MISSENSE; PHOSPHORYLATION; POINT MUTATION; RECURRENCE; SEQUENCE ANALYSIS, DNA; THYMIDINE; THYMIDINE KINASE; VIRAL PROTEINS;

EID: 84892640433     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit437     Document Type: Article

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