Development and characterization of gene silencing DNA cages

Biomacromolecules

Volumn 15, Issue 1, 2014, Pages 276-282

  Fakhoury, Johans J ^a   McLaughlin, Christopher K ^a,b   Edwardson, Thomas W ^a   Conway, Justin W ^a   Sleiman, Hanadi F ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDES; CANCER THERAPY; DEGRADATION PATHWAYS; GENE KNOCK DOWN; MAMMALIAN CELLS; RNA INTERFERENCE; THERAPEUTIC STRATEGY; TUMOR DEVELOPMENT;

DNA; GENE EXPRESSION;

GENETIC ENGINEERING;

ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY DNA; DNA; DOUBLE STRANDED DNA; SINGLE STRANDED DNA;

ANIMAL CELL; ARTICLE; DNA CAGE; DNA STRAND; DNA STRUCTURE; DNA SYNTHESIS; GENE SILENCING; GROWTH CURVE; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE;

DNA; GENE SILENCING; HELA CELLS; HUMANS; LUCIFERASES, FIREFLY; RNA, SMALL INTERFERING; SEQUENCE ANALYSIS, DNA;

EID: 84892608410     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm401532n     Document Type: Article

References (27)

1. McLaughlin, C. K.; Hamblin, G. D.; Sleiman, H. F. Supramolecular DNA assembly Chem. Soc. Rev. 2011, 40, 5647-56
2. Fu, J.; Liu, M.; Liu, Y.; Yan, H. Spatially-interactive biomolecular networks organized by nucleic acid nanostructures Acc. Chem. Res. 2012, 45, 1215-26
3. Campolongo, M. J.; Tan, S. J.; Xu, J.; Luo, D. DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications Adv. Drug Delivery Rev. 2010, 62, 606-616
4. Smith, D.; Schuller, V.; Engst, C.; Radler, J.; Liedl, T. Nucleic acid nanostructures for biomedical applications Nanomedicine 2013, 8, 105-21
5. Hamblin, G. D.; Carneiro, K. M.; Fakhoury, J. F.; Bujold, K. E.; Sleiman, H. F. Rolling circle amplification-templated DNA nanotubes show increased stability and cell penetration ability J. Am. Chem. Soc. 2012, 134, 2888-91
6. Walsh, A. S.; Yin, H.; Erben, C. M.; Wood, M. J. A.; Turberfield, A. J. DNA cage delivery to mammalian cells ACS Nano 2011, 5, 5427-5432
7. Lee, H.; Lytton-Jean, A. K. R.; Chen, Y.; Love, K. T.; Park, A. I.; Karagiannis, E. D.; Sehgal, A.; Querbes, W.; Zurenko, C. S.; Jayaraman, M.; Peng, C. G.; Charisse, K.; Borodovsky, A.; Manoharan, M.; Donahoe, J. S.; Truelove, J.; Nahrendorf, M.; Langer, R.; Anderson, D. G. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery Nat. Nanotechnol. 2012, 7, 389-393
8. Keum, J.-W.; Ahn, J.-H.; Bermudez, H. Design, assembly, and activity of antisense DNA nanostructures Small 2011, 7, 3529-3535
9. Schuller, V. J.; Heidegger, S.; Sandholzer, N.; Nickels, P. C.; Suhartha, N. A.; Endres, S.; Bourquin, C.; Liedl, T. Cellular immunostimulation by CpG-sequence-coated DNA origami structures ACS Nano 2011, 5, 9696-9702
10. Li, J.; Pei, H.; Zhu, B.; Liang, L.; Wei, M.; He, Y.; Chen, N.; Li, D.; Huang, Q.; Fan, C. Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides ACS Nano 2011, 5, 8783-8789
11. Jiang, Q.; Song, C.; Nangreave, J.; Liu, X.; Lin, L.; Qiu, D.; Wang, Z.-G.; Zou, G.; Liang, X.; Yan, H.; Ding, B. DNA origami as a carrier for circumvention of drug resistance J. Am. Chem. Soc. 2012, 134, 13396-13403
12. Kim, K. R.; Kim, D. R.; Lee, T.; Yhee, J. Y.; Kim, B. S.; Kwon, I. C.; Ahn, D. R. Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells Chem Comm. 2013, 49, 2010-2
13. Modi, S.; M, G. S.; Goswami, D.; Gupta, G. D.; Mayor, S.; Krishnan, Y. A DNA nanomachine that maps spatial and temporal pH changes inside living cells Nat. Nanotechnol. 2009, 4, 325-30
14. Conway, J. W.; McLaughlin, C. K.; Castor, K. J.; Sleiman, H. DNA nanostructure serum stability: Greater than the sum of its parts Chem. Commun. 2013, 49, 1172-4
15. Edwardson, T. G. W.; Carneiro, K. M. M.; McLaughlin, C. K.; Serpell, C. J.; Sleiman, H. F. Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly Nat. Chem. 2013, 5, 868-875
16. Lo, P. K.; Karam, P.; Aldaye, F. A.; McLaughlin, C. K.; Hamblin, G. D.; Cosa, G.; Sleiman, H. F. Loading and selective release of cargo in DNA nanotubes with longitudinal variation Nat. Chem. 2010, 2, 319-28
17. Keum, J.-W.; Bermudez, H. Enhanced resistance of DNA nanostructures to enzymatic digestion Chem. Commun. 2009, 7036-7038
18. Davidson, B. L.; McCray, P. B., Jr. Current prospects for RNA interference-based therapies Nat. Rev.: Genet. 2011, 12, 329-40
19. DeVos, S. L.; Miller, T. M. Antisense oligonucleotides: Treating neurodegeneration at the level of RNA Neurotherapeutics 2013, 10, 486-97
20. Deleavey, G. F.; Watts, J. K.; Alain, T.; Robert, F.; Kalota, A.; Aishwarya, V.; Pelletier, J.; Gewirtz, A. M.; Sonenberg, N.; Damha, M. J. Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing Nucleic Acids Res. 2010, 38, 4547-4557
21. Oliveira, C. L.; Juul, S.; Jorgensen, H. L.; Knudsen, B.; Tordrup, D.; Oteri, F.; Falconi, M.; Koch, J.; Desideri, A.; Pedersen, J. S.; Andersen, F. F.; Knudsen, B. R. Structure of nanoscale truncated octahedral DNA cages: Variation of single-stranded linker regions and influence on assembly yields ACS Nano 2010, 4, 1367-76
22. Ferrari, N.; Bergeron, D.; Tedeschi, A. L.; Mangos, M. M.; Paquet, L.; Renzi, P. M.; Damha, M. J. Characterization of antisense oligonucleotides comprising 2′-deoxy-2′-fluoro-beta- d -arabinonucleic acid (FANA): Specificity, potency, and duration of activity Ann. N.Y. Acad. Sci. 2006, 1082, 91-102
23. Kanaori, K.; Tamura, Y.; Wada, T.; Nishi, M.; Kanehara, H.; Morii, T.; Tajima, K.; Makino, K. Structure and stability of the consecutive stereoregulated chiral phosphorothioate DNA duplex Biochemistry 1999, 38, 16058-66
24. Astriab-Fisher, A.; Fisher, M. H.; Juliano, R.; Herdewijn, P. Increased uptake of antisense oligonucleotides by delivery as double stranded complexes Biochem. Pharmacol. 2004, 68 (3) 403-7
25. Bielinska, A.; Shivdasani, R. A.; Zhang, L. Q.; Nabel, G. J. Regulation of gene expression with double-stranded phosphorothioate oligonucleotides Science 1990, 250, 997-1000
26. Kim, S. H.; Jeong, J. H.; Lee, S. H.; Kim, S. W.; Park, T. G. PEG conjugated VEGF siRNA for anti-angiogenic gene therapy J. Controlled Release 2006, 116, 123-9
27. Breunig, M.; Hozsa, C.; Lungwitz, U.; Watanabe, K.; Umeda, I.; Kato, H.; Goepferich, A. Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo J. Controlled Release 2008, 130, 57-63