Melatonin as potential candidate to prevent the toxicity induced by chemical warfare agents

Archives of Toxicology

Volumn 88, Issue 1, 2014, Pages 3-4

  Pita, René ^a   Marco Contelles, José ^b   Ramos, Eva ^c   Pino, Javier Del ^c   Romero, Alejandro ^c  

^a CBRN Defence School   (Spain)

^b INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CHEMICAL WARFARE AGENT; CHLORINE; CHLORMETHINE; FREE RADICAL; HYDROCHLORIC ACID; HYPOCHLOROUS ACID; MELATONIN; MUSTARD GAS; ORGANOPHOSPHATE; PHOSGENE; REACTIVE OXYGEN METABOLITE; STEROID;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BLISTER; BLOOD BRAIN BARRIER; BRONCHOSPASM; CELL MEMBRANE; CYTOTOXICITY; DRUG MEGADOSE; EDITORIAL; ENERGY METABOLISM; EXCITOTOXICITY; HUMAN; HYPOXIA; INFLAMMATION; LIPID PEROXIDATION; LUNG EDEMA; LUNG INJURY; MUSTARD; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SCAVENGING SYSTEM;

ANIMALS; ANTIOXIDANTS; CHEMICAL WARFARE AGENTS; HUMANS; MELATONIN; ORGANOPHOSPHATES; OXIDATIVE STRESS;

EID: 84892606392     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1111-8     Document Type: Editorial

References (18)

1. Collombet JM (2011) Nerve agent intoxication: recent neuropathophysiological findings and subsequent impact on medical management prospects. Toxicol Appl Pharmacol 255:229-241
2. Costa EJ, Lopes RH, Lamy-Freund MT (1995) Permeability of pure lipid bilayers to melatonin. J Pineal Res 19:123-126
3. Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR (2011) Melatonin-a pleiotropic, orchestrating regulator molecule. Prog Neurobiol 93:350-384
4. Hengstler JG, Bolt HM (2007) Induction and control of oxidative stress. Arch Toxicol 81:823-824
5. Jafari M (2007) Dose- and time-dependent effects of sulfur mustard on antioxidant system in liver and brain of rat. Toxicology 231:30-39
6. Korkmaz A, Yaren H, Topal T, Oter S (2006) Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation. Arch Toxicol 80:662-670
7. Korkmaz A, Tan DX, Reiter RJ (2008) Acute and delayed sulfur mustard toxicity; novel mechanisms and future studies. Interdiscip Toxicol 1:22-26
8. Mauriz JL, Collado PS, Veneroso C, Reiter RJ, Gonzalez-Gallego J (2012) A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives. J Pineal Res. doi: 10.1111/j.1600-079X. 2012.01014.x
9. Pohanka M, Sobotka J, Jilkova M, Stetina R (2011) Oxidative stress after sulfur mustard intoxication and its reduction by melatonin: efficacy of antioxidant therapy during serious intoxication. Drug Chem Toxicol 34:85-91
10. Reiter RJ, Tan DX, Manchester LC, Qi W (2001) Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 34:237-256
11. Rodriguez C, Mayo JC, Sainz RM, Antolín I, Herrera F, Martín V, Reiter RJ (2004) Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 36:1-9
12. Sadir S, Deveci S, Korkmaz A, Oter S (2007) Alpha-tocopherol, beta-carotene and melatonin administration protects cyclophosphamide-induced oxidative damage to bladder tissue in rats. Cell Biochem Funct 25:521-526
13. Seabra ML, Bignotto M, Pinto LR Jr, Tufik S (2000) Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res 29:193-200
14. Tan D, Chen L, Poeggeler B, Manchester L, Reiter R (1993) Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1:57-60
15. Tan DX, Manchester LC, Reiter RJ, Plummer BF, Hardies LJ, Weintraub ST, Shepherd AM (1998) A novel melatonin metabolite, cyclic 3-hydroxymelatonin: a biomarker of in vivo hydroxyl radical generation. Biochem Biophys Res Commun 253:614-620
16. Ucar M, Korkmaz A, Reiter RJ, Yaren H, Öter S, Kurt B, Topal T (2007) Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard. Toxicol Lett 173:124-131
17. Zavodnik IB, Lapshina EA, Zavodnik LB, Łabieniec M, Bryszewska M, Reiter RJ (2004) Hypochlorous acid-induced oxidative stress in Chinese hamster B14 cells: viability, DNA and protein damage and the protective action of melatonin. Mutat Res 559:39-48
18. Zhang L, Shen J, Gan ZY, He DK, Zhong ZY (2012) [Protective effect of melatonin in rats with phosgene-induced lung injury]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 30:834-838