Non-paraneoplastic voltage-gated calcium channels antibody-mediated cerebellar ataxia responsive to IVIG treatment

Journal of the Neurological Sciences

Volumn 336, Issue 1-2, 2014, Pages 169-170

  Rigamonti, Andrea ^a   Lauria, Giuseppe ^b   Stanzani, Lorenzo ^a   Mantero, Vittorio ^a   Andreetta, Francesca ^b   Salmaggi, Andrea ^a  

^a Alessandro Manzoni General Hospital   (Italy)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

Antibodies; Cerebellar ataxia; Eaton Lambert myasthenic syndrome; immuno mediated ataxia; Intravenous immunoglobulin; Voltage gated calcium channels

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUTAMATE DECARBOXYLASE ANTIBODY; IMMUNOGLOBULIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL ANTIBODY;

ADULT; ANTHRACOSIS; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; ATAXIA; ATAXIC GAIT; CASE REPORT; CEREBELLAR ATAXIA; CEREBROSPINAL FLUID LEVEL; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; COORDINATION DISORDER; DISEASE DURATION; DISEASE SEVERITY; DRUG UPTAKE; DYSARTHRIA; EATON LAMBERT SYNDROME; FOLLOW UP; GAIT DISORDER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG HILUS; LYMPH NODE; LYMPH NODE DISSECTION; LYMPHADENITIS; MALE; MIDDLE AGED; MOTOR COORDINATION; MOTOR UNIT POTENTIAL; MULTIPLE CYCLE TREATMENT; NERVE CONDUCTION; NERVE STIMULATION; NEUROLOGIC EXAMINATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PERONEUS NERVE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RATING SCALE; SLURRED SPEECH; SPEECH DISORDER; TIBIAL NERVE; TREATMENT DURATION; TREATMENT RESPONSE; ULNAR NERVE; VIDEO ASSISTED THORACOSCOPIC SURGERY; WALKING;

ANTIBODIES; CEREBELLAR ATAXIA; EATON-LAMBERT MYASTHENIC SYNDROME; IMMUNO-MEDIATED ATAXIA; INTRAVENOUS IMMUNOGLOBULIN; VOLTAGE-GATED CALCIUM CHANNELS;

AUTOANTIBODIES; CALCIUM CHANNELS; CEREBELLAR ATAXIA; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; LAMBERT-EATON MYASTHENIC SYNDROME; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84892567282     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2013.10.031     Document Type: Article

References (17)

1. V.A. Lennon, T.J. Kryzer, G.E. Griesmann, P.E. O'Suilleabhain, A.J. Windebank, and A. Woppmann et al. Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes N Engl J Med 332 22 1995 1467 1474
2. W.P. Mason, F. Graus, B. Lang, J. Honnorat, J.Y. Delattre, and F. Valldeoriola et al. Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome Brain 120 1997 1279 1300
3. F. Graus, B. Lang, P. Pozo-Rosich, A. Saiz, R. Casamitjana, and A. Vincent P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer Neurology 59 5 2002 764 766
4. L.M. Eaton, and E.H. Lambert Electromyography and electric stimulation of nerves in diseases of motor unit; observations on myasthenic syndrome associated with malignant tumors JAMA 163 1957 1117 1124
5. P.J. Lorenzoni, R.H. Scola, B. Lang, C.S. Kay, H.A. Teive, and P.A. Kowacs et al. Cerebellar ataxia in non-paraneoplastic Lambert-Eaton myasthenic syndrome J Neurol Sci 270 2008 194 196
6. M. Nakamura, I. Yabe, K. Sato, F. Nakano, H. Yaguchi, and S. Tsuji et al. Transient subacute cerebellar ataxia in a patient with Lambert-Eaton myasthenic syndrome after intracranial aneurysm surgery Clin Neurol Neurosurg 110 5 2008 480 483
7. K. Bürk, M. Wick, G. Roth, P. Decker, and R. Voltz Antineuronal antibodies in sporadic late-onset cerebellar ataxia J Neurol 257 1 2010 59 62
8. P. Trouillas, T. Takayanagi, M. Hallett, R.D. Currier, S.H. Subramony, and K. Wessel et al. International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome. The Ataxia Neuropharmacology Committee of the World Federation of Neurology J Neurol Sci 145 2 1997 205 211
9. T. Klockgether Sporadic ataxia with adult onset: classification and diagnostic criteria Lancet Neurol 9 1 2010 94 104
10. J.O. Dalmau, and M.R. Rosenfeld Paraneoplastic syndrome of the CNS Lancet 7 4 2009 327 340
11. T. Fukuda, M. Motomura, Y. Nakao, H. Shiraishi, T. Yoshimura, and K. Iwanaga et al. Reduction of P/Q-type calcium channels in the postmortem cerebellum of paraneoplastic cerebellar degeneration with Lambert-Eaton myasthenic syndrome Ann Neurol 53 1 2003 21 28
12. P.D. Clouston, C.B. Saper, T. Arbizu, I. Johnston, B. Lang, and J. Newsom-Davis et al. Paraneoplastic cerebellar degeneration III. Cerebellar degeneration, cancer, and the Lambert-Eaton myasthenic syndrome Neurology 42 10 1992 1944 1950
13. A.M. Blumenfeld, L.D. Recht, D.A. Chad, U. DeGirolami, T. Griffin, and K.A. Jaeckle Coexistence of Lambert-Eaton myasthenic syndrome and subacute cerebellar degeneration: differential effects of treatment Neurology 41 10 1991 1682 1685
14. G. Lauria, D. Pareyson, M.G. Pitzolu, and E. Bazzigaluppi Excellent response to steroid treatment in anti-GAD cerebellar ataxia Lancet Neurol 2 10 2003 634 635
15. T.E. Römkens, G.C. Kusters, M.G. Netea, and P.M. Netten Prevalence and clinical characteristics of insulin-treated, anti-GAD-positive, type 2 diabetic subjects in an outpatient clinical department of a Dutch teaching hospital Neth J Med 64 4 2006 114 118
16. J. Newsom-Davis Neuromuscular junction channelopathies: a brief overview Acta Neurol Bel 105 2005 181 186
17. A. Pinto, S. Gillard, F. Moss, K. Whyte, P. Brust, and M. Williams et al. Human autoantibodies specific for the alpha1A calcium channel subunit reduce both P-type and Q-type calcium currents in cerebellar neurons Proc Natl Acad Sci U S A 95 14 1998 8328 8333