Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death

Journal of Hepatology

Volumn 60, Issue 2, 2014, Pages 354-361

  Silva Gomes, Sandro ^a   Santos, Ana G ^a   Caldas, Carolina ^a   Silva, Cátia M ^a   Neves, João V ^a   Lopes, Joanne ^b   Carneiro, Fátima ^b,c   Rodrigues, Pedro N ^a,d   Duarte, Tiago L ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b Centro Hospitalar Universitário de São João   (Portugal)

^c University of Porto   (Portugal)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

8 Hydroxy 2 deoxyguanosine; Antioxidant; Hemochromatosis; Hepatocyte; Mito TEMPOL; Necrosis

Indexed keywords

FERRIC AMMONIUM CITRATE; FERRITIN; HEPCIDIN; IRON; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION; IRON OVERLOAD; LIVER CELL; LIVER INJURY; LIVER PROTECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

8-HYDROXY-2′-DEOXYGUANOSINE; 8-OHDG; AC; ALANINE AMINOTRANSFERASE; ALT; AMMONIUM CITRATE; ANTIOXIDANT; ANTIOXIDANT RESPONSE ELEMENT; ARE; ASPARTATE AMINOTRANSFERASE; AST; FAC; FERRIC AMMONIUM CITRATE; HEMOCHROMATOSIS; HEPATOCYTE; HEREDITARY HEMOCHROMATOSIS; HH; HOGG1; HUMAN 8-HYDROXYGUANINE DNA GLYCOSYLASE 1; MITO-TEMPOL; MITOCHONDRIAL PERMEABILITY TRANSITION; MPT; NECROSIS; PI; PROPIDIUM IODIDE; REACTIVE OXYGEN SPECIES; RER; ROS; ROUGH ENDOPLASMIC RETICULUM; SER; SMOOTH ENDOPLASMIC RETICULUM;

ANIMALS; ANTIOXIDANTS; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; HEPATOCYTES; IRON OVERLOAD; IRON, DIETARY; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; NF-E2-RELATED FACTOR 2; SPIN LABELS;

EID: 84892559263     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.09.004     Document Type: Article

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