Altered balance of the aminogram in patients with sepsis - The relation to mortality

Clinical Nutrition

Volumn 33, Issue 1, 2014, Pages 179-182

  Hirose, Tomoya ^a   Shimizu, Kentaro ^b   Ogura, Hiroshi ^a   Tasaki, Osamu ^c   Hamasaki, Toshimitsu ^a   Yamano, Shuhei ^c   Ohnishi, Mitsuo ^a   Kuwagata, Yasuyuki ^a   Shimazu, Takeshi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY HOSPITAL   (Japan)

^c NAGASAKI UNIVERSITY HOSPITAL   (Japan)

Author keywords

Amino acids; Glutamate; ICU; Methionine; Prognosis; Sepsis

Indexed keywords

ALANINE; ARGININE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; METHIONINE; ORNITHINE; PHENYLALANINE; SERINE; TAURINE; TRYPTOPHAN; TYROSINE;

ADULT; AGED; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; METABOLIC BALANCE; MORTALITY; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN HOMEOSTASIS; RETROSPECTIVE STUDY; SCORING SYSTEM; SEPSIS;

ACUTE PHYSIOLOGICAL AND CHRONIC HEALTH EVALUATION; AMINO ACIDS; APACHE; CART; CLASSIFICATION AND REGRESSION TREE; GLUTAMATE; ICU; INTENSIVE CARE UNIT; INTERQUARTILE RANGE; IQR; METHIONINE; PROGNOSIS; S-ADENOSYLMETHIONINE; SAM; SEPSIS; SEQUENTIAL ORGAN FAILURE ASSESSMENT; SOFA;

AGED; AMINO ACIDS; CRITICAL ILLNESS; FEMALE; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NUTRITIONAL REQUIREMENTS; RETROSPECTIVE STUDIES; SEPSIS;

EID: 84892553536     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.11.017     Document Type: Article

References (10)

1. Druml W., Heinzel G., Kleinberger G. Amino acid kinetics in patients with sepsis. Am J Clin Nutr 2001, 73:908-913.
2. De Bandt J.P., Cynober L. Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. JNutr 2006, 136(Suppl.1):308S-313S.
3. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20:864-874.
4. Fujiwara M., Ishida Y., Nimura N., Toyama A., Kinoshita T. Postcolumn fluorometric detection system for liquid chromatographic analysis of amino and imino acids using o-phthalaldehyde/N-acetyl-L-cysteine reagent. Anal Biochem 1987, 166:72-78.
5. Newsholme P., Procopio J., Lima M.M., Pithon-Curi T.C., Curi R. Glutamine and glutamate - their central role in cell metabolism and function. Cell Biochem Funct 2003, 21:1-9.
6. Oudemans-van Straaten H.M., Bosman R.J., Treskes M., van der Spoel H.J., Zandstra D.F. Plasma glutamine depletion and patient outcome in acute ICU admissions. Intensive Care Med 2001, 27:84-90.
7. Vinnars E., Bergstöm J., Fürst P. Influence of the postoperative state on the intracellular free amino acids in human muscle tissue. Ann Surg 1975, 182:665-671.
8. Finkelstein J.D. Methionine metabolism in mammals. JNutr Biochem 1990, 1:228-237.
9. Semmler A., Smulders Y., Struys E., Smith D., Moskau S., Blom H., et al. Methionine metabolism in an animal model of sepsis. Clin Chem Lab Med 2008, 46:1398-1402.
10. Dever J.T., Elfarra A.A. The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance. Expert Opin Drug Metab Toxicol 2010, 6:1333-1346.