Tiagabine-induced stupor - More evidence for an encephalopathy

Epilepsy and Behavior

Volumn 31, Issue , 2014, Pages 196-197

  Hamandi, K ^a   Myers, J ^b   Muthukumaraswamy, S ^c  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TIAGABINE;

ADULT; AMNESIA; ATAXIA; BODY MASS; BRAIN DISEASE; BRAIN TOXICITY; CASE REPORT; CLINICAL FEATURE; CONFUSION; CONTROLLED STUDY; DISEASE COURSE; DISORIENTATION; DIZZINESS; DRUG MECHANISM; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; FEMALE; GABAERGIC SYSTEM; HALLUCINATION; HUMAN; LETTER; MAGNETOENCEPHALOGRAPHY; MALE; MYOCLONUS; NAUSEA; NEUROPATHOLOGY; NEUROPHYSIOLOGY; PSYCHOGENIC NONEPILEPTIC SEIZURE; PSYCHOMETRY; SINGLE DRUG DOSE; SPEECH DISORDER; STUPOR; TREMOR; YOUNG ADULT;

ANTICONVULSANTS; FEMALE; HUMANS; MALE; NIPECOTIC ACIDS; STATUS EPILEPTICUS; STUPOR;

EID: 84892544827     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2013.12.027     Document Type: Letter

References (10)

1. Azar N.J., Bangalore-Vittal N., Arain A., Abou-Khalil B.W. Tiagabine-induced stupor in patients with psychogenic nonepileptic seizures: nonconvulsive status epilepticus or encephalopathyα. Epilepsy Behav 2013, 27:330-332.
2. Muthukumaraswamy S.D., Myers J.F., Wilson S.J., Nutt D.J., Hamandi K., Lingford-Hughes A., et al. Elevating endogenous GABA levels with GAT-1 blockade modulates evoked but not induced responses in human visual cortex. Neuropsychopharmacology 2013, 38:1105-1112.
3. Muthukumaraswamy S.D., Myers J.F., Wilson S.J., Nutt D.J., Lingford-Hughes A., Singh K.D., et al. The effects of elevated endogenous GABA levels on movement-related network oscillations. Neuroimage 2012, 66C:36-41.
4. Schuckit M.A. Self-rating of alcohol intoxication by young men with and without family histories of alcoholism. J Stud Alcohol 1980, 41:242-249.
5. Schapel G., Chadwick D. Tiagabine and non-convulsive status epilepticus. Seizure 1996, 5:153-156.
6. Cope D.W., Di Giovanni G., Fyson S.J., Orban G., Errington A.C., Lorincz M.L., et al. Enhanced tonic GABAA inhibition in typical absence epilepsy. Nat Med 2009, 15:1392-1398.
7. Knake S., Hamer H.M., Schomburg U., Oertel W.H., Rosenow F. Tiagabine-induced absence status in idiopathic generalized epilepsy. Seizure 1999, 8:314-317.
8. Eckardt K.M., Steinhoff B.J. Nonconvulsive status epilepticus in two patients receiving tiagabine treatment. Epilepsia 1998, 39:671-674.
9. Farrant M., Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci 2005, 6:215-229.
10. Brickley S.G., Mody I. Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease. Neuron 2012, 73:23-34.