Distraction osteogenesis in the treatment of long bone defects of the lower limbs: Effectiveness, complications and clinical results; a systematic review and meta-analysis

Bone and Joint Journal

Volumn 95 B, Issue 12, 2013, Pages 1673-1680

  Papakostidis, C ^a   Bhandari, M ^a,b   Giannoudis, P V ^a,c  

^a G HATZIKOSTA GENERAL HOSPITAL   (Greece)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DEFECT; COMPARATIVE STUDY; DISTRACTION OSTEOGENESIS; FOLLOW UP; FRACTURE HEALING; HUMAN; ILIZAROV TECHNIQUE; INFECTION RISK; LONG BONE; META ANALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK REDUCTION; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

EID: 84892503355     PISSN: None     EISSN: 20494408     Source Type: Journal    
DOI: 10.1302/0301-620X.95B12.32385     Document Type: Review

References (59)

1. Keating JF, Simpson AH, Robinson CM. The management of fractures with bone loss. J Bone Joint Surg [Br] 2005;87-B:142-150.
2. French B, Tornetta P 3rd. High-energy tibial shaft fractures. Orthop Clin North Am 2002;33:211-230.
3. Dorow C, Markgraf E. Therapy of soft tissue injuries: biological strategies. Zentralbl Chir 1997;122:962-969.
4. Gopal S, Majumder S, Batchelor AG, et al. Fix and flap: the radical orthopaedic and plastic treatment of severe open fractures of the tibia. J Bone Joint Surg [Br] 2000;82- B:959-966.
5. Agarwal S, Agarwal R, Jain UK, Chandra R. Management of soft-tissue problems in leg trauma in conjunction with application of the Ilizarov fixator assembly. Plast Reconstr Surg 2001;107:1732-1738.
6. Tsuchiya H, Tomita K. Distraction osteogenesis for treatment of bone loss in the lower extremity. J Orthop Sci 2003;8:116-124.
7. Thomsen PB, Siemssen SJ, Hall KV, Domholt V. Muscle transposition for treatment of osteomyelitis of the tibia. Scand J Plast Reconstr Surg 1985;19:81-85.
8. Lortat-Jacob A, Lelong P, Benoit J, Ramadier JO. Complementary surgical procedures following treatment of non-union by Papineau method. Rev Chir Orthop Reparatrice Appar Mot 1981;67:115-120 ( in French).
9. May JW Jr, Gallico GG 3rd, Lukash FN. Microvascular transfer of free tissue for closure of bone wounds of the distal lower extremity. N Engl J Med 1982;306:253-257.
10. Yaremchuk MJ, Brumback RJ, Manson PN, et al. Acute and definitive management of traumatic osteocutaneous defects of the lower extremity. Plast Reconstr Surg 1987;80:1-14.
11. Nusbickel FR, Dell PC, McAndrew MP, Moore MM. Vascularized autografts for reconstruction of skeletal defects following lower extremity trauma: a review. Clin Orthop Relat Res 1989;243:65-70.
12. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues. Part I: the influence of stability of fixation and soft-tissue preservation. Clin Orthop Relat Res 1989;238:249-281.
13. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: Part II: the influence of the rate and frequency of distraction. Clin Orthop Relat Res 1989;239:263- 285.
14. Aronson J. Current concepts review: Limb-lengthening, skeletal reconstruction, and bone transport with Ilizarov method. J Bone Joint Surg [Am] 1997;79-A:1243-1257.
15. Shea BJ, Grimshaw JM, Wells GA, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 2007;7:10.
16. Agresti A, Coul BA. Approximate is better than 'exact' for interval estimation of binomial proportions. Am Stat 1998;52:119-126.
17. Cochran WG. The combination of estimates from different experiments. Biometrics 1954;10:101-129.
18. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560.
19. Paley D, Catagni MA, Argnani F, et al. Ilizarov treatment of tibial nonunions with bone loss. Clin Orthop Relat Res 1989;241:146-165.
20. Green SA, Jackson JM, Wall DM, Marinow H, Ishkanian J. Management of segmental defects by the Ilizarov intercalary bone transport method. Clin Orthop Relat Res 1992;280:136-142.
21. Cattaneo R, Catagni M, Johnson EE. The treatment of infected nonunions and segmental defects of the tibia by the methods of Ilizarov. Clin Orthop Relat Res 1992;280:143-152.
22. Naggar L, Chevalley F, Blanc CH, Livio JJ. Treatment of large bone defects with the Ilizarov technique. J Trauma 1993;34:390-393.
23. Dendrinos GK, Kontos S, Lyritsis E. Use of the Ilizarov technique for treatment of non-union of the tibia associated with infection. J Bone Joint Surg [Am] 1995;77-A:835-846.
24. Lowenberg DW, Feibel RJ, Louie KW, Eshima I. Combined muscle flap and Ilizarov reconstruction for bone and soft tissue defects. Clin Orthop Relat Res 1996;332:37-51.
25. Polyzois D, Papachristou G, Kotsiopoulos K, Plessas S. Treatment of tibial and femoral bone loss by distraction osteogenesis: experience in 28 infected and 14 clean cases. Acta Orthop Scand Suppl 1997;275:84-88.
26. Atesalp AS, Basbozkurt M, Erler E, et al. Treatment of tibial bone defects with the Ilizarov circular external fixator in high-velocity gunshot wounds. Int Orthop 1998;22:343-347.
27. Ring D, Jupiter JB, Gan BS, Israeli R, Yaremchuk MJ. Infected nonunion of the tibia. Clin Orthop Relat Res 1999;369:302-311.
28. Paley D, Maar DC. Ilizarov bone transport treatment for tibial defects. J Orthop Trauma 2000;14:76-85.
29. Laursen MB, Lass P, Christensen KS. Ilizarov treatment of tibial nonunions results in 16 cases. Acta Orthop Belg 2000;66:279-285.
30. Maini L, Chadha M, Vishwanath J, et al. The Ilizarov method in infected nonunion of fractures. Injury 2000;31:509-517.
31. Sanders DW, Galpin RD, Hosseini M, MacLeod MD. Morbidity resulting from the treatment of tibial nonunion with the Ilizarov frame. Can J Surg 2002;45:196-200.
32. Bobroff GD, Gold S, Zinar D. Ten year experience with use of Ilizarov bone transport for tibial defects. Bull Hosp Jt Dis 2003;61:101-107.
33. Sen C, Kocaoglu M, Eralp L, Gulsen M, Cinar M. Bifocal compression-distraction in the acute treatment of grade III open tibia fractures with bone and soft-tissue loss: a report of 24 cases. J Orthop Trauma 2004;18:150-157.
34. Mahaluxmivala J, Nadarajah R, Allen PW, Hill RA. Ilizarov external fixator: acute shortening and lengthening versus bone transport in the management of tibial non-unions. Injury 2005;36:662-668.
35. Rozbruch SR, Weitzman AM, Watson TJ, et al. Simultaneous treatment of tibial bone and soft-tissue defects with the Ilizarov method. J Orthop Trauma 2006;20:197-205.
36. Abdel-Aal AM. Ilizarov bone transport for massive tibial bone defects. Orthopedics 2006;29:70-74.
37. Magadum MP, Basavaraj Yadav CM, Phaneesha MS, Ramesh LJ. Acute compression and lengthening by the Ilizarov technique for infected nonunion of the tibia with large bone defects. J Orthop Surg (Hong Kong) 2006;14:273-279.
38. Patil S, Montgomery R. Management of complex tibial and femoral nonunion using the Ilizarov technique, and its cost implications. J Bone Joint Surg [Br] 2006;88-B:928-932.
39. Krishnan A, Pamecha C, Patwa JJ. Modified Ilizarov technique for infected nonunion of the femur: the principle of distraction-compression osteogenesis. J Orthop Surg (Hong Kong) 2006;14:265-272.
40. Saridis A, Panagiotopoulos E, Tyllianakis M, et al. The use of the Ilizarov method as a salvage procedure in infected nonunion of the distal femur with bone loss. J Bone Joint Surg [Br] 2006;88-B:232-237.
41. Morasiewicz L, Orzechowski W, Kulej M, Stepniewski M. The results of treatment of bone defects and non-union within the femoral shaft with shortening of femur using Ilizarov method. Orthop Traumatol Rehabil 2007;9:366-376.
42. Rozbruch SR, Pugsley JS, Fragomen AT, Ilizarov S. Repair of tibial nonunions and bone defects with the Taylor Spatial Frame. J Orthop Trauma 2008;22:88-95.
43. McKee MD, Yoo DJ, Zdero R, et al. Combined single-stage osseous and soft tissue reconstruction of the tibia with the Ilizarov method and tissue transfer. J Orthop Trauma 2008;22:183-189.
44. Madhusudhan TR, Ramesh B, Manjunath K, et al. Outcomes of Ilizarov ring fixation in recalcitrant infected tibial non-unions: a prospective study. J Trauma Manag Outcomes 2008;2:6.
45. Oostenbroek HJ, Brand R, van Roermund PM. Lower limb deformity due to failed trauma treatment corrected with the Ilizarov technique: factors affecting the complication rate in 52 patients. Acta Orthop 2009;80:435-439.
46. Blum AL, BongioVanni JC, Morgan SJ, Flierl MA, dos Reis FB. Complications associated with distraction osteogenesis for infected nonunion of the femoral shaft in the presence of a bone defect: a retrospective series. J Bone Joint Surg [Br] 2010;92-B:565-570.
47. Hutson JJ Jr, Dayicioglu D, Oeltjen JC, Panthaki ZJ, Armstrong MB. The treatment of gustilo grade IIIB tibia fractures with application of antibiotic spacer, flap, and sequential distraction osteogenesis. Ann Plast Surg 2010;64:541-552.
48. Bumbasirević M, Tomić S, Lesić A, Milosević I, Atkinson HD. War-related infected tibial nonunion with bone and soft-tissue loss treated with bone transport using the Ilizarov method. Arch Orthop Trauma Surg 2010;130:739-749.
49. Sala F, Thabet AM, Castelli F, et al. Bone transport for post infectious segmental tibial bone defects with a combined ilizarov/taylor spatial frame technique. J Orthop Trauma 2011;25:162-168.
50. Cierny G 3rd, Zorn KE. Segmental tibial defects: comparing conventional and Ilizarov methodologies. Clin Orthop Relat Res 1994;301:118-123.
51. Song HR, Cho SH, Koo KH, et al. Tibial bone defects treated by internal bone transport using the Ilizarov method. Int Orthop 1998;22:293-297.
52. Smrke D, Arnež ZM. Treatment of extensive bone and soft tissue defects of the lower limb by traction and free-flap transfer. Injury 2000;31:153-162.
53. Barbarossa V, Matković BR, Vucić N, Bielen M, Gluhinić M. Treatment of osteomyelitis and infected nonunion of the femur by a modified Ilizarov technique: follow-up study. Croat Med J 2001;42:634-641.
54. Mekhail AO, Abraham E, Gruber B, Gonzalez M. Bone transport in the management of posttraumatic bone defects in the lower extremity. J Trauma 2004;56:368-378.
55. Chaddha M, Gulati D, Singh AP, Singh AP, Maini L. Management of massive post-traumatic bone defects in the lower limb with the Ilizarov technique. Acta Orthop Belg 2010;76:811-820.
56. Bhandari M, Morrow F, Kulkarni AV, Tornetta P 3rd. Meta analyses in orthopaedic surgery: a systematic review of their methodologies. J Bone Joint Surg [Am] 2001;83-A:15-24.
57. Egger M, Schneider M, Davey SG. Spurious precision? Meta-analysis of observational studies. BMJ 1998;316:140-144.
58. Montori VM, Swiontkowski MF, Cook DJ. Methodological issues in systematic reviews and meta-analyses. Clin Orthop Relat Res 2003;413:43-54.
59. Murlow CD. Rationale for systematic reviews. BMJ 1994;309:597-599.