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Volumn 8, Issue 3, 2013, Pages 180-204

Modulation of the TRPV1 channel: Current clinical trials and recent patents with focus on neurological conditions

Author keywords

Inflammation; Pain; TRPV1

Indexed keywords

CAPSAICIN; PARTIAL AGONIST; PIPERINE; RESINIFERATOXIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UREA DERIVATIVE; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 AGONIST; VANILLOID RECEPTOR 1 ANTAGONIST; VANILLOID RECEPTOR AGONIST;

EID: 84892492983     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574889808666131209124012     Document Type: Review
Times cited : (44)

References (282)
  • 2
    • 58149200910 scopus 로고    scopus 로고
    • Transient receptor potential channels: Targeting pain at the source
    • Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: Targeting pain at the source. Nat Rev Drug Discov 2009; 8: 55-68.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 55-68
    • Patapoutian, A.1    Tate, S.2    Woolf, C.J.3
  • 3
    • 34250190946 scopus 로고    scopus 로고
    • The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity
    • Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 2007; 54: 905-18.
    • (2007) Neuron , vol.54 , pp. 905-918
    • Lishko, P.V.1    Procko, E.2    Jin, X.3    Phelps, C.B.4    Gaudet, R.5
  • 6
    • 34547116182 scopus 로고    scopus 로고
    • Modulation of TRPs by PIPs
    • Voets T, Nilius B. Modulation of TRPs by PIPs. J Physiol 2007; 582: 939-44.
    • (2007) J Physiol , vol.582 , pp. 939-944
    • Voets, T.1    Nilius, B.2
  • 7
    • 77955569436 scopus 로고    scopus 로고
    • Transient receptor potential channelopathies
    • Nilius B, Owsianik G. Transient receptor potential channelopathies. Pflugers Arch 2010; 460: 437-50.
    • (2010) Pflugers Arch , vol.460 , pp. 437-450
    • Nilius, B.1    Owsianik, G.2
  • 8
    • 0030776196 scopus 로고    scopus 로고
    • OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans
    • Colbert HA, Smith TL, Bargmann CI. OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 1997; 17: 8259-69.
    • (1997) J Neurosci , vol.17 , pp. 8259-8269
    • Colbert, H.A.1    Smith, T.L.2    Bargmann, C.I.3
  • 14
    • 0038187752 scopus 로고    scopus 로고
    • Development of nociceptive synaptic inputs to the neonatal rat dorsal horn: Glutamate release by capsaicin and menthol
    • Baccei ML, Bardoni R, Fitzgerald M. Development of nociceptive synaptic inputs to the neonatal rat dorsal horn: Glutamate release by capsaicin and menthol. J Physiol 2003; 549: 231-42.
    • (2003) J Physiol , vol.549 , pp. 231-242
    • Baccei, M.L.1    Bardoni, R.2    Fitzgerald, M.3
  • 15
    • 34249717691 scopus 로고    scopus 로고
    • Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse
    • Sikand P, Premkumar LS. Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse. J Physiol 2007; 581: 631-47.
    • (2007) J Physiol , vol.581 , pp. 631-647
    • Sikand, P.1    Premkumar, L.S.2
  • 16
    • 70349272715 scopus 로고    scopus 로고
    • Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia
    • Jeffry JA, Yu SQ, Sikand P, Parihar A, Evans MS, Premkumar LS. Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia. PLoS One 2009; 4: e7021.
    • (2009) PLoS One , vol.4
    • Jeffry, J.A.1    Yu, S.Q.2    Sikand, P.3    Parihar, A.4    Evans, M.S.5    Premkumar, L.S.6
  • 17
    • 33646571242 scopus 로고    scopus 로고
    • Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
    • Cristino L, de Petrocellis L, Pryce G, Baker D, Guglielmotti V, Di Marzo V. Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain. Neurosci 2006; 139: 1405-15.
    • (2006) Neurosci , vol.139 , pp. 1405-1415
    • Cristino, L.1    de Petrocellis, L.2    Pryce, G.3    Baker, D.4    Guglielmotti, V.5    Di Marzo, V.6
  • 18
    • 0035940785 scopus 로고    scopus 로고
    • The distribution and regulation of vanilloid receptor VR1 and VR1 5' splice variant RNA expression in rat
    • Sanchez JF, Krause JE, Cortright DN. The distribution and regulation of vanilloid receptor VR1 and VR1 5' splice variant RNA expression in rat. Neurosci 2001; 107: 373-81.
    • (2001) Neurosci , vol.107 , pp. 373-381
    • Sanchez, J.F.1    Krause, J.E.2    Cortright, D.N.3
  • 20
    • 84892501824 scopus 로고    scopus 로고
    • Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius
    • Doyle MW, Bailey TW, Jin YH, Andresen MC. Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius. J Neurosci 2002; 129: 195-209
    • (2002) J Neurosci , vol.129 , pp. 195-209
    • Doyle, M.W.1    Bailey, T.W.2    Jin, Y.H.3    Andresen, M.C.4
  • 21
    • 0036713282 scopus 로고    scopus 로고
    • Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro
    • Marinelli S, Vaughan CW, Christie MJ, Connor M. Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. J Physiol 2002; 543: 531-40.
    • (2002) J Physiol , vol.543 , pp. 531-540
    • Marinelli, S.1    Vaughan, C.W.2    Christie, M.J.3    Connor, M.4
  • 22
    • 0037996964 scopus 로고    scopus 로고
    • Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors
    • Marinelli S, Di Marzo V, Berretta N, Matias I, Maccarrone M, Bernardi G, et al. Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors. J Neurosci 2003; 23: 3136-44.
    • (2003) J Neurosci , vol.23 , pp. 3136-3144
    • Marinelli, S.1    Di Marzo, V.2    Berretta, N.3    Matias, I.4    McCarrone, M.5    Bernardi, G.6
  • 23
    • 40249111593 scopus 로고    scopus 로고
    • TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons
    • Gibson HE, Edwards JG, Page RS, Van Hook MJ, Kauer JA. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 2008, 57: 746-59.
    • (2008) Neuron , vol.57 , pp. 746-759
    • Gibson, H.E.1    Edwards, J.G.2    Page, R.S.3    Van Hook, M.J.4    Kauer, J.A.5
  • 24
    • 78649374688 scopus 로고    scopus 로고
    • TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
    • Chávez AE, Chiu CQ, Castillo PE. TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus. Nat Neurosci 2010; 13: 1511-8.
    • (2010) Nat Neurosci , vol.13 , pp. 1511-1518
    • Chávez, A.E.1    Chiu, C.Q.2    Castillo, P.E.3
  • 25
    • 78649369301 scopus 로고    scopus 로고
    • Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens
    • Grueter BA, Brasnjo G, Malenka RC. Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens. Nat Neurosci 2010; 13: 1519-25.
    • (2010) Nat Neurosci , vol.13 , pp. 1519-1525
    • Grueter, B.A.1    Brasnjo, G.2    Malenka, R.C.3
  • 26
    • 79955732207 scopus 로고    scopus 로고
    • Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells
    • Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, et al. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci 2011; 31: 5067-77.
    • (2011) J Neurosci , vol.31 , pp. 5067-5077
    • Cavanaugh, D.J.1    Chesler, A.T.2    Jackson, A.C.3    Sigal, Y.M.4    Yamanaka, H.5    Grant, R.6
  • 28
    • 0032561203 scopus 로고    scopus 로고
    • Capsaicin facilitates excitatory but not inhibitory synaptic transmission in substantia gelatinosa of the rat spinal cord
    • Yang K, Kumamoto E, Furue H, Yoshimura M. Capsaicin facilitates excitatory but not inhibitory synaptic transmission in substantia gelatinosa of the rat spinal cord. Neurosci Lett 1998; 255: 135-8.
    • (1998) Neurosci Lett , vol.255 , pp. 135-138
    • Yang, K.1    Kumamoto, E.2    Furue, H.3    Yoshimura, M.4
  • 29
    • 34047266824 scopus 로고    scopus 로고
    • Vanilloid receptor-1 (TRPV1)-dependent activation of inhibitory neurotransmission in spinal substantia gelatinosa neurons of mouse
    • Ferrini F, Salio C, Vergnano AM, Merighi A. Vanilloid receptor-1 (TRPV1)-dependent activation of inhibitory neurotransmission in spinal substantia gelatinosa neurons of mouse. Pain 2007; 129: 195-209.
    • (2007) Pain , vol.129 , pp. 195-209
    • Ferrini, F.1    Salio, C.2    Vergnano, A.M.3    Merighi, A.4
  • 30
    • 70349952436 scopus 로고    scopus 로고
    • TRPV1 expression and activity during retinoic acid-induced neuronal differentiation
    • El Andaloussi-Lilja J, Lundqvist J, Forsby A. TRPV1 expression and activity during retinoic acid-induced neuronal differentiation. Neurochem Int 2009; 55: 768-74.
    • (2009) Neurochem Int , vol.55 , pp. 768-774
    • El Andaloussi-Lilja, J.1    Lundqvist, J.2    Forsby, A.3
  • 31
    • 59449102850 scopus 로고    scopus 로고
    • TRPV1: Contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure
    • Sappington RM, Sidorova T, Long DJ, Calkins DJ. TRPV1: Contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest Ophthalmol Vis Sci 2009; 50: 717-28.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 717-728
    • Sappington, R.M.1    Sidorova, T.2    Long, D.J.3    Calkins, D.J.4
  • 32
    • 0038751852 scopus 로고    scopus 로고
    • Versatile regulation of cytosolic Ca2+ by vanilloid receptor-1 in rat dorsal root ganglion neurons
    • Liu M, Liu MC, Magoulas C, Priestley JAV, Willmott NJ. Versatile regulation of cytosolic Ca2+ by vanilloid receptor-1 in rat dorsal root ganglion neurons. J Biol Chem 2003; 278: 5462-72.
    • (2003) J Biol Chem , vol.278 , pp. 5462-5472
    • Liu, M.1    Liu, M.C.2    Magoulas, C.3    Priestley, J.A.V.4    Willmott, N.J.5
  • 33
    • 0037272795 scopus 로고    scopus 로고
    • Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-triphosphate-sensitive stores
    • Marshall ICB, Owen DE, Cripps TV, Davis JB, McNulty S, Smart D. Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-triphosphate-sensitive stores. Br J Pharmacol 2003; 138: 172-6.
    • (2003) Br J Pharmacol , vol.138 , pp. 172-176
    • Marshall, I.C.B.1    Owen, D.E.2    Cripps, T.V.3    Davis, J.B.4    McNulty, S.5    Smart, D.6
  • 34
    • 1242292301 scopus 로고    scopus 로고
    • The vanilloid receptor-1 is expressed in rat spinal dorsal horn astrocytes
    • Doly S, Fischer J, Salio C, Conrath M. The vanilloid receptor-1 is expressed in rat spinal dorsal horn astrocytes. Neurosci Lett 2004; 357: 123-6.
    • (2004) Neurosci Lett , vol.357 , pp. 123-126
    • Doly, S.1    Fischer, J.2    Salio, C.3    Conrath, M.4
  • 35
    • 48249116728 scopus 로고    scopus 로고
    • Contribution of TRPV1 to microgliaderived IL-6 and NFkappaB translocation with elevated hydrostatic pressure
    • Sappington RM, Calkins DJ. Contribution of TRPV1 to microgliaderived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest Ophthalmol Vis Sci 2008; 49: 3004-17.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 3004-3017
    • Sappington, R.M.1    Calkins, D.J.2
  • 36
    • 33749376486 scopus 로고    scopus 로고
    • Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels
    • Cuypers E, Yanagihara A, Karlsson E, Tytgat J. Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett 2006; 580: 5728-32.
    • (2006) FEBS Lett , vol.580 , pp. 5728-5732
    • Cuypers, E.1    Yanagihara, A.2    Karlsson, E.3    Tytgat, J.4
  • 37
    • 33750873334 scopus 로고    scopus 로고
    • Spider toxins activate the capsaicin receptor to produce inflammatory pain
    • Siemens J, Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, et al. Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature 2006; 444: 208-12.
    • (2006) Nature , vol.444 , pp. 208-212
    • Siemens, J.1    Siemens, J.2    Zhou, S.3    Piskorowski, R.4    Nikai, T.5    Lumpkin, E.A.6
  • 38
    • 77953271751 scopus 로고    scopus 로고
    • A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain
    • Bohlen CJ, Priel A, Zhou S, King D, Siemens J, Julius D. A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell 2010; 141: 834-45.
    • (2010) Cell , vol.141 , pp. 834-845
    • Bohlen, C.J.1    Priel, A.2    Zhou, S.3    King, D.4    Siemens, J.5    Julius, D.6
  • 40
    • 0035918311 scopus 로고    scopus 로고
    • The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism
    • De Petrocellis L, Bisogno T, Maccarrone M, Davis JB, Finazzi-Agrò A, Di Marzo V. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J Biol Chem 2001; 276: 12856-63.
    • (2001) J Biol Chem , vol.276 , pp. 12856-12863
    • De Petrocellis, L.1    Bisogno, T.2    McCarrone, M.3    Davis, J.B.4    Finazzi-Agrò, A.5    Di Marzo, V.6
  • 41
  • 42
  • 43
    • 4744350135 scopus 로고    scopus 로고
    • Actions of two naturally occurring saturated Nacyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels
    • De Petrocellis L, Chu CJ, Schiano MA, Kellner JC, Walker JM, Di Marzo V. Actions of two naturally occurring saturated Nacyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br J Pharmacol 2004; 143: 251-6.
    • (2004) Br J Pharmacol , vol.143 , pp. 251-256
    • De Petrocellis, L.1    Chu, C.J.2    Schiano, M.A.3    Kellner, J.C.4    Walker, J.M.5    Di Marzo, V.6
  • 44
    • 0042734414 scopus 로고    scopus 로고
    • Activation of TRPV1 by the satiety factor oleoylethanolamide
    • Ahern GP. Activation of TRPV1 by the satiety factor oleoylethanolamide. J Biol Chem 2003; 278: 30429-34.
    • (2003) J Biol Chem , vol.278 , pp. 30429-30434
    • Ahern, G.P.1
  • 45
    • 84874400499 scopus 로고    scopus 로고
    • Activation and desensitization of TRPV1 channels in sensory neurons by the PPAR_ agonist palmitoylethanolamide
    • Ambrosino P, Soldovieri MV, Russo C, Taglialatela M. Activation and desensitization of TRPV1 channels in sensory neurons by the PPAR_ agonist palmitoylethanolamide. Br J Pharmacol 2013; 168: 1430-44.
    • (2013) Br J Pharmacol , vol.168 , pp. 1430-1444
    • Ambrosino, P.1    Soldovieri, M.V.2    Russo, C.3    Taglialatela, M.4
  • 46
    • 0004906771 scopus 로고    scopus 로고
    • Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
    • Hwang SW, Cho H, Kwak J, Lee SY, Kang CJ, Jung J, et al. Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances. Proc Natl Acad Sci USA 2000; 97: 6155-60.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6155-6160
    • Hwang, S.W.1    Cho, H.2    Kwak, J.3    Lee, S.Y.4    Kang, C.J.5    Jung, J.6
  • 47
    • 84859984051 scopus 로고    scopus 로고
    • 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel
    • Wen H, Östman J, Bubb KJ, Panayiotou C, Priestley JV, Baker MD, et al. 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem 2012; 287: 13868-76.
    • (2012) J Biol Chem , vol.287 , pp. 13868-13876
    • Wen, H.1    Östman, J.2    Bubb, K.J.3    Panayiotou, C.4    Priestley, J.V.5    Baker, M.D.6
  • 48
    • 84870505112 scopus 로고    scopus 로고
    • A re-evaluation of 9-HODE activity at TRPV1 channels in comparison to anandamide: Enantioselectivity and effects at other TRP channels and in sensory neurons
    • De Petrocellis L, Schiano Moriello A, Imperatore R, Cristino L, Starowicz K, Di Marzo V. A re-evaluation of 9-HODE activity at TRPV1 channels in comparison to anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons. Br J Pharmacol 2012; 167: 1643-51.
    • (2012) Br J Pharmacol , vol.167 , pp. 1643-1651
    • De Petrocellis, L.1    Schiano, M.A.2    Imperatore, R.3    Cristino, L.4    Starowicz, K.5    Di Marzo, V.6
  • 49
    • 84875724383 scopus 로고    scopus 로고
    • Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism
    • Starowicz K, Makuch W, Korostynski M, Malek N, Slezak M, Zychowska M, et al. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. PLoS One 2013; 8: e60040.
    • (2013) PLoS One , vol.8
    • Starowicz, K.1    Makuch, W.2    Korostynski, M.3    Malek, N.4    Slezak, M.5    Zychowska, M.6
  • 50
    • 33646845297 scopus 로고    scopus 로고
    • Polyamines are potent ligands for the capsaicin receptor TRPV1
    • Ahern GP, Wang X, Miyares RL. Polyamines are potent ligands for the capsaicin receptor TRPV1. J Biol Chem 2006; 281: 8991-5.
    • (2006) J Biol Chem , vol.281 , pp. 8991-8995
    • Ahern, G.P.1    Wang, X.2    Miyares, R.L.3
  • 54
    • 23044515008 scopus 로고    scopus 로고
    • Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels
    • De Petrocellis L, Di Marzo V. Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels. Life Sci 2005; 77: 1651-66.
    • (2005) Life Sci , vol.77 , pp. 1651-1666
    • De Petrocellis, L.1    Di Marzo, V.2
  • 55
    • 37249040918 scopus 로고    scopus 로고
    • Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways
    • Starowicz K, Maione S, Cristino L, Palazzo E, Marabese I, Rossi F, et al. Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways. J Neurosci 2007; 27: 13739-49.
    • (2007) J Neurosci , vol.27 , pp. 13739-13749
    • Starowicz, K.1    Maione, S.2    Cristino, L.3    Palazzo, E.4    Marabese, I.5    Rossi, F.6
  • 56
    • 29244484493 scopus 로고    scopus 로고
    • NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    • Zhang X, Huang J, McNaughton PA. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J 2005; 24: 4211-23.
    • (2005) EMBO J , vol.24 , pp. 4211-4223
    • Zhang, X.1    Huang, J.2    McNaughton, P.A.3
  • 57
    • 0034700494 scopus 로고    scopus 로고
    • Induction of vanilloid receptor channel activity by protein kinase C
    • Premkumar LS, Ahern GP. Induction of vanilloid receptor channel activity by protein kinase C. Nature 2000; 408: 985-90.
    • (2000) Nature , vol.408 , pp. 985-990
    • Premkumar, L.S.1    Ahern, G.P.2
  • 58
    • 0035927651 scopus 로고    scopus 로고
    • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    • Chuang H-H, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 2001; 411: 957-62.
    • (2001) Nature , vol.411 , pp. 957-962
    • Chuang, H.-H.1    Prescott, E.D.2    Kong, H.3    Shields, S.4    Jordt, S.E.5    Basbaum, A.I.6
  • 59
    • 0346118925 scopus 로고    scopus 로고
    • Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway
    • Mohapatra DP, Nau C. Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J Biol Chem 2003; 278: 50080-90.
    • (2003) J Biol Chem , vol.278 , pp. 50080-50090
    • Mohapatra, D.P.1    Nau, C.2
  • 60
    • 77952237425 scopus 로고    scopus 로고
    • Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    • Xu ZZ, Zhang L, Liu T, Park JY, Berta T, Yang R, et al. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med 2010; 16: 592-7.
    • (2010) Nat Med , vol.16 , pp. 592-597
    • Xu, Z.Z.1    Zhang, L.2    Liu, T.3    Park, J.Y.4    Berta, T.5    Yang, R.6
  • 61
    • 83455177641 scopus 로고    scopus 로고
    • Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: Distinct roles of resolvin D1, D2, and E1
    • Park CK, Xu ZZ, Liu T, Lü N, Serhan CN, Ji RR. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: Distinct roles of resolvin D1, D2, and E1. J Neurosci 2011; 31: 18433-8.
    • (2011) J Neurosci , vol.31 , pp. 18433-18438
    • Park, C.K.1    Xu, Z.Z.2    Liu, T.3    Lü, N.4    Serhan, C.N.5    Ji, R.R.6
  • 62
    • 53749084409 scopus 로고    scopus 로고
    • Phospholipase C mediated modulation of TRPV1 channels
    • Rohacs T, Thyagarajan B, Lukacs V. Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol 2008; 37: 153-63.
    • (2008) Mol Neurobiol , vol.37 , pp. 153-163
    • Rohacs, T.1    Thyagarajan, B.2    Lukacs, V.3
  • 63
    • 33750524257 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase binds to TRPV1 and mediates NGFstimulated TRPV1 trafficking to the plasma membrane
    • Stein AT, Ufret-Vincenty CA, Hua L, Santana LF, Gordon SE. Phosphoinositide 3-kinase binds to TRPV1 and mediates NGFstimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol 2006; 128: 509-22.
    • (2006) J Gen Physiol , vol.128 , pp. 509-522
    • Stein, A.T.1    Ufret-Vincenty, C.A.2    Hua, L.3    Santana, L.F.4    Gordon, S.E.5
  • 64
    • 1342346561 scopus 로고    scopus 로고
    • Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding
    • Jung J, Shin JS, Lee SY, Hwang SW, Koo J, Cho H, et al. Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem 2004; 279: 7048-54.
    • (2004) J Biol Chem , vol.279 , pp. 7048-7054
    • Jung, J.1    Shin, J.S.2    Lee, S.Y.3    Hwang, S.W.4    Koo, J.5    Cho, H.6
  • 65
    • 0037104657 scopus 로고    scopus 로고
    • cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
    • Bhave G, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 2002; 35: 721-31.
    • (2002) Neuron , vol.35 , pp. 721-731
    • Bhave, G.1    Zhu, W.2    Wang, H.3    Brasier, D.J.4    Oxford, G.S.5    Gereau, R.W.6
  • 66
    • 17144397173 scopus 로고    scopus 로고
    • Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMPdependent protein kinase
    • Mohapatra DP, Nau C. Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMPdependent protein kinase. J Biol Chem 2005; 280: 13424-32.
    • (2005) J Biol Chem , vol.280 , pp. 13424-13432
    • Mohapatra, D.P.1    Nau, C.2
  • 67
    • 0030956114 scopus 로고    scopus 로고
    • The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons
    • Koplas PA, Rosenberg RL, Oxford GS. The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci 1997; 17: 3525-37.
    • (1997) J Neurosci , vol.17 , pp. 3525-3537
    • Koplas, P.A.1    Rosenberg, R.L.2    Oxford, G.S.3
  • 68
    • 84861732941 scopus 로고    scopus 로고
    • Agonist-and Ca2+-dependent desensitization of TRPV1 targets the receptor to lysosomes for degradation
    • Sanz-Salvador L, Andres-Borderia A, Ferrer-Montiel A, Planells-Cases R. Agonist-and Ca2+-dependent desensitization of TRPV1 targets the receptor to lysosomes for degradation. J Biol Chem 2012; 287: 19462-71.
    • (2012) J Biol Chem , vol.287 , pp. 19462-19471
    • Sanz-Salvador, L.1    Andres-Borderia, A.2    Ferrer-Montiel, A.3    Planells-Cases, R.4
  • 69
    • 37249088295 scopus 로고    scopus 로고
    • Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I
    • Zhu W, Xu P, Cuascut FX, Hall AK, Oxford GS. Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. J Neurosci 2007; 27: 13770-80.
    • (2007) J Neurosci , vol.27 , pp. 13770-13780
    • Zhu, W.1    Xu, P.2    Cuascut, F.X.3    Hall, A.K.4    Oxford, G.S.5
  • 70
    • 0035810934 scopus 로고    scopus 로고
    • Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
    • Tominaga M, Wada M, Masu M. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci USA 2001; 98: 6951-6.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6951-6956
    • Tominaga, M.1    Wada, M.2    Masu, M.3
  • 71
    • 0034668893 scopus 로고    scopus 로고
    • Intracellular ATP increases capsaicin-activated channel activity by interacting with nucleotide-binding domains
    • Kwak J, Wang MH, Hwang SW, Kim TY, Lee SY, Oh U. Intracellular ATP increases capsaicin-activated channel activity by interacting with nucleotide-binding domains. J Neurosci 2000; 20: 8298-304.
    • (2000) J Neurosci , vol.20 , pp. 8298-8304
    • Kwak, J.1    Wang, M.H.2    Hwang, S.W.3    Kim, T.Y.4    Lee, S.Y.5    Oh, U.6
  • 72
    • 84879845514 scopus 로고    scopus 로고
    • The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1)
    • Morales-Lázaro SL, Simon, SA, Rosenbaum T. The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1). J Physiol 2013; 591: 3109-21.
    • (2013) J Physiol , vol.591 , pp. 3109-3121
    • Morales-Lázaro, S.L.1    Simon, S.A.2    Rosenbaum, T.3
  • 73
    • 67349199664 scopus 로고    scopus 로고
    • Excitation and sensitization of nociceptors by bradykinin: What do we know?
    • Mizumura K, Sugiura T, Katanosaka K, Banik RK, Kozaki Y. Excitation and sensitization of nociceptors by bradykinin: What do we know? Exp Brain Res 2009; 196: 53-65.
    • (2009) Exp Brain Res , vol.196 , pp. 53-65
    • Mizumura, K.1    Sugiura, T.2    Katanosaka, K.3    Banik, R.K.4    Kozaki, Y.5
  • 74
    • 84880435653 scopus 로고    scopus 로고
    • Distinctive Changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons
    • Lukacs V, Yudin Y, Hammond GR, Sharma E, Fukami K, Rohacs T. Distinctive Changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons. J Neurosci 2013; 33: 11451-63.
    • (2013) J Neurosci , vol.33 , pp. 11451-11463
    • Lukacs, V.1    Yudin, Y.2    Hammond, G.R.3    Sharma, E.4    Fukami, K.5    Rohacs, T.6
  • 75
    • 2342466078 scopus 로고    scopus 로고
    • Histamine-induced Ca2+ influx via the PLA2/lipoxygenase/TRPV1 pathway in rat sensory neurons
    • Kim BM, Lee SH, Shim WS, Oh U. Histamine-induced Ca2+ influx via the PLA2/lipoxygenase/TRPV1 pathway in rat sensory neurons. Neurosci Lett 2004; 361: 159-62.
    • (2004) Neurosci Lett , vol.361 , pp. 159-162
    • Kim, B.M.1    Lee, S.H.2    Shim, W.S.3    Oh, U.4
  • 76
    • 7444235361 scopus 로고    scopus 로고
    • TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation
    • Sugiuar T, Bielefeldt K, Gebhart GF. TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. J Neurosci 2004; 24: 9521-30.
    • (2004) J Neurosci , vol.24 , pp. 9521-9530
    • Sugiuar, T.1    Bielefeldt, K.2    Gebhart, G.F.3
  • 78
    • 0032849082 scopus 로고    scopus 로고
    • Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin
    • Shu X, Mendell LM. Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. Neurosci Lett 1999; 274: 159-62.
    • (1999) Neurosci Lett , vol.274 , pp. 159-162
    • Shu, X.1    Mendell, L.M.2
  • 79
    • 33947672465 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1
    • Zhu W, Oxford GS. Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol Cell Neurosci 2007; 34: 689-700.
    • (2007) Mol Cell Neurosci , vol.34 , pp. 689-700
    • Zhu, W.1    Oxford, G.S.2
  • 80
    • 2342604388 scopus 로고    scopus 로고
    • Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia
    • Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, et al. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci 2004; 24: 4300-12.
    • (2004) J Neurosci , vol.24 , pp. 4300-4312
    • Amadesi, S.1    Nie, J.2    Vergnolle, N.3    Cottrell, G.S.4    Grady, E.F.5    Trevisani, M.6
  • 81
    • 2442468123 scopus 로고    scopus 로고
    • Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain
    • Dai Y, Moriyama T, Higashi T, Togashi K, Kobayashi K, Yamanaka H, et al. Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci 2004; 24: 4293-99.
    • (2004) J Neurosci , vol.24 , pp. 4293-4299
    • Dai, Y.1    Moriyama, T.2    Higashi, T.3    Togashi, K.4    Kobayashi, K.5    Yamanaka, H.6
  • 82
    • 2942614748 scopus 로고    scopus 로고
    • Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity
    • Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A. Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J Biol Chem 2004; 279: 25665-72.
    • (2004) J Biol Chem , vol.279 , pp. 25665-25672
    • Morenilla-Palao, C.1    Planells-Cases, R.2    García-Sanz, N.3    Ferrer-Montiel, A.4
  • 83
    • 0028970004 scopus 로고
    • Cyclic AMP mediates the prostaglandin E2-induced potentiation of bradykinin excitation in rat sensory neurons
    • Cui M, Nicol GD. Cyclic AMP mediates the prostaglandin E2-induced potentiation of bradykinin excitation in rat sensory neurons. Neurosci 1995; 66: 459-66.
    • (1995) Neurosci , vol.66 , pp. 459-466
    • Cui, M.1    Nicol, G.D.2
  • 84
    • 0034977496 scopus 로고    scopus 로고
    • The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase
    • De Petrocellis L, Harrison S, Bisogno T, Tognetto M, Brandi I, Smith GD, et al. The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase. J Neurochem 2001; 77: 1660-3.
    • (2001) J Neurochem , vol.77 , pp. 1660-1663
    • De Petrocellis, L.1    Harrison, S.2    Bisogno, T.3    Tognetto, M.4    Brandi, I.5    Smith, G.D.6
  • 86
    • 24744469860 scopus 로고    scopus 로고
    • Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolasedependent arachidonic acid conjugation in the nervous system
    • Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, et al. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolasedependent arachidonic acid conjugation in the nervous system. J Biol Chem 2005; 280: 31405-12.
    • (2005) J Biol Chem , vol.280 , pp. 31405-31412
    • Högestätt, E.D.1    Jönsson, B.A.2    Ermund, A.3    Andersson, D.A.4    Björk, H.5    Alexander, J.P.6
  • 87
    • 0034644842 scopus 로고    scopus 로고
    • Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity
    • De Petrocellis L, Bisogno T, Davis JB, Pertwee RG, Di Marzo V. Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett 2000; 483: 52-6.
    • (2000) FEBS Lett , vol.483 , pp. 52-56
    • De Petrocellis, L.1    Bisogno, T.2    Davis, J.B.3    Pertwee, R.G.4    Di Marzo, V.5
  • 88
    • 33846636000 scopus 로고    scopus 로고
    • Reduced anxiety, conditioned fear, and hippocampal longterm potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice
    • Marsch R, Foeller E, Rammes G, Bunck M, Kössl M, Holsboer F, et al. Reduced anxiety, conditioned fear, and hippocampal longterm potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J Neurosci 2007; 27: 832-9.
    • (2007) J Neurosci , vol.27 , pp. 832-839
    • Marsch, R.1    Foeller, E.2    Rammes, G.3    Bunck, M.4    Kössl, M.5    Holsboer, F.6
  • 89
    • 84980052949 scopus 로고    scopus 로고
    • TRPV1: A stress response protein in the central nervous system
    • Ho KW, Ward NJ, Calkins DJ. TRPV1: A stress response protein in the central nervous system. Am J Neurodegener Dis 2012; 1: 1-14.
    • (2012) Am J Neurodegener Dis , vol.1 , pp. 1-14
    • Ho, K.W.1    Ward, N.J.2    Calkins, D.J.3
  • 90
    • 15944389904 scopus 로고    scopus 로고
    • Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils
    • Pegorini S, Braida D, Verzoni C, Guerini-Rocco C, Consalez GG, Croci L, et al. Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils. Br J Pharmacol 2005; 144: 727-35.
    • (2005) Br J Pharmacol , vol.144 , pp. 727-735
    • Pegorini, S.1    Braida, D.2    Verzoni, C.3    Guerini-Rocco, C.4    Consalez, G.G.5    Croci, L.6
  • 91
    • 0037704448 scopus 로고    scopus 로고
    • Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: Role of vanilloid receptors and lipoxygenases
    • Veldhuis WB, van der Stelt M, Wadman MW, van Zadelhoff G, Maccarrone M, Fezza F, et al. Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: Role of vanilloid receptors and lipoxygenases. J Neurosci 2003; 23: 4127-33.
    • (2003) J Neurosci , vol.23 , pp. 4127-4133
    • Veldhuis, W.B.1    van der Stelt, M.2    Wadman, M.W.3    van Zadelhoff, G.4    McCarrone, M.5    Fezza, F.6
  • 92
    • 0037341020 scopus 로고    scopus 로고
    • Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease
    • Lastres-Becker I, de Miguel R, De Petrocellis L, Makriyannis A, Di Marzo V, Fernández-Ruiz J. Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease. J Neurochem 2003; 84: 1097-109.
    • (2003) J Neurochem , vol.84 , pp. 1097-1109
    • Lastres-Becker, I.1    de Miguel, R.2    De Petrocellis, L.3    Makriyannis, A.4    Di Marzo, V.5    Fernández-Ruiz, J.6
  • 95
    • 84859885582 scopus 로고    scopus 로고
    • TRPV1 antagonists: Clinical setbacks and prospects for future development
    • Kort ME, Kym PR. TRPV1 antagonists: Clinical setbacks and prospects for future development. Prog Med Chem 2012; 51: 57-70.
    • (2012) Prog Med Chem , vol.51 , pp. 57-70
    • Kort, M.E.1    Kym, P.R.2
  • 96
    • 33748680717 scopus 로고    scopus 로고
    • TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists
    • Cui M, Honore P, Zhong C, Gauvin D, Mikusa J, Hernandez G, et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J Neurosci 2006; 26: 9385-93.
    • (2006) J Neurosci , vol.26 , pp. 9385-9393
    • Cui, M.1    Honore, P.2    Zhong, C.3    Gauvin, D.4    Mikusa, J.5    Hernandez, G.6
  • 97
    • 84874645499 scopus 로고    scopus 로고
    • TRP channels and analgesia
    • Premkumar LS, Abooj M. TRP channels and analgesia. Life Sci 2013; 92: 415-24
    • (2013) Life Sci , vol.92 , pp. 415-424
    • Premkumar, L.S.1    Abooj, M.2
  • 99
    • 68149094343 scopus 로고    scopus 로고
    • NGX-4010, a highconcentration capsaicin dermal patch for lasting relief of peripheral neuropathic pain
    • Noto C, Pappagallo M, Szallasi A. NGX-4010, a highconcentration capsaicin dermal patch for lasting relief of peripheral neuropathic pain. Curr Opin Investig Drugs 2009; 10: 702-10.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 702-710
    • Noto, C.1    Pappagallo, M.2    Szallasi, A.3
  • 100
    • 84892516644 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT00875537 (Accessed on: November 25, 2013).
  • 101
    • 84892536108 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT01886313 (Accessed on: November 25, 2013).
  • 102
    • 84892517438 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT01341548 (Accessed on: November 25, 2013).
  • 103
    • 84892550325 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT01762228 (Accessed on: November 25, 2013).
  • 104
    • 84892507998 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT01777672 (Accessed on: November 25, 2013).
  • 105
    • 84892519401 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT00804154 (Accessed on: November 25, 2013).
  • 108
    • 80052216483 scopus 로고    scopus 로고
    • The vanilloid agonist resiniferatoxin for interventional-based pain control
    • Iadarola MJ, Mannes AJ. The vanilloid agonist resiniferatoxin for interventional-based pain control. Curr Top Med Chem 2011; 11: 2171-9.
    • (2011) Curr Top Med Chem , vol.11 , pp. 2171-2179
    • Iadarola, M.J.1    Mannes, A.J.2
  • 110
    • 0346221274 scopus 로고    scopus 로고
    • [3H] Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 protein distribution
    • Roberts JC, Davis JB, Benham CD. [3H] Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 protein distribution. Brain Res 2004; 995: 176-83.
    • (2004) Brain Res , vol.995 , pp. 176-183
    • Roberts, J.C.1    Davis, J.B.2    Benham, C.D.3
  • 112
    • 0037581663 scopus 로고    scopus 로고
    • Capsaicin binds to the intracellular domain of the capsaicinactivated ion channel
    • Jung J, Hwang SW, Kwak J, Lee SY, Kang CJ, Kim WB, et al. Capsaicin binds to the intracellular domain of the capsaicinactivated ion channel. J Neurosci 1999; 19: 529-38.
    • (1999) J Neurosci , vol.19 , pp. 529-538
    • Jung, J.1    Hwang, S.W.2    Kwak, J.3    Lee, S.Y.4    Kang, C.J.5    Kim, W.B.6
  • 113
    • 0037113918 scopus 로고    scopus 로고
    • Agonist recognition sites in the cytosolic tails of vanilloid receptor 1
    • Jung J, Lee SY, Hwang SW, Cho H, Shin J, Kang YS, et al. Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J Biol Chem 2002; 277: 44448-54.
    • (2002) J Biol Chem , vol.277 , pp. 44448-44454
    • Jung, J.1    Lee, S.Y.2    Hwang, S.W.3    Cho, H.4    Shin, J.5    Kang, Y.S.6
  • 114
    • 79951810885 scopus 로고    scopus 로고
    • N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity
    • De Petrocellis L, Guida F, Schiano Moriello A, De Chiaro M, Piscitelli F, de Novellis V, et al. N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. Pharmacol Res 2011; 63: 294-9.
    • (2011) Pharmacol Res , vol.63 , pp. 294-299
    • De Petrocellis, L.1    Guida, F.2    Schiano, M.A.3    De Chiaro, M.4    Piscitelli, F.5    de Novellis, V.6
  • 117
    • 34948819283 scopus 로고    scopus 로고
    • Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
    • Binshtok AM, Bean BP, Woolf CJ. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 2007; 449: 607-10.
    • (2007) Nature , vol.449 , pp. 607-610
    • Binshtok, A.M.1    Bean, B.P.2    Woolf, C.J.3
  • 118
    • 33750968787 scopus 로고    scopus 로고
    • Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation
    • Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R. Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Sci 2006; 314: 1004-7.
    • (2006) Sci , vol.314 , pp. 1004-1007
    • Valiyaveetil, F.I.1    Leonetti, M.2    Muir, T.W.3    McKinnon, R.4
  • 122
    • 77955802570 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid-1 antagonists: A survey of recent patent literature
    • Voight EA, Kort ME. Transient receptor potential vanilloid-1 antagonists: A survey of recent patent literature. Expert Opin Ther Pat 2010; 20: 1107-22.
    • (2010) Expert Opin Ther Pat , vol.20 , pp. 1107-1122
    • Voight, E.A.1    Kort, M.E.2
  • 123
    • 84877860799 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid 1 as a therapeutic target in analgesia
    • Szolcsányi J, Pintér E. Transient receptor potential vanilloid 1 as a therapeutic target in analgesia. Expert Opin Ther Targets 2013; 17: 641-57.
    • (2013) Expert Opin Ther Targets , vol.17 , pp. 641-657
    • Szolcsányi, J.1    Pintér, E.2
  • 124
    • 41749117999 scopus 로고    scopus 로고
    • Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
    • Gavva NR, Treanor JJ, Garami A, Fang L, Surapaneni S, Akrami A, et al. Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 2008; 136: 202-10.
    • (2008) Pain , vol.136 , pp. 202-210
    • Gavva, N.R.1    Treanor, J.J.2    Garami, A.3    Fang, L.4    Surapaneni, S.5    Akrami, A.6
  • 126
    • 23944483778 scopus 로고    scopus 로고
    • 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro
    • Shimizu I, Iida T, Horiuchi N, Caterina MJ. 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro. J Pharmacol Exp Ther 2005; 314: 1378-85.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1378-1385
    • Shimizu, I.1    Iida, T.2    Horiuchi, N.3    Caterina, M.J.4
  • 127
    • 60049089359 scopus 로고    scopus 로고
    • Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia
    • Honore P, Chandran P, Hernandez G, Gauvin DM, Mikusa JP, Zhong C, et al. Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. Pain 2009; 142: 27-35.
    • (2009) Pain , vol.142 , pp. 27-35
    • Honore, P.1    Chandran, P.2    Hernandez, G.3    Gauvin, D.M.4    Mikusa, J.P.5    Zhong, C.6
  • 128
    • 79551509771 scopus 로고    scopus 로고
    • Thermoregulatory phenotype of the Trpv1 knockout mouse: Thermoeffector dysbalance with hyperkinesis
    • Garami A, Pakai E, Oliveira DL, Steiner AA, Wanner SP, Almeida MC, et al. Thermoregulatory phenotype of the Trpv1 knockout mouse: Thermoeffector dysbalance with hyperkinesis. J Neurosci 2011; 31: 1721-33.
    • (2011) J Neurosci , vol.31 , pp. 1721-1733
    • Garami, A.1    Pakai, E.2    Oliveira, D.L.3    Steiner, A.A.4    Wanner, S.P.5    Almeida, M.C.6
  • 129
    • 84864142720 scopus 로고    scopus 로고
    • 7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1Hpyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity
    • Nash MS, McIntyre P, Groarke A, Lilley E, Culshaw A, Hallett A, et al. 7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1Hpyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity. J Pharmacol Exp Ther 2012; 342: 389-98.
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 389-398
    • Nash, M.S.1    McIntyre, P.2    Groarke, A.3    Lilley, E.4    Culshaw, A.5    Hallett, A.6
  • 130
    • 84864147863 scopus 로고    scopus 로고
    • Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature
    • Reilly RM, McDonald HA, Puttfarcken PS, Joshi SK, Lewis L, Pai M, et al. Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature. J Pharmacol Exp Ther 2012; 342: 416-28.
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 416-428
    • Reilly, R.M.1    McDonald, H.A.2    Puttfarcken, P.S.3    Joshi, S.K.4    Lewis, L.5    Pai, M.6
  • 131
    • 58149107126 scopus 로고    scopus 로고
    • Clinical development of TRPV1 antagonists: Targeting a pivotal point in the pain pathway
    • Gunthorpe MJ, Chizh BA. Clinical development of TRPV1 antagonists: Targeting a pivotal point in the pain pathway. Drug Discov Today 2009; 14: 56-67.
    • (2009) Drug Discov Today , vol.14 , pp. 56-67
    • Gunthorpe, M.J.1    Chizh, B.A.2
  • 132
    • 84865336959 scopus 로고    scopus 로고
    • Targeting TRPV1 for pain relief: Limits, losers and laurels
    • Szallasi A, Sheta M. Targeting TRPV1 for pain relief: limits, losers and laurels. Expert Opin Investig Drugs 2012; 21: 1351-69.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 1351-1369
    • Szallasi, A.1    Sheta, M.2
  • 134
    • 33646677987 scopus 로고    scopus 로고
    • Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development
    • Rami HK, Thompson M, Stemp G, Fell S, Jerman JC, Stevens AJ, et al. Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett 2006; 16: 3287-91.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 3287-3291
    • Rami, H.K.1    Thompson, M.2    Stemp, G.3    Fell, S.4    Jerman, J.C.5    Stevens, A.J.6
  • 135
    • 34848820269 scopus 로고    scopus 로고
    • The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans
    • Chizh BA, O'Donnell MB, Napolitano A, Wang J, Brooke AC, Aylott MC, et al. The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans. Pain 2007; 132: 132-41.
    • (2007) Pain , vol.132 , pp. 132-141
    • Chizh, B.A.1    O'Donnell, M.B.2    Napolitano, A.3    Wang, J.4    Brooke, A.C.5    Aylott, M.C.6
  • 137
    • 84892534870 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT0269022 (Accessed on: November 25, 2013).
  • 138
    • 84892546390 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT0281684 (Accessed on: November 25, 2013).
  • 139
    • 84892550027 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT00461682 (Accessed on: November 25, 2013).
  • 140
    • 84892499522 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT01424514 (Accessed on: November 25, 2013).
  • 147
    • 23044473189 scopus 로고    scopus 로고
    • A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid
    • El Kouhen R, Surowy CS, Bianchi BR, Neelands TR, McDonald HA, Niforatos W, et al. A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid. J Pharmacol Exp Ther 2005; 314: 400-9.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 400-409
    • El Kouhen, R.1    Surowy, C.S.2    Bianchi, B.R.3    Neelands, T.R.4    McDonald, H.A.5    Niforatos, W.6
  • 148
  • 150
    • 45749092572 scopus 로고    scopus 로고
    • Antihyperalgesic effects of (R, E)-N-(2-hydroxy-2,3-dihydro-1H inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats
    • Lehto SG, Tamir R, Deng H, Klionsky L, Kuang R, Le A, et al. Antihyperalgesic effects of (R, E)-N-(2-hydroxy-2,3-dihydro-1H inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther 2008; 326: 218-29.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 218-229
    • Lehto, S.G.1    Tamir, R.2    Deng, H.3    Klionsky, L.4    Kuang, R.5    Le, A.6
  • 151
    • 79951977972 scopus 로고    scopus 로고
    • Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect
    • Watabiki T, Kiso T, Kuramochi T, Yonezawa K, Tsuji N, Kohara A, et al. Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect. J Pharmacol Exp Ther 2011; 336: 743-50.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 743-750
    • Watabiki, T.1    Kiso, T.2    Kuramochi, T.3    Yonezawa, K.4    Tsuji, N.5    Kohara, A.6
  • 152
    • 79960306015 scopus 로고    scopus 로고
    • Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain
    • Watabiki T, Kiso T, Tsukamoto M, Aoki T, Matsuoka N. Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain. Biol Pharm Bull 2011; 34: 1105-8.
    • (2011) Biol Pharm Bull , vol.34 , pp. 1105-1108
    • Watabiki, T.1    Kiso, T.2    Tsukamoto, M.3    Aoki, T.4    Matsuoka, N.5
  • 154
    • 84878012703 scopus 로고    scopus 로고
    • TRPV1 antagonistic analgesic effect: A randomized study of AZD1386 in pain after third molar extraction
    • Quiding H, Jonzon B, Svensson O, Webster L, Reimfelt A, Karin A, et al. TRPV1 antagonistic analgesic effect: A randomized study of AZD1386 in pain after third molar extraction. Pain 2013; 154: 808-12.
    • (2013) Pain , vol.154 , pp. 808-812
    • Quiding, H.1    Jonzon, B.2    Svensson, O.3    Webster, L.4    Reimfelt, A.5    Karin, A.6
  • 156
    • 57149095621 scopus 로고    scopus 로고
    • GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models
    • Charrua A, Cruz CD, Narayanan S, Gharat L, Gullapalli S, Cruz F, et al. GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol 2009; 181: 379-86.
    • (2009) J Urol , vol.181 , pp. 379-386
    • Charrua, A.1    Cruz, C.D.2    Narayanan, S.3    Gharat, L.4    Gullapalli, S.5    Cruz, F.6
  • 157
    • 84855942949 scopus 로고    scopus 로고
    • Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist
    • Santos-Silva A, Charrua A, Cruz CD, Gharat L, Avelino A, Cruz F. Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist. Auton Neurosci 2012; 166: 35-8.
    • (2012) Auton Neurosci , vol.166 , pp. 35-38
    • Santos-Silva, A.1    Charrua, A.2    Cruz, C.D.3    Gharat, L.4    Avelino, A.5    Cruz, F.6
  • 159
    • 80052237527 scopus 로고    scopus 로고
    • Therapeutic targeting of TRP channels--the TR(i)P to pain relief
    • Eid SR. Therapeutic targeting of TRP channels--the TR(i)P to pain relief. Curr Top Med Chem 2011; 11: 2118-30.
    • (2011) Curr Top Med Chem , vol.11 , pp. 2118-2130
    • Eid, S.R.1
  • 161
    • 39149117718 scopus 로고    scopus 로고
    • Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management
    • Gomtsyan A, Bayburt EK, Schmidt RG, Surowy CS, Honore P, Marsh KC, et al. Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management. J Med Chem 2008; 51: 392-5.
    • (2008) J Med Chem , vol.51 , pp. 392-395
    • Gomtsyan, A.1    Bayburt, E.K.2    Schmidt, R.G.3    Surowy, C.S.4    Honore, P.5    Marsh, K.C.6
  • 162
    • 53849138741 scopus 로고    scopus 로고
    • (R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo
    • Surowy CS, Neelands TR, Bianchi BR, McGaraughty S, El Kouhen R, Han P, et al. (R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo. J Pharmacol Exp Ther 2008; 326: 879-88.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 879-888
    • Surowy, C.S.1    Neelands, T.R.2    Bianchi, B.R.3    McGaraughty, S.4    El Kouhen, R.5    Han, P.6
  • 163
    • 84863187892 scopus 로고    scopus 로고
    • Pharmacokinetics of the TRPV1 antagonist ABT-102 in healthy human volunteers: Population analysis of data from 3 phase 1 trials
    • Othman AA, Nothaft W, Awni WM, Dutta S. Pharmacokinetics of the TRPV1 antagonist ABT-102 in healthy human volunteers: Population analysis of data from 3 phase 1 trials. J Clin Pharmacol 2012; 52: 1028-41.
    • (2012) J Clin Pharmacol , vol.52 , pp. 1028-1041
    • Othman, A.A.1    Nothaft, W.2    Awni, W.M.3    Dutta, S.4
  • 164
    • 84875069303 scopus 로고    scopus 로고
    • Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: Pharmacokinetic/ pharmacodynamic analysis of three phase 1 trials
    • Othman AA, Nothaft W, Awni WM, Dutta S. Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: pharmacokinetic/ pharmacodynamic analysis of three phase 1 trials. Br J Clin Pharmacol 2013; 75: 1029-40.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 1029-1040
    • Othman, A.A.1    Nothaft, W.2    Awni, W.M.3    Dutta, S.4
  • 181
    • 84892495854 scopus 로고    scopus 로고
    • Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogs at TRPV1 channels
    • [Epub ahead of print]
    • De Petrocellis L, Schiano Moriello A, Fontana G, Sacchetti A, Passarella D, Appendino G, et al. Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogs at TRPV1 channels. Br J Pharmacol 2013 [Epub ahead of print].
    • (2013) Br J Pharmacol
    • De Petrocellis, L.1    Schiano, M.A.2    Fontana, G.3    Sacchetti, A.4    Passarella, D.5    Appendino, G.6
  • 186
    • 84892505359 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT00969787 (Accessed on: November 25, 2013).
  • 191
    • 79959289728 scopus 로고    scopus 로고
    • Characterization of 2-(2,6-dichloro-benzyl)-thiazolo [5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ 39729209) as a novel TRPV1 antagonist
    • Maher MP, Bhattacharya A, Ao H, Swanson N, Wu NT, Freedman J, et al. Characterization of 2-(2,6-dichloro-benzyl)-thiazolo [5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ 39729209) as a novel TRPV1 antagonist. Eur J Pharmacol 2011; 663: 40-50.
    • (2011) Eur J Pharmacol , vol.663 , pp. 40-50
    • Maher, M.P.1    Bhattacharya, A.2    Ao, H.3    Swanson, N.4    Wu, N.T.5    Freedman, J.6
  • 193
    • 84892523920 scopus 로고    scopus 로고
    • Web site of Pharmeste, a private biopharmaceutical company focused on the discovery and development of Transient Receptor Potential (TRP) channel therapeutics for the treatment of neuropathic pain, and other TRP-mediated diseases. Available at, (Accessed on: November 25, 2013)
    • Web site of Pharmeste, a private biopharmaceutical company focused on the discovery and development of Transient Receptor Potential (TRP) channel therapeutics for the treatment of neuropathic pain, and other TRP-mediated diseases. Available at: http://www.pharmeste.com/repository/contenuti/paragrafi/file/Phar mEste_Leaflet_Web.pdf (Accessed on: November 25, 2013).
  • 197
    • 84892512592 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 25, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/show/NCT00960180 (Accessed on: November 25, 2013).
  • 205
    • 0035979244 scopus 로고    scopus 로고
    • Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
    • Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA. 2001; 98: 9371-6.
    • (2001) Proc Natl Acad Sci USA. , vol.98 , pp. 9371-9376
    • Cravatt, B.F.1    Demarest, K.2    Patricelli, M.P.3    Bracey, M.H.4    Giang, D.K.5    Martin, B.R.6
  • 207
    • 23444432920 scopus 로고    scopus 로고
    • The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
    • Lambert DM, Fowler CJ. The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications. J Med Chem 2005; 48: 5059-87.
    • (2005) J Med Chem , vol.48 , pp. 5059-5087
    • Lambert, D.M.1    Fowler, C.J.2
  • 209
    • 0031779305 scopus 로고    scopus 로고
    • Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
    • Richardson JD, Kilo S, Hargreaves KM. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 1998; 75: 111-9.
    • (1998) Pain , vol.75 , pp. 111-119
    • Richardson, J.D.1    Kilo, S.2    Hargreaves, K.M.3
  • 211
    • 2442636258 scopus 로고    scopus 로고
    • Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels
    • Van Der Stelt M, Di Marzo V. Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem 2004; 271: 1827-34.
    • (2004) Eur J Biochem , vol.271 , pp. 1827-1834
    • Van Der Stelt, M.1    Di Marzo, V.2
  • 212
    • 34848905690 scopus 로고    scopus 로고
    • Vanilloid receptor 1 (TRPV1/VR1) colocalizes with fatty acid amide hydrolase (FAAH) in retinal amacrine cells
    • Zimov S, Yazulla S. Vanilloid receptor 1 (TRPV1/VR1) colocalizes with fatty acid amide hydrolase (FAAH) in retinal amacrine cells. Vis Neurosci 2007; 24: 581-91.
    • (2007) Vis Neurosci , vol.24 , pp. 581-591
    • Zimov, S.1    Yazulla, S.2
  • 213
    • 0344873175 scopus 로고    scopus 로고
    • Anandamide and vanilloid TRPV1 receptors
    • Ross RA. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 2003; 140: 790-801.
    • (2003) Br J Pharmacol , vol.140 , pp. 790-801
    • Ross, R.A.1
  • 214
    • 0037314324 scopus 로고    scopus 로고
    • Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release
    • Ahluwalia J, Yaqoob M, Urban L, Bevan S, Nagy I. Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. J Neurochem 2003; 84: 585-91.
    • (2003) J Neurochem , vol.84 , pp. 585-591
    • Ahluwalia, J.1    Yaqoob, M.2    Urban, L.3    Bevan, S.4    Nagy, I.5
  • 215
    • 33947319316 scopus 로고    scopus 로고
    • Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors
    • Maione S, De Petrocellis L, de Novellis V, Moriello AS, Petrosino S, Palazzo E, et al. Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br J Pharmacol 2007; 150: 766-81.
    • (2007) Br J Pharmacol , vol.150 , pp. 766-781
    • Maione, S.1    De Petrocellis, L.2    de Novellis, V.3    Moriello, A.S.4    Petrosino, S.5    Palazzo, E.6
  • 218
    • 40349114245 scopus 로고    scopus 로고
    • Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors
    • Vandevoorde S. Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors. Curr Top Med Chem 2008; 8: 247-67.
    • (2008) Curr Top Med Chem , vol.8 , pp. 247-267
    • Vandevoorde, S.1
  • 219
    • 71749101672 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands
    • Morera E, De Petrocellis L, Morera L, Moriello AS, Ligresti A, Nalli M, et al. Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands. Bioorg Med Chem Lett 2009; 19: 6806-9.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 6806-6809
    • Morera, E.1    De Petrocellis, L.2    Morera, L.3    Moriello, A.S.4    Ligresti, A.5    Nalli, M.6
  • 220
    • 84871003367 scopus 로고    scopus 로고
    • Tetrahydro-_-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels
    • Ortar G, De Petrocellis L, Moriello AS, Allarà M, Morera E, Nalli M, et al. Tetrahydro-_-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels. Bioorg Med Chem Lett 2013; 23: 138-42.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 138-142
    • Ortar, G.1    De Petrocellis, L.2    Moriello, A.S.3    Allarà, M.4    Morera, E.5    Nalli, M.6
  • 221
    • 20144376596 scopus 로고    scopus 로고
    • Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist
    • Swanson DM, Dubin AE, Shah C, Nasser N, Chang L. Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J Med Chem 2005; 48: 1857-72.
    • (2005) J Med Chem , vol.48 , pp. 1857-1872
    • Swanson, D.M.1    Dubin, A.E.2    Shah, C.3    Nasser, N.4    Chang, L.5
  • 222
    • 67349203919 scopus 로고    scopus 로고
    • Role of endocannabinoids and endovanilloids in Ca2+ signalling
    • De Petrocellis L, Di Marzo V. Role of endocannabinoids and endovanilloids in Ca2+ signalling. Cell Calcium 2009; 45: 611-24.
    • (2009) Cell Calcium , vol.45 , pp. 611-624
    • De Petrocellis, L.1    Di Marzo, V.2
  • 224
    • 18044402531 scopus 로고    scopus 로고
    • Therapeutic approaches to dermatotoxicity by sulfur mustard. I. Modulaton of sulfur mustard-induced cutaneous injury in the mouse ear vesicant model
    • Casillas RP, Kiser RC, Truxall JA, Singer AW, Shumaker SM, Niemuth NA, et al. Therapeutic approaches to dermatotoxicity by sulfur mustard. I. Modulaton of sulfur mustard-induced cutaneous injury in the mouse ear vesicant model. J Appl Toxicol 2000; 20: S145-51.
    • (2000) J Appl Toxicol , vol.20 , pp. 145-151
    • Casillas, R.P.1    Kiser, R.C.2    Truxall, J.A.3    Singer, A.W.4    Shumaker, S.M.5    Niemuth, N.A.6
  • 226
    • 65449121973 scopus 로고    scopus 로고
    • The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1
    • Fowler CJ, Naidu PS, Lichtman A, Onnis V. The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1. Br J Pharmacol 2009; 156: 412-9.
    • (2009) Br J Pharmacol , vol.156 , pp. 412-419
    • Fowler, C.J.1    Naidu, P.S.2    Lichtman, A.3    Onnis, V.4
  • 238
    • 84867340601 scopus 로고    scopus 로고
    • 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: Structureactivity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region
    • Kim MS, Ryu H, Kang DW, Cho SH, Seo S, Park YS, et al. 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: Structureactivity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region. J Med Chem 2012; 55: 8392-408.
    • (2012) J Med Chem , vol.55 , pp. 8392-8408
    • Kim, M.S.1    Ryu, H.2    Kang, D.W.3    Cho, S.H.4    Seo, S.5    Park, Y.S.6
  • 239
    • 84879017091 scopus 로고    scopus 로고
    • 2-(3-Fluoro-4 methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: Structure activity relationships of the 2-oxy pyridine C-region
    • Thorat SA, Kang DW, Ryu H, Kim MS, Kim HS, Ann J, et al. 2-(3-Fluoro-4 methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: Structure activity relationships of the 2-oxy pyridine C-region. Eur J Med Chem 2013; 64: 589-602.
    • (2013) Eur J Med Chem , vol.64 , pp. 589-602
    • Thorat, S.A.1    Kang, D.W.2    Ryu, H.3    Kim, M.S.4    Kim, H.S.5    Ann, J.6
  • 248
    • 79955647249 scopus 로고    scopus 로고
    • Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity
    • Valente P, Fernández-Carvajal A, Camprubí-Robles M, Gomis A, Quirce S, Viana F, et al. Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity. FASEB J 2011; 25: 1628-40.
    • (2011) FASEB J , vol.25 , pp. 1628-1640
    • Valente, P.1    Fernández-Carvajal, A.2    Camprubí-Robles, M.3    Gomis, A.4    Quirce, S.5    Viana, F.6
  • 249
    • 84861560216 scopus 로고    scopus 로고
    • An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain
    • Ponsati B, Carreño C, Curto-Reyes V, Valenzuela B, Duart MJ, Van den Nest W, et al. An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain. J Pharmacol Exp Ther 2012; 341: 634-45.
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 634-645
    • Ponsati, B.1    Carreño, C.2    Curto-Reyes, V.3    Valenzuela, B.4    Duart, M.J.5    Van den Nest, W.6
  • 250
    • 39749089798 scopus 로고    scopus 로고
    • Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice
    • Christoph T, Bahrenberg G, De Vry J, Englberger W, Erdmann VA, Frech M, et al. Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. Mol Cell Neurosci 2008; 37: 579-89.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 579-589
    • Christoph, T.1    Bahrenberg, G.2    De Vry, J.3    Englberger, W.4    Erdmann, V.A.5    Frech, M.6
  • 254
    • 84857237101 scopus 로고    scopus 로고
    • TRPV1-dependent and-independent alterations in the limbic cortex of neuropathic mice: Impact on glial caspases and pain perception
    • Giordano C, Cristino L, Luongo L, Siniscalco D, Petrosino S, Piscitelli F, et al. TRPV1-dependent and-independent alterations in the limbic cortex of neuropathic mice: Impact on glial caspases and pain perception. Cereb Cortex 2012; 22: 2495-518.
    • (2012) Cereb Cortex , vol.22 , pp. 2495-2518
    • Giordano, C.1    Cristino, L.2    Luongo, L.3    Siniscalco, D.4    Petrosino, S.5    Piscitelli, F.6
  • 255
    • 67649998667 scopus 로고    scopus 로고
    • Anxiolyticlike effects induced by blockade of transient receptor potential vanilloid type 1 channels in the medial prefrontal cortex of rats
    • Aguiar DC, Terzian AL, Guimarães FS, Moreira FA. Anxiolyticlike effects induced by blockade of transient receptor potential vanilloid type 1 channels in the medial prefrontal cortex of rats. Psychopharmacol 2009; 205: 217-25.
    • (2009) Psychopharmacol , vol.205 , pp. 217-225
    • Aguiar, D.C.1    Terzian, A.L.2    Guimarães, F.S.3    Moreira, F.A.4
  • 257
    • 84883307679 scopus 로고    scopus 로고
    • Effects of endocannabinoid and endovanilloid systems on aversive memory extinction
    • Laricchiuta D, Centonze D, Petrosini L. Effects of endocannabinoid and endovanilloid systems on aversive memory extinction. Behav Brain Res 2013; 256C: 101-7.
    • (2013) Behav Brain Res , vol.256 C , pp. 101-107
    • Laricchiuta, D.1    Centonze, D.2    Petrosini, L.3
  • 259
    • 33644830973 scopus 로고    scopus 로고
    • Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection
    • Pegorini S, Zani A, Braida D, Guerini-Rocco C, Sala M. Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection. Br J Pharmacol 2006; 147: 552-9.
    • (2006) Br J Pharmacol , vol.147 , pp. 552-559
    • Pegorini, S.1    Zani, A.2    Braida, D.3    Guerini-Rocco, C.4    Sala, M.5
  • 260
    • 84872004645 scopus 로고    scopus 로고
    • Increased expression of TRPV1 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy
    • Sun FJ, Guo W, Zheng DH, Zhang CQ, Li S, Liu SY, et al. Increased expression of TRPV1 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy. J Mol Neurosci 2013; 49: 182-93.
    • (2013) J Mol Neurosci , vol.49 , pp. 182-193
    • Sun, F.J.1    Guo, W.2    Zheng, D.H.3    Zhang, C.Q.4    Li, S.5    Liu, S.Y.6
  • 261
    • 84885421108 scopus 로고    scopus 로고
    • Piperine exerts anti-seizure effects via the TRPV1 receptor in mice
    • Chen CY, Li W, Qu KP, Chen CR. Piperine exerts anti-seizure effects via the TRPV1 receptor in mice. Eur J Pharmacol 2013; 714: 288-94.
    • (2013) Eur J Pharmacol , vol.714 , pp. 288-294
    • Chen, C.Y.1    Li, W.2    Qu, K.P.3    Chen, C.R.4
  • 264
    • 63349100394 scopus 로고    scopus 로고
    • Hot flash: TRPV channels in the brain
    • Kauer JA, Gibson HE. Hot flash: TRPV channels in the brain. Trends Neurosci 2009; 32: 215-24.
    • (2009) Trends Neurosci , vol.32 , pp. 215-224
    • Kauer, J.A.1    Gibson, H.E.2
  • 266
  • 268
    • 39449097036 scopus 로고    scopus 로고
    • TRPV1 receptors in the central nervous system: Potential for previously unforeseen therapeutic applications
    • Starowicz K, Cristino L, Di Marzo V. TRPV1 receptors in the central nervous system: Potential for previously unforeseen therapeutic applications. Curr Pharm Des 2008; 14: 42-54
    • (2008) Curr Pharm Des , vol.14 , pp. 42-54
    • Starowicz, K.1    Cristino, L.2    Di Marzo, V.3
  • 269
    • 80052223776 scopus 로고    scopus 로고
    • Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials
    • Kissin I, Szallasi A. Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials. Curr Top Med Chem 2011; 11: 2159-70.
    • (2011) Curr Top Med Chem , vol.11 , pp. 2159-2170
    • Kissin, I.1    Szallasi, A.2
  • 270
    • 79955639903 scopus 로고    scopus 로고
    • Inhibitory CB1 and activating/ desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin
    • Engel MA, Izydorczyk I, Mueller-Tribbensee SM, Becker C, Neurath MF, Reeh PW. Inhibitory CB1 and activating/ desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin. Neuropeptides 2011; 45: 229-37.
    • (2011) Neuropeptides , vol.45 , pp. 229-237
    • Engel, M.A.1    Izydorczyk, I.2    Mueller-Tribbensee, S.M.3    Becker, C.4    Neurath, M.F.5    Reeh, P.W.6
  • 271
    • 33644766044 scopus 로고    scopus 로고
    • Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors
    • Maione S, Bisogno T, de Novellis V, Palazzo E, Cristino L, Valenti M, et al. Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. J Pharmacol Exp Ther 2006; 316: 969-82.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 969-982
    • Maione, S.1    Bisogno, T.2    de Novellis, V.3    Palazzo, E.4    Cristino, L.5    Valenti, M.6
  • 272
    • 79959705331 scopus 로고    scopus 로고
    • Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey
    • Kawahara H, Drew GM, Christie MJ, Vaughan CW. Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey. Br J Pharmacol 2011; 163: 1214-22.
    • (2011) Br J Pharmacol , vol.163 , pp. 1214-1222
    • Kawahara, H.1    Drew, G.M.2    Christie, M.J.3    Vaughan, C.W.4
  • 273
    • 79954511348 scopus 로고    scopus 로고
    • Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptormediated endocannabinoid retrograde disinhibition
    • Liao HT, Lee HJ, Ho YC, Chiou LC. Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptormediated endocannabinoid retrograde disinhibition. Br J Pharmacol 2011; 163: 330-45.
    • (2011) Br J Pharmacol , vol.163 , pp. 330-345
    • Liao, H.T.1    Lee, H.J.2    Ho, Y.C.3    Chiou, L.C.4
  • 274
    • 33750708298 scopus 로고    scopus 로고
    • Post-operative pain behaviour in rats is reduced after single high-concentration capsaicin application
    • Pospisilova E, Palecek J. Post-operative pain behaviour in rats is reduced after single high-concentration capsaicin application. Pain 2006; 125: 233-43.
    • (2006) Pain , vol.125 , pp. 233-243
    • Pospisilova, E.1    Palecek, J.2
  • 275
    • 49849104617 scopus 로고    scopus 로고
    • Vanilloid-induced conduction analgesia: Selective, dosedependent, long-lasting, with a low level of potential neurotoxicity
    • Kissin I. Vanilloid-induced conduction analgesia: Selective, dosedependent, long-lasting, with a low level of potential neurotoxicity. Anesth Analg 2008; 107: 271-81.
    • (2008) Anesth Analg , vol.107 , pp. 271-281
    • Kissin, I.1
  • 276
    • 78049367698 scopus 로고    scopus 로고
    • The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
    • Fischer MJ, Leffler A, Niedermirtl F, Kistner K, Eberhardt M, Reeh PW, et al. The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors. J Biol Chem 2010; 285: 34781-92.
    • (2010) J Biol Chem , vol.285 , pp. 34781-34792
    • Fischer, M.J.1    Leffler, A.2    Niedermirtl, F.3    Kistner, K.4    Eberhardt, M.5    Reeh, P.W.6
  • 277
    • 84874591159 scopus 로고    scopus 로고
    • Paradoxic effects of propofol on visceral pain induced by various TRPV1 agonists
    • Ji W, Cui C, Zhang Z, Liang J. Paradoxic effects of propofol on visceral pain induced by various TRPV1 agonists. Exp Ther Med 2013; 5: 1259-63.
    • (2013) Exp Ther Med , vol.5 , pp. 1259-1263
    • Ji, W.1    Cui, C.2    Zhang, Z.3    Liang, J.4
  • 278
    • 84876682953 scopus 로고    scopus 로고
    • The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat
    • Takechi K, Carstens MI, Klein AH, Carstens E. The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat. Anesth Analg 2013; 116: 932-8.
    • (2013) Anesth Analg , vol.116 , pp. 932-938
    • Takechi, K.1    Carstens, M.I.2    Klein, A.H.3    Carstens, E.4
  • 280
    • 84885459794 scopus 로고    scopus 로고
    • Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia
    • Vanden Abeele F, Kondratskyi A, Dubois C, Shapovalov G, Gkika D, Busserolles J, et al. Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia. J Cell Sci 2013; 126: 4479-89.
    • (2013) J Cell Sci , vol.126 , pp. 4479-4489
    • Vanden Abeele, F.1    Kondratskyi, A.2    Dubois, C.3    Shapovalov, G.4    Gkika, D.5    Busserolles, J.6
  • 281
    • 54349124083 scopus 로고    scopus 로고
    • General anesthetics sensitize the capsaicin receptor transient receptor potential V1
    • Cornett PM, Matta JA, Ahern GP. General anesthetics sensitize the capsaicin receptor transient receptor potential V1. Mol Pharmacol 2008; 74: 1261-8.
    • (2008) Mol Pharmacol , vol.74 , pp. 1261-1268
    • Cornett, P.M.1    Matta, J.A.2    Ahern, G.P.3
  • 282
    • 84892509476 scopus 로고    scopus 로고
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at, (Accessed on: November 26, 2013)
    • ClinicalTrials. gov A service of the U.S. National Institutes of Health. Available at: http://clinicaltrials.gov/ct2/results?term= propofol+ postoperative+pain&Search=Search (Accessed on: November 26, 2013).


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