In vitro activity of temocillin against multidrug-resistant clinical isolates of Escherichia coli, Klebsiella spp. and Enterobacter spp., and evaluation of high-level temocillin resistance as a diagnostic marker for OXA-48 carbapenemase

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 2, 2014, Pages 564-567

  Woodford, Neil ^a   Pike, Rachel ^a   Meunier, Daniele ^a   Loy, Richard ^a   Hill, Robert ^a   Hopkins, Katie L ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Enterobacteriaceae; ESBLs; KPC; NDM; VIM

Indexed keywords

BETA LACTAMASE AMPC; CARBAPENEM; CARBAPENEMASE; EXTENDED SPECTRUM BETA LACTAMASE; IMIPENEM; TEMOCILLIN;

ANTIBIOTIC RESISTANCE; DRUG ACTIVITY; ENTEROBACTER; ESCHERICHIA COLI; HYDROLYSIS; IN VITRO STUDY; KLEBSIELLA; LETTER; NONHUMAN; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; URINARY TRACT INFECTION;

ENTEROBACTERIACEAE; ESBLS; KPC; NDM; VIM;

BACTERIAL PROTEINS; BETA-LACTAMASES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROBACTER; ESCHERICHIA COLI; HUMANS; KLEBSIELLA; MICROBIAL SENSITIVITY TESTS; PENICILLINS;

EID: 84892471881     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt383     Document Type: Letter

References (10)

1. Livermore DM, Tulkens PM. Temocillin revived. J Antimicrob Chemother 2009; 63: 243-5.
2. Adams-Haduch JM, Potoski BA, Sidjabat HE et al. Activity of temocillin against KPC-producing Klebsiella pneumoniae and Escherichia coli. Antimicrob Agents Chemother 2009; 53: 2700-1.
3. Livermore DM, Warner M, Mushtaq S et al. What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline. Int J Antimicrob Agents 2011; 37: 415-9.
4. Nordmann P, Gniadkowski M, Giske CG et al. Identification and screening of carbapenemase-producing Enterobacteriaceae. Clin Microbiol Infect 2012; 18: 432-8.
5. Tijet N, Boyd D, Patel SN et al. Evaluation of the Carba NP test for rapid detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother 2013; 57:4578-80.
6. Huang TD, Berhin C, Bogaerts P et al. Prevalence and mechanisms of resistance to carbapenems in Enterobacteriaceae isolates from 24 hospitals in Belgium. J Antimicrob Chemother 2013; 68: 1832-7.
7. Hartl R, Widhalm S, Kerschner H et al. Temocillin and meropenem to discriminate resistance mechanisms leading to decreased carbapenem susceptibility with focus on OXA-48 in Enterobacteriaceae. Clin Microbiol Infect 2013; 19: E230-2.
8. vanDijk K, Voets GM, Scharringa J et al. Adisc diffusion assay for detection of class A, B and OXA-48 carbapenemases in Enterobacteriaceae using phenyl boronic acid, dipicolinic acid and temocillin. Clin Microbiol Infect 2013; doi:10.1111/1469-0691.12322.
9. Wooton M, for the BSAC Working Party on Susceptibility Testing. BSAC Methods for Antimicrobial Susceptibility Testing (Version 12, May 2013). http://bsac.org.uk/wp-content/uploads/2012/02/Version-12-Apr-2013_ final.pdf. (16 September 2013, date last accessed).
10. Balakrishnan I, Awad-El-Kariem FM, Aali A et al. Temocillin use in England: clinical and microbiological efficacies in infections caused by extended-spectrum and/or derepressed AmpC β-lactamase-producing Enterobacteriaceae. J Antimicrob Chemother 2011; 66: 2628-31.