Increased permeability of blood-brain barrier is mediated by serine protease during Cryptococcus meningitis

Journal of International Medical Research

Volumn 42, Issue 1, 2014, Pages 85-92

  Xu, Chi Yu ^a   Zhu, Hong Mei ^b   Wu, Jian Hua ^c   Wen, Hai ^b   Liu, Cui Jie ^a  

^a JINAN MILITARY GENERAL HOSPITAL   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

blood brain barrier; brain microvascular endothelial cell; Cryptococcus meningitis; Cryptococcus neoformans; Serine protease; transendothelial permeability

Indexed keywords

APROTININ; HORSERADISH PEROXIDASE; MESSENGER RNA; SERINE PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL STRUCTURE; CONTROLLED STUDY; CRYPTOCOCCAL MENINGITIS; CRYPTOCOCCUS NEOFORMANS; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULAR ENDOTHELIAL CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION;

BLOOD-BRAIN BARRIER; BRAIN MICROVASCULAR ENDOTHELIAL CELL; CRYPTOCOCCUS MENINGITIS; CRYPTOCOCCUS NEOFORMANS; SERINE PROTEASE; TRANSENDOTHELIAL PERMEABILITY;

ANIMALS; BASE SEQUENCE; BLOOD-BRAIN BARRIER; DISEASE MODELS, ANIMAL; DNA PRIMERS; MALE; MENINGITIS, CRYPTOCOCCAL; MICROSCOPY, ELECTRON; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERINE PROTEASES;

EID: 84892456497     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060513504365     Document Type: Article

References (23)

1. Esposito V,Viglietti R,Gargiulo M, et al.Successful treatment of Cryptococcal meningitis with a combination of liposomal amphotericin B, flucytosine and posaconazole: two case reports.In Vivo. 2009;23:465-468.
2. Mwaba P,Mwansa J,Chintu C, et al.Clinical presentation, natural history, and cumulative death rates of 230 adults with primary cryptococcal meningitis in Zambian AIDS patients treated under local conditions.Postgrad Med J. 2001;77:769-773.
3. Bicanic T,Muzoora C,Brouwer AE, et al.Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients.Clin Infect Dis. 2009;49:702-709.
4. Moosa MY,Coovadia YM.Cryptococcal meningitis in Durban, South Africa: a comparison of clinical features, laboratory findings, and outcome for human immunodeficiency virus (HIV)-positive and HIV-negative patients.Clin Infect Dis. 1997;24:131-134.
5. Powderly WG.Therapy for cryptococcal meningitis in patients with AIDS.Clin Infect Dis. 1992;14:S54-S59.
6. French N,Gray K,Watera C, et al.Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults.AIDS. 2002;16:1031-1038.
7. Kim JC,Crary B,Chang YC, et al.Cryptococcus neoformans activates RhoGTPases followed by PKC, FAK and ezrin to enhance traversal across the blood-brain barrier.J Biol Chem. 2012;10:1074-1074.
8. Chang YC,Stins MF,McCaffery MJ, et al.Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier.Infect Immun. 2004;72:4985-4995.
9. Charlier C,Nielsen K,Daou S, et al.Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans.Infect Immun. 2009;77:120-127.
10. Charlier C,Chrétien F,Baudrimont M, et al.Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier.Am J Pathol. 2005;166:421-432.
11. Boitano S,Flynn AN,Sherwood CL, et al.Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2.Am J Physiol Lung Cell Mol Physiol. 2011;300:L605-L614.
12. Chen SC,Wright LC,Santangelo RT, et al.Identification of extracellular phospholipase B, lysophospholipase, and acyltransferase produced by Cryptococcus neoformans.Infect Immun. 1997;65:405-411.
13. Rodrigues ML,dos Reis FC,Puccia R, et al.Cleavage of human fibronectin and other basement membrane-associated proteins by a Cryptococcus neoformans serine proteinase.Microb Pathog. 2003;34:65-71.
14. Saunders WB,Bayless KJ,Davis GE.MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices.J Cell Sci. 2005;118:2325-2340.
15. Stroud JD,Baicu CF,Barnes MA, et al.Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment.Am J Physiol Heart Circ Physiol. 2002;282:H2324-H2335.
16. Koo BH,Han JH,Yeom YI, et al.Thrombin-dependent MMP-2 activity is regulated by heparan sulfate.J Biol Chem. 2010;285:41270-41279.
17. Nicola PA,Taylor CJ,Wang S, et al.Transport activities involved in intracellular pH recovery following acid and alkali challenges in rat brain microvascular endothelial cells.Pflugers Arch. 2008;456:801-812.
18. Jong AY,Stins MF,Huang SH, et al.Traversal of Candida albicans across human blood-brain barrier in vitro.Infect Immun. 2001;69:4536-4544.
19. Arihiro K,Umemura S,Kurosumi M, et al.Comparison of evaluations for hormone receptors in breast carcinoma using two manual and three automated immunohistochemical assays.Am J Clin Pathol. 2007;127:356-365.
20. Sukumaran SK,Prasadarao NV.Escherichia coli K1 invasion increases human brain microvascular endothelial cell monolayer permeability by disassembling vascular-endothelial cadherins at tight junctions.J Infect Dis. 2003;188:1295-1309.
21. Olszewski MA,Noverr MC,Chen GH, et al.Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion.Am J Pathol. 2004;164:1761-1771.
22. Santangelo R,Zoellner H,Sorrell T, et al.Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model.Infect Immun. 2004;72:2229-2239.
23. Nagy Z,Kolev K,Csonka E, et al.Perturbation of the integrity of the blood-brain barrier by fibrinolytic enzymes.Blood Coagul Fibrinolysis. 1998;9:471-478.