A novel microfluidic wound model for testing antimicrobial agents against Staphylococcus pseudintermedius biofilms

Journal of Nanobiotechnology

Volumn 12, Issue 1, 2014, Pages

  Terry, Jacob ^a   Neethirajan, Suresh ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Antibiofilm; Biofilms; Microfluidics; Staphylococcus pseudintermedius; Wound model

Indexed keywords

ANTI-BIOFILM; ANTIMICROBIAL THERAPY; EXPERIMENTAL CONDITIONS; MICRO-FLUIDIC DEVICES; MICROFLUIDIC MODELING; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS PSEUDINTERMEDIUS; SURGICAL SITE INFECTIONS;

ANIMALS; BIOFILMS; COLLAGEN; LABORATORIES;

MICROFLUIDICS;

CLARITHROMYCIN; COLLAGEN; DISPERSIN B; GENTAMICIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL GROWTH; BIOFILM; CONTROLLED STUDY; DRUG EFFICACY; MICROFLUIDIC ANALYSIS; MICROTITER PLATE ASSAY; STAPHYLOCOCCUS INFECTION; STAPHYLOCOCCUS PSEUDINTERMEDIUS; WOUND INFECTION;

ANIMALIA; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS PSEUDINTERMEDIUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOFILMS; EQUIPMENT DESIGN; GENTAMICINS; GLYCOSIDE HYDROLASES; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MICROFLUIDIC ANALYTICAL TECHNIQUES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; SURGICAL WOUND INFECTION;

EID: 84892428621     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/1477-3155-12-1     Document Type: Article

References (21)

1. Frank LA, Loeffler A. Meticillin-resistant Staphylococcus pseudintermedius: clinical challenge and treatment options. Vet Dermatol 2012, 23:283-291. 10.1111/j.1365-3164.2012.01047.x, 22486942.
2. Bryan J, Frank LA, Rohrbach BW, Burgette LJ, Cain CL, Bemis DA. Treatment outcome of dogs with meticillin-resistant and meticillin-susceptible Staphylococcus pseudintermedius pyoderma. Vet Dermatol 2012, 23:361-368. 10.1111/j.1365-3164.2012.01034.x, 22364681.
3. van Duijkeren E, Catry B, Greko C, Moreno MA, Pomba MC, Pyorala S, Ruzauskas M, Sanders P, Threlfall EJ, Torren-Edo J, Torneke K, A. Scientific Advisory Group on Antimicrobials (SAGM) Review on methicillin-resistant Staphylococcus pseudintermedius. J Antimicrob Chemother 2011, 66:2705-2714. 10.1093/jac/dkr367, 21930571, A. Scientific Advisory Group on Antimicrobials (SAGM).
4. Daeschlein G. Antimicrobial and antiseptic strategies in wound management. Int Wound J 2013, 10:9-14. 10.1111/iwj.12175, 24251838.
5. Zhang M, Li H, Ma H, Qin J. A simple microfluidic strategy for cell migration assay in an in vitro wound-healing model. Wound Repair Regen 2013, 21:897-903.
6. Larko E. Development of an in vitro model for testing novel antimicrobial substances: effects of established wound bacterial biofilm on cultured human macrophages, In Chemical and Biological Engineering 2011, Gothenburg, Sweden: Chalmers Unviersity of Technology.
7. Torkian BA, Yeh AT, Engel R, Sun CH, Tromberg BJ, Wong BJ. Modeling aberrant wound healing using tissue-engineered skin constructs and multiphoton microscopy. Arch Facial Plast Surg 2004, 6:180-187. 10.1001/archfaci.6.3.180, 15148128.
8. Werthen M, Henriksson L, Jensen PO, Sternberg C, Givskov M, Bjarnsholt T. An in vitro model of bacterial infections in wounds and other soft tissues. APMIS 2010, 118:156-164. 10.1111/j.1600-0463.2009.02580.x, 20132180.
9. Neethirajan S, Karig D, Kumar A, Mukherjee P, Retterer ST, Doktycz MJ. Biofilms in microfluidic devices. Encyclopedia of Nanotechnology 2012, 213-219. New York: Springer, Bhushan B.
10. Chen CH, Lu Y, Sin ML, Mach KE, Zhang DD, Gau V, Liao JC, Wong PK. Antimicrobial susceptibility testing using high surface-to-volume ratio microchannels. Anal Chem 2010, 82:1012-1019. 10.1021/ac9022764, 2821038, 20055494.
11. Sato K, Sasaki N, Svahn HA, Sato K. Microfluidics for nano-pathophysiology. Adv Drug Deliv Rev 2013, doi: 10.1016/j.addr.2013.08.009.
12. Halder P, Nasabi M, Lopez FJ, Jayasuriya N, Bhattacharya S, Deighton M, Mitchell A, Bhuiyan MA. A novel approach to determine the efficacy of patterned surfaces for biofouling control in relation to its microfluidic environment. Biofouling 2013, 29:697-713. 10.1080/08927014.2013.800192, 23789960.
13. Kim J, Park HD, Chung S. Microfluidic approaches to bacterial biofilm formation. Molecules 2012, 17:9818-9834. 10.3390/molecules17089818, 22895027.
14. Brindle ER, Miller DA, Stewart PS. Hydrodynamic deformation and removal of Staphylococcus epidermidis biofilms treated with urea, chlorhexidine, iron chloride, or DispersinB. Biotechnol Bioeng 2011, 108:2968-2977. 10.1002/bit.23245, 21732324.
15. Dicicco M, Neethirajan S, Singh A, Weese JS. Efficacy of clarithromycin on biofilm formation of methicillin-resistant Staphylococcus pseudintermedius. BMC Vet Res 2012, 8:225. 10.1186/1746-6148-8-225, 3534386, 23171620.
16. Lee JH, Kaplan JB, Lee WY. Microfluidic devices for studying growth and detachment of Staphylococcus epidermidis biofilms. Biomed Microdevices 2008, 10:489-498. 10.1007/s10544-007-9157-0, 18204904.
17. Stepanovic S, Vukovic D, Hola V, Di Bonaventura G, Djukic S, Cirkovic I, Ruzicka F. Quantification of biofilm in microtiter plates: overview of testing conditions and practical recommendations for assessment of biofilm production by staphylococci. APMIS 2007, 115:891-899. 10.1111/j.1600-0463.2007.apm_630.x, 17696944.
18. Gawande PV, Yakandawala N, Vetri KL, Madhyashtha S. In vitro antimicrobial and antibiofilm activity of DispersinB-Tricolsan wound gel against chronic wound-associated bacteria. Open Antimicrob Agents J 2011, 3:12-16.
19. Osland AM, Vestby LK, Fanuelsen H, Slettemeas JS, Sunde M. Clonal diversity and biofilm-forming ability of methicillin-resistant Staphylococcus pseudintermedius. J Antimicrob Chemother 2012, 67:841-848. 10.1093/jac/dkr576, 22258925.
20. Liu Y, Tay JH. Metabolic response of biofilm to shear stress in fixed-film culture. J Appl Microbiol 2001, 90:337-342. 10.1046/j.1365-2672.2001.01244.x, 11298227.
21. Rotstein OD, Pruett TL, Simmons RL. Mechanisms of microbial synergy in polymicrobial surgical infections. Rev Infect Dis 1985, 7:151-170. 10.1093/clinids/7.2.151, 3890095.