Dendritic cell-based vaccines: Shining the spotlight on signal 3

OncoImmunology

Volumn 2, Issue 11, 2013, Pages

  Linette, Gerald P ^a   Carreno, Beatriz M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD40L; CD8+ T cells; Dendritic cells; IL 12; Melanoma; Vaccines

Indexed keywords

DENDRITIC CELL VACCINE; INTERLEUKIN 12; INTERLEUKIN 12P70;

ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CANCER IMMUNIZATION; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DRUG EFFICACY; HUMAN; MELANOMA; NONHUMAN; PARACRINE SIGNALING;

EID: 84892426495     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.26512     Document Type: Article

References (7)

1. Kreutz M, Tacken PJ, Figdor CG. Targeting dendritic cells-why bother? Blood 2013; 121:2836-44; PMID:23390195; http://dx.doi.org/10.1182/blood-2012-09-452078.
2. Mescher MF, Curtsinger JM, Agarwal P, Casey KA, Gerner M, Hammerbeck CD, Popescu F, Xiao Z. Signals required for programming effector and memory development by CD8+ T cells. Immunol Rev 2006; 211:81-92; PMID:16824119; http://dx.doi. org/10.1111/j.0105-2896.2006.00382.x.
3. Agarwal P, Raghavan A, Nandiwada SL, Curtsinger JM, Bohjanen PR, Mueller DL, Mescher MF. Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory. J Immunol 2009; 183:1695-704; PMID:19592655; http://dx.doi.org/10.4049/jimmunol.0900592.
4. Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL. Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. J Immunol 2010; 185:4988-92; PMID:20935204; http://dx.doi.org/10.4049/jimmunol.1002042.
5. Carreno BM, Becker-Hapak M, Huang A, Chan M, Alyasiry A, Lie WR, Aft RL, Cornelius LA, Trinkaus KM, Linette GP. IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity. J Clin Invest 2013; 123:3383-94; PMID:23867552; http://dx.doi. org/10.1172/JCI68395.
6. Gerner MY, Heltemes-Harris LM, Fife BT, Mescher MF. Cutting edge: IL-12 and type I IFN differentially program CD8 T cells for programmed death 1 re-expression levels and tumor control. J Immunol 2013; 191:1011-5; PMID:23804712; http://dx.doi. org/10.4049/jimmunol.1300652.
7. Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, Bianco A, Steckel B, Moro M, Crosti M, et al. Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses. Blood 2013; 122:932-42; PMID:23794066; http://dx.doi.org/10.1182/blood-2013-04-495424.