Effect of cadmium on rat leydig cell testosterone production and DNA integrity in vitro

Biomedical and Environmental Sciences

Volumn 26, Issue 9, 2013, Pages 769-773

  Qing, Liu ^a   Hong, Gu Jian ^a   Yan, Yuan ^a   Zhong, Liu Xue ^a   Jun, Wang Ya ^a   Dong, Wang Han ^a   Ping, Liu Zong ^a   Yuan, Wang Zong ^a   Chun, Bian Jian ^a  

^a YANGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CADMIUM; DNA; TESTOSTERONE;

ANIMAL; BIOSYNTHESIS; CELL CULTURE; DNA DAMAGE; DRUG EFFECT; ENZYMOLOGY; LETTER; LEYDIG CELL; MALE; METABOLISM; RAT; SECRETION (PROCESS); DRUG EFFECTS; TOXICITY;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CADMIUM; CELLS, CULTURED; DNA; DNA DAMAGE; LEYDIG CELLS; MALE; RATS; TESTOSTERONE;

EID: 84892418358     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: 10.3967/0895-3988.2013.09.009     Document Type: Letter

References (17)

1. ATSDR. Toxicological Profile for Cadmium[R]. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA. July 1999.
2. Zhou T, Zhou G, Song W, et al. Cadmium-induced apoptosis and changes in expression of p53, c-jun and MT-I genes in testes and ventral prostate of rats. Toxicology, 1999; 142(1), 1-13.
3. Haouem S, Najjar MF, El HA, et al. Accumulation of cadmium and its effects on testis function in rats given diet containing cadmium-polluted radish bulb. Exp Toxicol Pathol, 2008; 59(5), 307-11.
4. Zhou T, Jia X, Chapin RE, et al. Cadmium at a non-toxic dose alters gene expression in mouse testes. Toxicol Lett, 2004; 154(3), 191-200.
5. Lee MS, Hong SJ, Choi HR, et al. Testosterone productivity and histostructural changes of autotransplanted rat Leydig cells. Yonsei Med J, 1994; 35, 260-70.
6. Kerr JB, Robertson DM, de Kretser DM. Morphological and functional characterization of interstitial cells from mouse testes fractionated on Percoll density gradients. Endocrinology, 1985; 116, 1030-43.
7. Wiebe JP. Steroidogenesis in rat leydig cells: changes in activity of 5-Ane and 5-ene 3beta-hydroxysteroid dehydrogenases during sexual maturation. Endocrinology, 1976; 98, 505-13.
8. Singh NP, McCoy MT, Tice RR, et al. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res, 1988; 175, 184-91.
9. Ellis GB, Desjardins C, Fraser HM. Control of pulsatile LH release in male rats. Neuroendocrinology, 1983; 37(3), 177-83.
10. Zhang M, He Z, Wen L, et al. Cadmium suppresses the proliferation of piglet Sertoli cells and causes their DNA damage, cell apoptosis and aberrant ultrastructure. Reprod Biol Endocrinol, 2010; 8, 97.
11. Jia X, Zhang H, and Liu X. Low levels of cadmium exposure induce DNA damage and oxidative stress in the liver of Oujiang colored common carp Cyprinus carpio var. color. Fish Physiol Biochem, 2011; 37(1), 97-103.
12. Schar P. Spontaneous DNA damage, genome instability, and cancer-when DNA replication escapes control. Cell, 2001; 104(3), 329-32.
13. Singh KP, Kumari R, Pevey C, et al. Long duration exposure to cadmium leads to increased cell survival, decreased DNA repair capacity, and genomic instability in mouse testicular Leydig cells. Cancer Lett, 2009; 279(1), 84-92.
14. Yang JM, Arnush M, Chen QY, et al. Cadmium-induced damage to primary cultures of rat Leydig cells. Reprod Toxicol, 2003; 17(5), 553-60.
15. Kim HH, Kwak DH, Yon JM, et al. Differential expression of 3beta-hydroxysteroid dehydrogenase mRNA in rat testes exposed to endocrine disruptors. J Reprod Dev, 2007; 53(3), 465-71.
16. Fatur T, Lah TT, Filipic M. Cadmium inhibits repair of UV-, methyl methanesulfonate-And N-methyl-N-nitrosoureainduced DNA damage in Chinese hamster ovary cells. Mutat Res, 2003; 529(1-2), 109-16.
17. Badisa VL, Latinwo LM, Odewumi CO, et al. Mechanism of DNA damage by cadmium and interplay of antioxidant enzymes and agents. Environ Toxicol, 2007, 22(2), 144-51.