Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library

DMM Disease Models and Mechanisms

Volumn 7, Issue 1, 2014, Pages 163-169

  Wang, Xingang ^a,b   Robertson, Anne L ^c   Li, Jingyu ^d,e   Chai, Ruth Jinfen ^a   Haishan, Wang ^a   Sadiku, Pranvera ^c   Ogryzko, Nikolay V ^c   Everett, Martin ^f   Yoganathan, Kanagasundaram ^f   Luo, Hongbo Robert ^d   Renshaw, Stephen A ^c   Ingham, Philip W ^a,c,g  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b Tianjin International Joint Academy of Biotechnology and Medicine   (China)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

^e Hebei NormalUniversity   (China)

^f MerLion Pharmaceuticals Pte Ltd   (Singapore)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Drug screen; Migration; Neutrophil; Recruitment; Zebrafish

Indexed keywords

ANTIBIOTIC AGENT; FUNGAL EXTRACT; GREEN FLUORESCENT PROTEIN; NATURAL PRODUCT; NEUTROPHIL INHIBITORY FACTOR; PF 1052; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STERIGMATOCYSTIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL LABELING; CELL MEMBRANE; CELL VIABILITY; CHEMOTAXIS ASSAY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; FEASIBILITY STUDY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE MIGRATION; MACROPHAGE MIGRATION; MALE; MOLECULAR LIBRARY; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PSEUDOPODIUM; ZEBRA FISH;

DRUG SCREEN; MIGRATION; NEUTROPHIL; RECRUITMENT; ZEBRAFISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTI-BACTERIAL AGENTS; APOPTOSIS; CELL MEMBRANE; CHEMOTAXIS; GREEN FLUORESCENT PROTEINS; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; NAPHTHALENES; NEUTROPHIL INFILTRATION; NEUTROPHILS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINONES; STERIGMATOCYSTIN; SUBCELLULAR FRACTIONS; TRANSGENES; ZEBRAFISH;

EID: 84892414221     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.012047     Document Type: Article

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