Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Chen, Tufeng ^a,b   Wu, Di ^a   Moskaluk, Christopher A ^a   Fu, Zheng ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ICK PROTEIN KINASE; MAK PROTEIN KINASE; MOK PROTEIN KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG; ICK PROTEIN, HUMAN; ICK PROTEIN, MOUSE; MAK PROTEIN, HUMAN; MAK PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; MOK PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; STK30 PROTEIN, MOUSE; TUMOR ANTIGEN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON; COLON ADENOCARCINOMA; CONTROLLED STUDY; DOWN REGULATION; DUODENUM; EMBRYO; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE; INTESTINE ADENOMA; INTESTINE EPITHELIUM; INTESTINE TUMOR; MALE; MESENCHYME; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; UPREGULATION; ANIMAL; COLON TUMOR; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; INTESTINE MUCOSA; METABOLISM; SMALL INTESTINE;

ANIMALS; ANTIGENS, NEOPLASM; COLON; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; INTESTINES; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES;

EID: 84892405056     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079359     Document Type: Article

References (31)

1. Togawa K, Yan YX, Inomoto T, Slaugenhaupt S, Rustgi AK (2000) Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. J Cell Physiol 183: 129-139.
2. Abe S, Yagi T, Ishiyama S, Hiroe M, Marumo F, et al. (1995) Molecular cloning of a novel serine/threonine kinase, MRK, possibly involved in cardiac development. Oncogene 11: 2187-2195.
3. Matsushime H, Jinno A, Takagi N, Shibuya M (1990) A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Mol Cell Biol 10: 2261-2268.
4. Bladt F, Birchmeier C (1993) Characterization and expression analysis of the murine rck gene: a protein kinase with a potential function in sensory cells. Differentiation 53: 115-122.
5. Miyata Y, Akashi M, Nishida E (1999) Molecular cloning and characterization of a novel member of the MAP kinase superfamily. Genes Cells 4: 299-309.
6. Miyata Y, Nishida E (1999) Distantly related cousins of MAP kinase: biochemical properties and possible physiological functions. Biochem Biophys Res Commun 266: 291-295.
7. Jinno A, Tanaka K, Matsushime H, Haneji T, Shibuya M (1993) Testis-specific mak protein kinase is expressed specifically in the meiotic phase in spermatogenesis and is associated with a 210-kilodalton cellular phosphoprotein. Mol Cell Biol 13: 4146-4156.
8. Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, et al. (2006) Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells. Cancer Res 66: 8439-8447.
9. Omori Y, Chaya T, Katoh K, Kajimura N, Sato S, et al. (2010) Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc Natl Acad Sci U S A 107: 22671-22676.
10. Uesaka T, Kageyama N (2004) Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. FEBS Lett 573: 147-154.
11. Fu Z, Schroeder MJ, Shabanowitz J, Kaldis P, Togawa K, et al. (2005) Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase. Mol Cell Biol 25: 6047-6064.
12. Wang LY, Kung HJ (2011) Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1). Oncogene.
13. Fu Z, Larson KA, Chitta RK, Parker SA, Turk BE, et al. (2006) Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. Mol Cell Biol 26: 8639-8654.
14. Lahiry P, Wang J, Robinson JF, Turowec JP, Litchfield DW, et al. (2009) A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. Am J Hum Genet 84: 134-147.
15. Ozgul RK, Siemiatkowska AM, Yucel D, Myers CA, Collin RW, et al. (2011) Exome sequencing and cis-regulatory mapping identify mutations in MAK, a gene encoding a regulator of ciliary length, as a cause of retinitis pigmentosa. Am J Hum Genet 89: 253-264.
16. Tucker BA, Scheetz TE, Mullins RF, DeLuca AP, Hoffmann JM, et al. (2011) Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa. Proc Natl Acad Sci U S A 108: E569-576.
17. Fu Z, Kim J, Vidrich A, Sturgill TW, Cohn SM (2009) Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 297: G632-640.
18. Sweetser DA, Birkenmeier EH, Hoppe PC, McKeel DW, Gordon JI (1988) Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes. Genes Dev 2: 1318-1332.
19. Whitehead RH, Demmler K, Rockman SP, Watson NK (1999) Clonogenic growth of epithelial cells from normal colonic mucosa from both mice and humans. Gastroenterology 117: 858-865.
20. Shinkai Y, Satoh H, Takeda N, Fukuda M, Chiba E, et al. (2002) A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation. Mol Cell Biol 22: 3276-3280.
21. Yan KS, Chia LA, Li X, Ootani A, Su J, et al. (2012) The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc Natl Acad Sci U S A 109: 466-471.
22. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007.
23. Sangiorgi E, Capecchi MR (2008) Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 40: 915-920.
24. Sturgill TW, Stoddard PB, Cohn SM, Mayo MW (2010) The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. Mol Cancer 9: 104.
25. Oving IM, Clevers HC (2002) Molecular causes of colon cancer. Eur J Clin Invest 32: 448-457.
26. Lehner F, Kulik U, Klempnauer J, Borlak J (2010) Inhibition of the liver enriched protein FOXA2 recovers HNF6 activity in human colon carcinoma and liver hepatoma cells. PLoS One 5: e13344.
27. Lehner F, Kulik U, Klempnauer J, Borlak J (2007) The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases. FASEB J 21: 1445-1462.
28. McCart AE, Vickaryous NK, Silver A (2008) Apc mice: models, modifiers and mutants. Pathol Res Pract 204: 479-490.
29. Jenkins AP, Thompson RP (1994) Enteral nutrition and the small intestine. Gut 35: 1765-1769.
30. Lenaerts K, Sokolovic M, Bouwman FG, Lamers WH, Mariman EC, et al. (2006) Starvation induces phase-specific changes in the proteome of mouse small intestine. J Proteome Res 5: 2113-2122.
31. Raul F, Schleiffer R (1996) Intestinal adaptation to nutritional stress. Proc Nutr Soc 55: 279-289.