Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Nakano, Masayuki ^a   Nakashima, Akio ^a   Nagano, Taiki ^a   Ishikawa, Shintaro ^b   Kikkawa, Ushio ^a   Kamada, Shinji ^a  

^a KOBE UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BLEOMYCIN; BRANCHED CHAIN AMINO ACID; ETOPOSIDE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN P21; RAPAMYCIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CANCER CELL; CELL AGING; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; UPREGULATION; DRUG EFFECTS; GENETICS; METABOLISM; TUMOR CELL LINE;

AMINO ACIDS, BRANCHED-CHAIN; CELL AGING; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; TOR SERINE-THREONINE KINASES;

EID: 84892398847     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080411     Document Type: Article

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