Survivin-3B promotes chemoresistance and immune escape by inhibiting caspase-8 and -6 in cancer cells

OncoImmunology

Volumn 2, Issue 11, 2013, Pages

  Végran, Frédérique ^a   Boidot, Romain ^b  

^a Chu   (France)

^b CENTRE GEORGES FRANÇOIS LECLERC   (France)

Author keywords

Caspase 6; Caspase 8; Survivin 3B; Treatment response; Tumor escape; Tumorigenesis

Indexed keywords

CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CISPLATIN; FAS ANTIGEN; FAS LIGAND; FLUOROURACIL; SMALL INTERFERING RNA; STAUROSPORINE; SURVIVIN; SURVIVIN 3B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER RESISTANCE; CARCINOGENESIS; DRUG TARGETING; GENE ACTIVITY; GENE FUNCTION; GENE INTERACTION; GENE OVEREXPRESSION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NATURAL KILLER CELL; NONHUMAN; SIGNAL TRANSDUCTION; TUMOR ESCAPE;

EID: 84892382184     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.26328     Document Type: Article

References (7)

1. Végran F, Mary R, Gibeaud A, Mirjolet C, Collin B, Oudot A, Charon-Barra C, Arnould L, Lizard-Nacol S, Boidot R. Survivin-3B potentiates immune escape in cancer but also inhibits the toxicity of cancer chemotherapy. Forthcoming. doi:10.1158/0008-5472CAN-13-0036.
2. Badran A, Yoshida A, Ishikawa K, Goi T, Yamaguchi A, Ueda T, Inuzuka M. Identification of a novel splice variant of the human anti-apoptopsis gene survivin. Biochem Biophys Res Commun 2004; 314:902-7; PMID:14741722; http://dx.doi.org/10.1016/j. bbrc.2003.12.178.
3. Knauer SK, Bier C, Schlag P, Fritzmann J, Dietmaier W, Rödel F, Klein-Hitpass L, Kovács AF, Döring C, Hansmann ML, et al. The survivin isoform survivin-3B is cytoprotective and can function as a chromosomal passenger complex protein. Cell Cycle 2007; 6:1502-9; PMID:17582222; http://dx.doi. org/10.4161/cc.6.12.4305.
4. Sawai K, Goi T, Hirono Y, Katayama K, Yamaguchi A. Survivin-3B gene decreases the invasion-inhibitory effect of colon cancer cells with 5-fluorouracil. Oncol Res 2010; 18:541-7; PMID:20939430; http://dx.doi. org/10.3727/096504010X12767359113848.
5. Fregni G, Perier A, Avril MF, Caignard A. NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies. Oncoimmunology 2012; 1:38-47; PMID:22720210; http://dx.doi.org/10.4161/onci.1.1.18312.
6. Boidot R, Végran F, Lizard-Nacol S. Predictive value of survivin alternative transcript expression in locally advanced breast cancer patients treated with neoadjuvant chemotherapy. Int J Mol Med 2009; 23:285-91; PMID:19148555.
7. Végran F, Boidot R, Bonnetain F, Cadouot M, Chevrier S, Lizard-Nacol S. Apoptosis gene signature of Survivin and its splice variant expression in breast carcinoma. Endocr Relat Cancer 2011; 18:783-92; PMID:21878572; http://dx.doi.org/10.1530/ERC-11-0105.