Hepatoprotective and antioxidant activity of pentagamavunon-0 against carbon tetrachloride-induced hepatic injury in rats

Asian Pacific Journal of Tropical Medicine

Volumn 6, Issue 6, 2013, Pages 438-442

  Nurrochmad, Arief ^a   Margono, Supardjan Amir ^a   Sardjiman, ^a   Hakim, Arief Rahman ^a   Ernawati, ^a   Kurniawati, Erna ^a   Fatmawati, Erva ^a  

^a GADJAH MADA UNIVERSITY   (Indonesia)

Author keywords

Antioxidant; Carbon tetrachloride; Hepatoprotective; Pentagamavunon 0; Rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BILIRUBIN; CARBON TETRACHLORIDE; CATALASE; CURCUMIN; GLUTATHIONE; LIVER PROTECTIVE AGENT; PENTAGAMAVUNON 0; SCAVENGER; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE POISONING; CATALASE; CURCUMIN; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; MALE; NITRIC OXIDE; RATS; RATS, WISTAR;

EID: 84892377018     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(13)60070-X     Document Type: Article

References (20)

1. Reed S Essential physiological biochemistry: An organ-based approach 2009, 172-228. A John Wiley & Sons Ltd, Chichester.
2. Fry M Essential biochemistry for medicine 2010, 91-105. John Wiley & Sons Ltd, Chichester.
3. Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harik-umar KB, Sung B, et al. Biological activities of curcumin and its analogues (Congeners) made by man and mother nature. Biochem Pharmacol 2008, 76:1590-1611.
4. Aggarwal BB, Harikumar KB Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009, 41:40-59.
5. Park EJ, Jeon CH, Ko G, Kim J, Sohn DH Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. J Pharm Pharmacol 2000, 52:437-440.
6. 4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol 2008, 73:399-409.
7. Kaur G, Tirkey N, Bharrhan S, Chanana V, Rishi P, Chopra K Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin Exp Immunol 2006, 145:313-321.
8. Shapiro H, Ashkenazi M, Weizman N, Shahmurov M, Aeed H, Bruck R Curcumin ameliorates acute thioacetamide-induced hepatotoxicity. J Gastroenterol Hepatol 2006, 21:358-366.
9. Sardjiman Synthesis of some new series of curcumin analogues, antioxidative, anti-inflammatory, antibacterial activities and qualitative structure-activity relationships. Dissertation submitted to 2000, Gadjah Mada University, Yogyakarta.
10. 4 in mice. J Appl Toxicol 2006, 26:326-332.
11. Muriel P Some experimental models of liver damage. Hepatotoxicity: from genomics to in vitro and in vivo models 2007, 119-130. John Wiley & Sons Ltd, Chichester. S.C. Sahu (Ed.).
12. Weber LWD, Boll M, Stampfl A Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003, 33:105-136.
13. Ellman GL Tissue sulfhydryl groups. Arch Biochem Biophys 1959, 82:70-77.
14. Aebi H Catalase. Methods in enzymatic analysis 1974, 674-684. Acadamic Press, New York. H.V. Bergmeyer (Ed.).
15. Fiedman LS, Keefe EB Handbook of liver diseases 2004, 1-16. Churchill Livingstone, Philadelphia. 2nd ed.
16. Nurrochmad A, Hakim AR, Supardjan AM, Sardjiman, Yuniarti N Evaluation of hepatoprotective and antioxidant activity of hexagamavunon-1 against carbon tetrachloride-induced hepatic injury in rats. Int J Pharmacy Pharm Sci 2010, 2:45-48.
17. Apte U, Krishnamurthy P Detoxification function of the liver. Molecular pathology of liver diseases 2010, 147-165. Springer, New York. S.P.S. Monga (Ed.).
18. Hewawasam RP, Jayatilaka KAPW, Pathirana C, Mudduwa LKB Hepatoprotective effect of Epaltes divaricata extract on carbon tetrachloride induced hepatotoxicity in mice. Indian J Med Res 2004, 120:30-34.
19. Yapar V, Kart A, Karapehlivan M, Atakisi O, Tuncac R, Erginsoy S, et al. Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. Exp Toxicol Pathol 2007, 59:121-128.
20. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC Multiple biological activities of curcumin: a short review. Life Sci 2006, 78:2081-2087.