Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathway

Human Immunology

Volumn 75, Issue 2, 2014, Pages 134-140

  Kankkunen, Päivi ^a   Välimäki, Elina ^a,b   Rintahaka, Johanna ^a,c   Palomäki, Jaana ^a   Nyman, Tuula ^a,b   Alenius, Harri ^a   Wolff, Henrik ^a   Matikainen, Sampsa ^a  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CBL PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; PROTEIN TYROSINE KINASE; PURINERGIC P2X7 RECEPTOR; RORIDIN A; SMALL INTERFERING RNA; SRC TYROSINE KINASE; UNCLASSIFIED DRUG; CARRIER PROTEIN; NLRP3 PROTEIN, HUMAN; TRICHOTHECENE DERIVATIVE;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; MACROPHAGE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN ACTIVATION; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; SIGNAL TRANSDUCTION; CELL CULTURE; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; UPREGULATION;

CARRIER PROTEINS; CELLS, CULTURED; HUMANS; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; MACROPHAGES; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTORS, PURINERGIC P2X7; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TRICHOTHECENES; UP-REGULATION;

EID: 84892368272     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.11.010     Document Type: Article

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