Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Sekihara, Kazumasa ^a   Harashima, Nanae ^a   Tongu, Miki ^b   Tamaki, Yukihisa ^a   Uchida, Nobue ^c   Inomata, Taisuke ^a   Harada, Mamoru ^a  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b SHIMANE UNIVERSITY   (Japan)

^c Tottori Prefectural Central Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN D1; GENE EXPRESSION REGULATION, NEOPLASTIC; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYPERTHERMIA, INDUCED; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MYC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84892185056     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078772     Document Type: Article

References (42)

1. Jemal A, Siegel R, Ward E, Ward E, Hao Y, et al. (2009) Cancer statistics 2009. CA Cancer J Clin 59: 225-249.
2. Gleave ME, Bruchovsky N, Moore MJ, Venuer P (1999) Prostate cancer: 9. Treatment of advanced disease. Can Med Assoc J 160: 225-232. (Pubitemid 29060375)
3. Tso CL, McBride WH, Sun J, Patel B, Tsui KH, et al. (2000) Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells. Cancer J 6: 220-233.
4. Roigas J, Wallen ES, Moseley PL (1998) Effects of combined treatment of chemotherapeutics and hyperthermia on survival and the regulation of heat shock proteins in Dunning R3327 prostate carcinoma cells. Prostate 34: 195-202. (Pubitemid 28156610)
5. Kampinga HH, Dikomey E (2001) Hyperthermic radiosensitization: mode of action and clinical relevance. Int J Radiat Biol 77: 399-408. (Pubitemid 32281123)
6. Michalakis J, Georgatos SD, de Bree, Polioudaki H, Romanos J, et al. (2007) Short-term exposure of cancer cells to micromolar doses of paclitaxel, with or without hyperthermia, induces long-term inhibition of cell proliferation and cell death in vitro. Ann Surg Oncol 14: 1220-1228.
7. Overgaad J, Gonzales Gonzales D, Hulshof MC, Arcangeli G, Dahl O, et al. (1995) Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. European Society for Hyperthermic Oncology. Lancet 345: 540-543.
8. van der Zee J, González González D, van Rhoon GC, van Dijk JD, van Putten WL, et al. (2000) Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet 355: 1119-1125. (Pubitemid 30172932)
9. Jones EL, Oleson JR, Prosnitz LR, Samulski TV, Vujaskovic Z, et al. (2005) Randomized trial of hyperthermia and radiation for superficial tumors. J Clin Oncol 23: 3079-3085. (Pubitemid 46224131)
10. Colombo R, Da Pozzo LF, Salonia A, Rigatti P, Leib Z, et al. (2003) Multicentric study comparing intravesical chemotherapy alone and with local microwave hyperthermia for prophylaxis of recurrence of superficial transitional cell carcinoma. J Clin Oncol 21: 4270-4276. (Pubitemid 46621801)
11. Kouloulias V, Plataniotis G, Kouvaris J, Dardoufas C, Gennatas C, et al. (2005) Chemoradiotherapy combined with intracavitary hyperthermia for anal cancer: feasibility and long-term results from a phase II randomized trial. Am J Clin Oncol 28: 91-99. (Pubitemid 40209330)
12. Asea A, Ara G, Teicher BA, Stevenson MA, Calderwood SK (2001) Effects of the flavonoid drug Quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo. Int J Hyperthermia 17: 347-356. (Pubitemid 32651842)
13. Haveman J, Bergs JWJ, Franken NA, van Bree C, Stalpers LJ (2005) Effect of hyperthermia on uptake and cytotoxicity of cisplatin in cultured murine mammary carcinoma cells. Oncol Rep 14: 561-567.
14. Jäättelä M (1999) Escaping cell death: survival proteins in cancer. Exp Cell Res 248: 30-43.
15. Beere HM (2004) "The stress of dying": the role of heat shock proteins in the regulation of apoptosis. J Cell Sci 117: 2641-2651.
16. Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, et al. (2001) Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 3: 839-843. (Pubitemid 32842690)
17. Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, et al. (2007) Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell 131: 257-270. (Pubitemid 47576138)
18. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY (1998) Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett 438: 1-4. (Pubitemid 28517824)
19. Galluzzi L, Giordanetto F, Kroemer G (2009) Targeting HSP70 for cancer therapy. Molecular Cell 36: 176-177.
20. Mayer MP, Bukau B (2005) Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 62: 670-84.
21. Daugaard M, Rohde M, Jäättelä M (2007) The heat shock protein 70 family: highly homologous proteins with overlapping and distinct functions. FEBS Lett 581: 3702-3710. (Pubitemid 47081009)
22. Gress TM, Muller-Pillasch F, Weber C, Lerch MM, Friess H, et al. (1994) Differential expression of heat shock proteins in pancreatic carcinoma. Cancer Res 54: 547-551. (Pubitemid 24053199)
23. Mylandsted J, Brands K, Jäättelä M (2000) Heat shock protein 70 is required for the survival of cancer cells. Ann N Y Acad Sci 926: 122-125.
24. Nylandsted J, Wick W, Hirt UA, Brand K, Rohde M, et al. (2002) Eradication of glioblastoma and breast and colon carcinoma xenografts by Hsp70 depletion. Cancer Res 62: 7139-7142. (Pubitemid 36025225)
25. Rohde M, Daugaard M, Jensen MH, Helin K, Nylandsted J, et al. (2005) Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev 19: 570-582. (Pubitemid 40314989)
26. Schmitt E, Maingret L, Puig PE, Rerole AL, Ghiringhelli F, et al. (2006) Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma. Cancer Res 66: 4191-4197.
27. Aghdassi A, Phillips P, Dudeja V, Dhaulakhandi D, Sharif R, et al. (2007) Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma. Cancer Res 67: 616-625. (Pubitemid 46192200)
28. Powers MV, Clarke PA, Workman P (2008) Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell 14: 250-262.
29. Strom E, Sathe S, Komarov PG, Chernova OB, Pavlovska I, et al. (2006) Small-moleculae inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol 2: 474-479. (Pubitemid 44266309)
30. Leu JI, Pimkina J, Frank A, Murphy ME, George DL (2009) A Small Molecule Inhibitor of Inducible Heat Shock Protein 70. Molecular Cell 36: 15-27.
31. Nagai N, Nakai A, Nagata K (1995) Quercetin suppress heat shock response by down regulation of HSF1. Biochem Biophys Res Commun 208: 1099-1105.
32. Monma H, Harashima N, Inao T, Okano S, Tajima Y, et al. (2013) The HSP70 and autophagy inhibitor pifithrin-μ enhances the antitumor effects of TRAIL on human pancreatic cancer. Molecular Cancer Therapeutics 12: 341-351.
33. Kalapurakal A, Pierce M, Chen A, Sathiaseelan V (2003) Efficacy of irradiation and external hyperthermia in locally advanced, hormone-refractory or radiation recurrent prostate cancer: a preliminary report. Int J Radiat Oncol Biol Phys 57: 654-664. (Pubitemid 37194291)
34. Dudeja V, Mujumdar N, Phillips P, Chugh R, Borja-Cacho D, et al. (2009) Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. Gastroenterology 136: 1772-1782.
35. Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, et al (2013) A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res 11: 219-229.
36. Murphy ME (2013) The HSP70 family and cancer. Carcinogenesis 34: 1181-1188.
37. Banerji U, O'Donnell A, Scurr M, Pacey S, Stapleton S, et al. (2005) Phase I pharmacokinetic and pharmacodynamics study of 17-allylamine, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 23: 4152-4161. (Pubitemid 46211321)
38. Davenport EL, Zeisig A, Aronson LI, Moore HE, Hockley S, et al. (2010) Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma. Leukemia 24: 1804-1807.
39. Morishima Y, Murphy PJ, Li DP, Sanchez ER, Pratt WB (2000) Stepwide assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket. J Biol Chem 66: 535-545.
40. Leu JI, Pimkina J, Pandey P, Murphy ME, George DL (2011) HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res 9: 936-947.
41. Cabde C, Vahsen N, arrido C, Kroemer G (2004) Apoptosis-inducing factor (AIF): caspase-independent after all. Cell Death Differentiation 11: 591-595.
42. Nylandsted J, Gyrd-Hansen M, Danielewicz A, Fehrenbacher N, Lademann U, et al. (2004) Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 200: 425-435. (Pubitemid 39121900)