Screening entire health system ecg databases to identify patients at increased risk of death

Circulation: Arrhythmia and Electrophysiology

Volumn 6, Issue 6, 2013, Pages 1156-1162

  Strauss, David G ^a   Mewton, Nathan ^b   Verrier, Richard L ^c   Nearing, Bruce D ^c   Marchlinski, Francis E ^d   Killian, Tony ^d   Moxley, John ^b   Tereshchenko, Larisa G ^b   Wu, Katherine C ^b   Winslow, Raimond ^e   Cox, Christopher ^f   Spooner, Peter M ^b   Lima, João A C ^b  

^a CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^e Johns Hopkins University   (United States)

^f JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Arrhythmias; Cardiac; Death; Electrocardiography; Fibrosis; Mass screening

Indexed keywords

ADULT; AGE; AGED; ARTICLE; CARDIAC PATIENT; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DEATH; ELECTROCARDIOGRAM; FEMALE; HEART ATRIUM FIBRILLATION; HEART DEPOLARIZATION; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART RATE; HEART REPOLARIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT IDENTIFICATION; PRIORITY JOURNAL; QRS COMPLEX; SCREENING; SEX;

EID: 84892160346     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.113.000411     Document Type: Article

References (24)

1. Goldberger JJ, Cain ME, Hohnloser SH, Kadish AH, Knight BP, Lauer MS, Maron BJ, Page RL, Passman RS, Siscovick D, Stevenson WG, Zipes DP. American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death. Circulation. 2008;118:1497-1518.
2. Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. N Engl J Med. 2001;345:1473-1482.
3. Strauss DG, Selvester RH, Lima JA, Arheden H, Miller JM, Gerstenblith G, Marbán E, Weiss RG, Tomaselli GF, Wagner GS, Wu KC. ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: Correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol. 2008;1:327-336.
4. Strauss DG, Cardoso S, Lima JA, Rochitte CE, Wu KC. ECG scar quantification correlates with cardiac magnetic resonance scar size and prognostic factors in Chagas' disease. Heart. 2011;97:357-361.
5. Strauss DG, Poole JE, Wagner GS, Selvester RH, Miller JM, Anderson J, Johnson G, McNulty SE, Mark DB, Lee KL, Bardy GH, Wu KC. An ECG index of myocardial scar enhances prediction of defibrillator shocks: An analysis of the Sudden Cardiac Death in Heart Failure Trial. Heart Rhythm. 2011;8:38-45.
6. Tjandrawidjaja MC, Fu Y, Westerhout CM, Wagner GS, Granger CB, Armstrong PW; APEX-AMI Investigators. Usefulness of the QRS score as a strong prognostic marker in patients discharged after undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Am J Cardiol. 2010;106:630-634.
7. Richardson K, Engel G, Yamazaki T, Chun S, Froelicher VF. Electrocardiographic damage scores and cardiovascular mortality. Am Heart J. 2005;149:458-463.
8. Borleffs CJ, Scherptong RW, Man SC, van Welsenes GH, Bax JJ, van Erven L, Swenne CA, Schalij MJ. Predicting ventricular arrhythmias in patients with ischemic heart disease: Clinical application of the ECGderived QRS-T angle. Circ Arrhythm Electrophysiol. 2009;2:548-554.
9. Kardys I, Kors JA, van der Meer IM, Hofman A, van der Kuip DA, Witteman JC. Spatial QRS-T angle predicts cardiac death in a general population. Eur Heart J. 2003;24:1357-1364.
10. Yamazaki T, Froelicher VF, Myers J, Chun S, Wang P. Spatial QRS-T angle predicts cardiac death in a clinical population. Heart Rhythm. 2005;2:73-78.
11. Kors JA, van Herpen G, Sittig AC, van Bemmel JH. Reconstruction of the Frank vectorcardiogram from standard electrocardiographic leads: Diagnostic comparison of different methods. Eur Heart J. 1990;11:1083-1092.
12. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145:247-254.
13. Strauss DG, Wu KC. Imaging myocardial scar and arrhythmic risk prediction-a role for the electrocardiogram? J Electrocardiol. 2009;42:138 e131-138.
14. Schmidt A, Azevedo CF, Cheng A, Gupta SN, Bluemke DA, Foo TK, Gerstenblith G, Weiss RG, Marbán E, Tomaselli GF, Lima JA, Wu KC. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation. 2007;115:2006-2014.
15. Yan AT, Shayne AJ, Brown KA, Gupta SN, Chan CW, Luu TM, Di Carli MF, Reynolds HG, Stevenson WG, Kwong RY. Characterization of the peri-infarct zone by contrast-enhanced cardiac magnetic resonance imaging is a powerful predictor of post-myocardial infarction mortality. Circulation. 2006;114:32-39.
16. Roes SD, Borleffs CJ, van der Geest RJ, Westenberg JJ, Marsan NA, Kaandorp TA, Reiber JH, Zeppenfeld K, Lamb HJ, de Roos A, Schalij MJ, Bax JJ. Infarct tissue heterogeneity assessed with contrast-enhanced MRI predicts spontaneous ventricular arrhythmia in patients with ischemic cardiomyopathy and implantable cardioverter-defibrillator. Circ Cardiovasc Imaging. 2009;2:183-190.
17. Fox KM, Ferrari R. Heart rate: A forgotten link in coronary artery disease? Nat Rev Cardiol. 2011;8:369-379.
18. Verrier RL, Tan A. Heart rate, autonomic markers, and cardiac mortality. Heart Rhythm. 2009;6(suppl 11):S68-S75.
19. Pun PH, Smarz TR, Honeycutt EF, Shaw LK, Al-Khatib SM, Middleton JP. Chronic kidney disease is associated with increased risk of sudden cardiac death among patients with coronary artery disease. Kidney Int. 2009;76:652-658.
20. Shamseddin MK, Parfrey PS. Sudden cardiac death in chronic kidney disease: Epidemiology and prevention. Nat Rev Nephrol. 2011;7:145-154.
21. Goldberger JJ, Buxton AE, Cain M, Costantini O, Exner DV, Knight BP, Lloyd-Jones D, Kadish AH, Lee B, Moss A, Myerburg R, Olgin J, Passman R, Rosenbaum D, Stevenson W, Zareba W, Zipes DP. Risk stratification for arrhythmic sudden cardiac death: Identifying the roadblocks. Circulation. 2011;123:2423-2430.
22. Braunwald E. Biomarkers in heart failure. N Engl J Med. 2008;358:2148-2159.
23. Verrier RL, Klingenheben T, Malik M, El-Sherif N, Exner DV, Hohnloser SH, Ikeda T, Martínez JP, Narayan SM, Nieminen T, Rosenbaum DS. Microvolt T-wave alternans testing has a role in arrhythmia risk stratification. J Am Coll Cardiol. 2012;59:1572-1573.
24. Hermansen SW, Leitzmann MF, Schatzkin A. The impact on National Death Index ascertainment of limiting submissions to Social Security Administration Death Master File matches in epidemiologic studies of mortality. Am J Epidemiol. 2009;169:901-908.