-
1
-
-
84856994155
-
Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy
-
Sun D, Tainsky MA, Haddad R. Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy. Transl Oncologenomics 2012;5:1-7.
-
(2012)
Transl Oncologenomics
, vol.5
, pp. 1-7
-
-
Sun, D.1
Tainsky, M.A.2
Haddad, R.3
-
2
-
-
64549151639
-
Germline and somatic NF1 mutations in sporadic and NF-1 associated malignant nerve sheath tumors
-
Bottillo I, Ahlquist T, Brekke H, et al. Germline and somatic NF1 mutations in sporadic and NF-1 associated malignant nerve sheath tumors. J Pathol 2009;217:693-701.
-
(2009)
J Pathol
, vol.217
, pp. 693-701
-
-
Bottillo, I.1
Ahlquist, T.2
Brekke, H.3
-
3
-
-
84873809147
-
MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
-
Jessen WJ, Miller SJ, Jousma E, et al. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. J Clin Invest 2013;123:340-347.
-
(2013)
J Clin Invest
, vol.123
, pp. 340-347
-
-
Jessen, W.J.1
Miller, S.J.2
Jousma, E.3
-
4
-
-
42249087305
-
Sorafenib inhibits growth and MAPK signaling in malignant peripheral nerve sheath cells
-
Ambrosini G, Cheema HS, Seetman S, et al. Sorafenib inhibits growth and MAPK signaling in malignant peripheral nerve sheath cells. Mol Cancer Ther 2012;7:890-896.
-
(2012)
Mol Cancer Ther
, vol.7
, pp. 890-896
-
-
Ambrosini, G.1
Cheema, H.S.2
Seetman, S.3
-
5
-
-
77955602211
-
Gatekeeper mutations mediate resistance to BRAF-targeted therapies
-
Whittaker S, Kirk R, Hayward R, et al. Gatekeeper mutations mediate resistance to BRAF-targeted therapies. Sci Transl Med 2010;2:35ra41.
-
(2010)
Sci Transl Med
, vol.2
-
-
Whittaker, S.1
Kirk, R.2
Hayward, R.3
-
6
-
-
67650293850
-
Phase II study of sorafenib in patients with metastatic or recurrent sarcomas
-
Maki RG, D'Adamo DR, Keohan ML, et al. Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol 2009;27:3133-3140.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3133-3140
-
-
Maki, R.G.1
D'Adamo, D.R.2
Keohan, M.L.3
-
7
-
-
79959293462
-
BRAF mutations in hairy cell leukemia
-
Tiacci E, Frifonov V, Schiavoni G, et al. BRAF mutations in hairy cell leukemia. N Engl J Med 2011;364:2305-2315.
-
(2011)
N Engl J Med
, vol.364
, pp. 2305-2315
-
-
Tiacci, E.1
Frifonov, V.2
Schiavoni, G.3
-
8
-
-
84872650338
-
BRAF V600E and KRAS G12S mutations in peripheral nerve sheath tumors
-
Serrano C, Simonetti S, Hernandez-Losa J, et al. BRAF V600E and KRAS G12S mutations in peripheral nerve sheath tumors. Histopathology 2013;62:499-504.
-
(2013)
Histopathology
, vol.62
, pp. 499-504
-
-
Serrano, C.1
Simonetti, S.2
Hernandez-Losa, J.3
-
9
-
-
85042692200
-
BRAF V600E mutations in benign and malignant nerve sheath tumors
-
[abstract]. Abstract 10043
-
Serrano C, Simonetti S, Hernandez J, et al. BRAF V600E mutations in benign and malignant nerve sheath tumors [abstract]. J Clin Oncol 2010;28(Suppl 15):Abstract 10043.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL. 15
-
-
Serrano, C.1
Simonetti, S.2
Hernandez, J.3
-
10
-
-
79954441895
-
Analysis of BRAF v600e mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma, and extra-cerebellar pilocytic astrocytoma
-
Schindler G, Capper D, Meyer J, et al. Analysis of BRAF v600e mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma, and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 2011;121:397-405.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 397-405
-
-
Schindler, G.1
Capper, D.2
Meyer, J.3
-
11
-
-
1442323605
-
BRAF mutations are common somatic events in melanocytic nevi
-
Kumar R, Angelini S, Snellman E, et al. BRAF mutations are common somatic events in melanocytic nevi. J Invest Dermatol 2004;122:342-348.
-
(2004)
J Invest Dermatol
, vol.122
, pp. 342-348
-
-
Kumar, R.1
Angelini, S.2
Snellman, E.3
-
12
-
-
78649723255
-
PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors
-
[abstract]. Abstract 3534
-
Kopetz S, Desai J, Chan E, et al. PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors [abstract]. J Clin Oncol 2010;28(15 Suppl):Abstract 3534.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Kopetz, S.1
Desai, J.2
Chan, E.3
-
13
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild HA, Haanen RC, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-2516.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, H.A.2
Haanen, R.C.3
-
14
-
-
84877600792
-
Déjà vu: EGF receptors drive resistance to BRAF inhibitors
-
Girotti M, Marais R. Déjà vu: EGF receptors drive resistance to BRAF inhibitors. Cancer Discov 2013;3:487-590.
-
(2013)
Cancer Discov
, vol.3
, pp. 487-590
-
-
Girotti, M.1
Marais, R.2
-
15
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen JP, Mermel C, Zejnullah K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008;14:4275-4283.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullah, K.3
-
16
-
-
78650303507
-
Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi H, Wang Q, et al. Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation. Nature 2010;468:973-977.
-
(2010)
Nature
, vol.468
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
-
17
-
-
84879496934
-
Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma
-
Trunzer K, Pavlick AC, Schuchter L, et al. Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. J Clin Oncol 2013;31:1767-1774.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1767-1774
-
-
Trunzer, K.1
Pavlick, A.C.2
Schuchter, L.3
-
18
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT, Jeffrey R, Infante JR, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367:1694-1703.
-
(2012)
N Engl J Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Jeffrey, R.2
Infante, J.R.3
-
19
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF (V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF (V600E) inhibition through feedback activation of EGFR. Nature 2012;483:101-104.
-
(2012)
Nature
, vol.483
, pp. 101-104
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
-
20
-
-
84873360893
-
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents
-
Mao M, Tian F, Mariadason JM, et al. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res 2013;19:657-667.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 657-667
-
-
Mao, M.1
Tian, F.2
Mariadason, J.M.3
-
21
-
-
84877631604
-
Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas
-
Montero-Conde C, Ruiz-Llorente S, Dominguez JM, et al. Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas. Cancer Discov 2013;3:520-533.
-
(2013)
Cancer Discov
, vol.3
, pp. 520-533
-
-
Montero-Conde, C.1
Ruiz-Llorente, S.2
Dominguez, J.M.3
-
22
-
-
0034102193
-
Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models
-
DeClue JE, Heffelfinger S, Benvenuto G, et al. Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models. J Clin Invest 2000;105:1233-1241.
-
(2000)
J Clin Invest
, vol.105
, pp. 1233-1241
-
-
DeClue, J.E.1
Heffelfinger, S.2
Benvenuto, G.3
-
23
-
-
66849131261
-
Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor
-
Zou CY, Smith KD, Zhu QS, et al. Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther 2009;8:1157-1168.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1157-1168
-
-
Zou, C.Y.1
Smith, K.D.2
Zhu, Q.S.3
-
24
-
-
84864285936
-
BRAF inhibition and beyond in advanced melanoma
-
Margolin K. BRAF inhibition and beyond in advanced melanoma. Lancet 2012;380:320-322.
-
(2012)
Lancet
, vol.380
, pp. 320-322
-
-
Margolin, K.1
-
25
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E)
-
Poulikakos PI, Persaud Y, Janakiraman MJ, et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E). Nature 2011;480:387-390.
-
(2011)
Nature
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
Janakiraman, M.J.3
-
26
-
-
77954218212
-
BRAF as therapeutic target in melanoma
-
Wellbrock C, Hurlstone A. BRAF as therapeutic target in melanoma. Biochem Pharmacol 2010;80:561-567.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 561-567
-
-
Wellbrock, C.1
Hurlstone, A.2
|