Effect of fesoterodine in vulnerable elderly subjects with urgency incontinence: A double-blind, placebo controlled trial

Journal of Urology

Volumn 191, Issue 2, 2014, Pages 395-404

  Dubeau, Catherine E ^a   Kraus, Stephen R ^b   Griebling, Tomas L ^c   Newman, Diane K ^d   Wyman, Jean F ^e   Johnson II, Theodore M ^f   Ouslander, Joseph G ^g   Sun, Franklin ^h   Gong, Jason ^h   Bavendam, Tamara ^h  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c UNIVERSITY OF KANSAS   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f ATLANTA VA MEDICAL CENTER   (United States)

^g FLORIDA ATLANTIC UNIVERSITY   (United States)

^h PFIZER INC   (United States)

Author keywords

fesoterodine; muscarinic antagonists; overactive; urge; urinary bladder; urinary incontinence; vulnerable populations

Indexed keywords

FESOTERODINE; PLACEBO;

AGED; ARTHRALGIA; ARTICLE; BACKACHE; BLURRED VISION; BRONCHITIS; COMORBIDITY; CONFUSION; CONSTIPATION; CONTROLLED STUDY; CONTUSION; COPING BEHAVIOR; COUGHING; DIARRHEA; DIASTOLIC BLOOD PRESSURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRY EYE; DRY THROAT; DYSPEPSIA; DYSURIA; FALLING; FATIGUE; FEMALE; FUNCTIONAL DISEASE; GASTROESOPHAGEAL REFLUX; GERIATRIC DISORDER; HEADACHE; HEART PALPITATION; HUMAN; HYPERTENSION; INFLUENZA; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MINI MENTAL STATE EXAMINATION; MUSCLE SPASM; NAUSEA; OUTCOME ASSESSMENT; OVERACTIVE BLADDER QUESTIONNAIRE; PERIPHERAL EDEMA; POLYPHARMACY; POSTVOID RESIDUAL URINE VOLUME; PRIORITY JOURNAL; PRURITUS; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RASH; RESTING HEART RATE; RHINOPHARYNGITIS; SELF REPORT; SINUSITIS; SOMNOLENCE; SYSTOLIC BLOOD PRESSURE; UPPER ABDOMINAL PAIN; UPPER RESPIRATORY TRACT INFECTION; URGE INCONTINENCE; URINARY TRACT INFECTION; URINE RETENTION; URTICARIA; XEROSTOMIA; ADULT; ASSESSMENT OF HUMANS; COMPARATIVE STUDY; DEMOGRAPHY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG ERUPTION; DRUG WITHDRAWAL; MICTURITION; MULTICENTER STUDY; SENESCENCE; URINARY SENSATION SCALE; URINARY URGENCY; URINE INCONTINENCE;

ADVERSE EVENTS; AES; FESOTERODINE; HEALTH RELATED QUALITY OF LIFE; HRQL; MUSCARINIC ANTAGONISTS; OAB; OVERACTIVE; OVERACTIVE BLADDER; POST-VOID RESIDUAL URINARY VOLUME; PVR; URGE; URGENCY URINARY INCONTINENCE; URINARY BLADDER; URINARY INCONTINENCE; UUI; VE; VULNERABLE ELDERLY; VULNERABLE POPULATIONS;

AGED; AGED, 80 AND OVER; BENZHYDRYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MUSCARINIC ANTAGONISTS; URINARY INCONTINENCE, URGE; UROLOGICAL AGENTS; VULNERABLE POPULATIONS;

EID: 84891938444     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2013.08.027     Document Type: Article

References (30)

1. C.E. DuBeau, G.A. Kuchel, and T. Johnson 2nd et al. Incontinence in the frail elderly: report from the 4th International Consultation on Incontinence Neurourol Urodyn 29 2010 165
2. S. Hill, M. Elhilali, and R.J. Millard et al. Long-term darifenacin treatment for overactive bladder in patients aged 65 years and older: analysis of results from a 2-year, open-label extension study Curr Med Res Opin 23 2007 2697
3. N.R. Zinner, A. Mattiasson, and S.L. Stanton Efficacy, safety, and tolerability of extended-release once-daily tolterodine treatment for overactive bladder in older versus younger patients J Am Geriatr Soc 50 2002 799
4. S.R. Kraus, J.L. Ruiz-Cerdá, and D. Martire et al. Efficacy and tolerability of fesoterodine in older and younger subjects with overactive bladder Urology 76 2010 1350
5. P.K. Sand, T.M. Johnson II, and E.S. Rovner et al. Trospium chloride once-daily extended release is efficacious and tolerated in elderly subjects (aged ≥75 years) with overactive bladder syndrome BJU Int 107 2011 612
6. N. Zinner, L. Noe, and L. Rasouliyan et al. Impact of solifenacin on quality of life, medical care use, work productivity, and health utility in the elderly: an exploratory subgroup analysis Am J Geriatr Pharmacother 7 2009 373
7. J.P. Capo, V. Lucente, and S. Forero-Schwanhaeuser et al. Efficacy and tolerability of solifenacin in patients aged ≥65 years with overactive bladder: post-hoc analysis of 2 open-label studies Postgrad Med 123 2011 94
8. A. Wagg, J.J. Wyndaele, and P. Sieber Efficacy and tolerability of solifenacin in elderly subjects with overactive bladder syndrome: a pooled analysis Am J Geriatr Pharmacother 4 2006 14
9. C. Chapple, C. DuBeau, and U. Ebinger et al. Darifenacin treatment of patients >or= 65 years with overactive bladder: results of a randomized, controlled, 12-week trial Curr Med Res Opin 23 2007 2347
10. J.G. Malone-Lee, J.B. Walsh, and M.F. Maugourd Tolterodine: a safe and effective treatment for older patients with overactive bladder J Am Geriatr Soc 49 2001 700
11. A. Wagg, V. Khullar, and D. Marschall-Kehrel et al. Flexible-dose fesoterodine in elderly subjects with overactive bladder: results of the randomised, double-blind, placebo-controlled study of fesoterodine in an aging population trial J Am Geriatr Soc 61 2013 185
12. V.A. Minassian, S. Ross, and O. Sumabat et al. Randomized trial of oxybutynin extended versus immediate release for women aged 65 and older with overactive bladder: lessons learned from conducting a trial J Obstet Gynaecol Can 29 2007 726
13. P. Sand, N. Zinner, and D. Newman et al. Oxybutynin transdermal system improves the quality of life in adults with overactive bladder: a multicentre, community-based, randomized study BJU Int 99 2007 836
14. J.G. Ouslander, J. Blaustein, and A. Connor et al. Habit training and oxybutynin for incontinence in nursing home patients: a placebo-controlled trial J Am Geriatr Soc 36 1988 40
15. J.G. Ouslander, J.F. Schnelle, and G. Uman et al. Does oxybutynin add to the effectiveness of prompted voiding for urinary incontinence among nursing home residents? A placebo-controlled trial J Am Geriatr Soc 43 1995 610
16. M.L. Zorzitto, P.J. Holliday, and M.A. Jewett et al. Oxybutynin chloride for geriatric urinary dysfunction: a double-blind placebo-controlled study Age Ageing 18 1989 195
17. G. Szonyi, D.M. Collas, and Y.Y. Ding et al. Oxybutynin with bladder retraining for detrusor instability in elderly people: a randomized controlled trial Age Ageing 24 1995 287
18. World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. Available at www.wma.net/en/ 30publications/10policies/b3/. Accessed July 11, 2013.
19. International Conference on Harmonisation: Guidelines for good clinical practice. Available at www.ich.org/. Accessed July 11, 2013.
20. K.S. Coyne, L.S. Matza, and Z. Kopp et al. The validation of the Patient Perception of Bladder Condition (PPBC): a single-item global measure for patients with overactive bladder Eur Urol 49 2006 1079
21. D. Saliba, M. Elliott, and L.Z. Rubenstein et al. The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community J Am Geriatr Soc 49 2001 1691
22. K.S. Coyne, M.K. Margolis, and R. Hsieh et al. Validation of the urinary sensation scale (USS) Neurourol Urodyn 30 2011 360
23. M.F. Folstein, S.E. Folstein, and P.R. McHugh "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189
24. K. Coyne, D. Revicki, and T. Hunt et al. Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: the OAB-q Qual Life Res 11 2002 563
25. E. Piault, C.J. Evans, and D. Espindle et al. Development and validation of the Overactive Bladder Satisfaction (OAB-S) Questionnaire Neurourol Urodyn 27 2008 179
26. D. Podsiadlo, and S. Richardson The timed "Up & Go": a test of basic functional mobility for frail elderly persons J Am Geriatr Soc 39 1991 142
27. M.M. Weissman, D. Sholomskas, and M. Pottenger et al. Assessing depressive symptoms in five psychiatric populations: a validation study Am J Epidemiol 106 1977 203
28. C.E. Kelly Evaluation of voiding dysfunction and measurement of bladder volume Rev Urol 6 2004 S32
29. C. Dell'Utri, G.A. Digesu, and A. Bhide et al. Fesoterodine in randomised clinical trials: an updated systematic clinical review of efficacy and safety Int Urogynecol J 23 2012 1337
30. J. Malone-Lee, B. Shaffu, and C. Anand et al. Tolterodine: superior tolerability than and comparable efficacy to oxybutynin in individuals 50 years old or older with overactive bladder: a randomized controlled trial J Urol 165 2001 1452