Growth feedback as a basis for persister bistability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages 544-549

  Feng, Jingchen ^a   Kessler, David A ^b   Ben Jacob, Eshel ^a,c   Levine, Herbert ^a  

^a Rice University   (United States)

^b BAR ILAN UNIVERSITY   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; TOXIN;

ARTICLE; CELL GROWTH; ESCHERICHIA COLI; FEEDBACK SYSTEM; GROWTH CURVE; GROWTH RATE; NONHUMAN; OPERON; PRIORITY JOURNAL; PROMOTER REGION; SIMULATION; STOCHASTIC MODEL;

ALGORITHMS; ALLELES; ANTI-BACTERIAL AGENTS; ANTITOXINS; BACTERIAL TOXINS; BIOFILMS; COMPUTER SIMULATION; DNA-BINDING PROTEINS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENETIC VARIATION; MODELS, GENETIC; MONTE CARLO METHOD; PROMOTER REGIONS, GENETIC;

EID: 84891926324     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320396110     Document Type: Article

References (22)

1. Bigger JW (1944) Treatment of Staphylococcal infections with Penicillin by intermittent sterilisation. Lancet 244(6320): 497-500.
2. Chain EB, Duthie ES (1945) Bactericidal and bacteriolytic action of penicillin on the staphylococcus. Lancet 245(6352): 652-657.
3. Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S (2004) Bacterial persistence as a phenotypic switch. Science 305(5690): 1622-1625.
4. Moyed HS, Bertrand KP (1983) hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis. J Bacteriol 155(2): 768-775.
5. Hayes F (2003) Toxins-antitoxins: Plasmid maintenance, programmed cell death, and cell cycle arrest. Science 301(5639): 1496-1499.
6. Gerdes K, Christensen SK, Løbner-Olesen A (2005) Prokaryotic toxin-antitoxin stress response loci. Nat Rev Microbiol 3(5): 371-382.
7. Keren I, Shah D, Spoering A, Kaldalu N, Lewis K (2004) Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. J Bacteriol 186(24): 8172-8180.
8. Rotem E, et al. (2010) Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence. Proc Natl Acad Sci USA 107(28): 12541-12546.
9. Koh RS, Dunlop MJ (2012) Modeling suggests that gene circuit architecture controls phenotypic variability in a bacterial persistence network. BMC Syst Biol 6(1):47.
10. Lou C, Li Z, Ouyang Q (2008) A molecular model for persister in E. coli. J Theor Biol 255(2): 205-209.
11. Schumacher MA, et al. (2009) Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science 323(5912): 396-401.
12. Correia FF, et al. (2006) Kinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coli. J Bacteriol 188(24): 8360-8367.
13. Black DS, Irwin B, Moyed HS (1994) Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. J Bacteriol 176(13): 4081-4091.
14. Shah D, et al. (2006) Persisters: A distinct physiological state of E. coli. BMC Microbiol 6(1):53.
15. Gefen O, Balaban NQ (2009) The importance of being persistent: Heterogeneity of bacterial populations under antibiotic stress. FEMS Microbiol Rev 33(4): 704-717.
16. Hansen S, Lewis K, Vuli-c M (2008) Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Antimicrob Agents Chemother 52(8): 2718-2726.
17. Sivan P, Chana G, Roy K, Amos O, Balaban NQ (2008) Nongenetic individuality in the host-phage interaction. PLoS Biol 6(5): 957-964.
18. Black DS, Kelly AJ, Mardis MJ, Moyed HS (1991) Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. J Bacteriol 173(18): 5732-5739.
19. Korch SB, Henderson TA, Hill TM (2003) Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Mol Microbiol 50(4): 1199-1213.
20. Korch SB, Hill TM (2006) Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli: Effects on macromolecular synthesis and persister formation. J Bacteriol 188(11): 3826-3836.
21. Klumpp S, Zhang Z, Hwa T (2009) Growth rate-dependent global effects on gene expression in bacteria. Cell 139(7): 1366-1375.
22. Fasani RA, Savageau MA (2013) Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proc Natl Acad Sci USA 110(27): E2528-E2537.