Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGB44-PCDC4) as predictor of metastatic tumor potential

Epigenetics

Volumn 9, Issue 1, 2014, Pages 129-141

  Ferraro, Angelo ^a   Kontos, Christos K ^a,c   Boni, Themis ^a   Bantounas, Ioannis ^a,d   Siakouli, Dimitra ^a   Kosmidou, Vivian ^a   Vlassi, Margarita ^a   Spyridakis, Yannis ^b   Tsipras, Iraklis ^b   Zografos, George ^b   Pintzas, Alexander ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b G GENNIMATAS GENERAL HOSPITAL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Epithelial mesenchymal transition (EMT); Histone modifications; ITG 4; Metastasis markers; miR 21; RAS

Indexed keywords

BETA4 INTEGRIN; MEMBRANE PROTEIN; MICRORNA 21; PROGRAMMED CELL DEATH 4 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ETS 1; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; ETS1 PROTEIN, HUMAN; HISTONE; ITGB4 PROTEIN, HUMAN; MICRORNA; MIRN21 MICRORNA, HUMAN; PDCD4 PROTEIN, HUMAN; RNA BINDING PROTEIN; TUMOR MARKER;

ARTICLE; CANCER PROGNOSIS; CELL INVASION; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL CANCER; CONTROLLED STUDY; DNA TRANSFECTION; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE TARGETING; HISTONE MODIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; METASTASIS POTENTIAL; PROMOTER REGION; RECEIVER OPERATING CHARACTERISTIC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; WESTERN BLOTTING; COLORECTAL TUMOR; GENE REGULATORY NETWORK; GENETIC EPIGENESIS; GENETICS; METABOLISM; METASTASIS; PATHOLOGY; PROTEIN PROCESSING; TUMOR CELL LINE;

APOPTOSIS REGULATORY PROTEINS; BIOMARKERS, TUMOR; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; EPIGENESIS, GENETIC; EPITHELIAL-MESENCHYMAL TRANSITION; GENE REGULATORY NETWORKS; HISTONES; HUMANS; INTEGRIN BETA4; MICRORNAS; NEOPLASM METASTASIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEIN C-ETS-1; RNA-BINDING PROTEINS; TRANSCRIPTION FACTOR AP-1;

EID: 84891915416     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.26842     Document Type: Article

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