Determination of pterins in urine by HPLC with UV and fluorescent detection using different types of chromatographic stationary phases (HILIC, RP C8, RP C18)

Journal of Pharmaceutical and Biomedical Analysis

Volumn 91, Issue , 2014, Pages 37-45

  Kośliński, Piotr ^a   Jarzemski, Piotr ^b   Markuszewski, Michał J ^c   Kaliszan, Roman ^c  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^b Department of Urology Dr Jan Biziel University Hospital No 2 in Bydgoszcz   (Poland)

^c MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Biomarkers; Bladder cancer; HILIC; Pterin; Reversed phase HPLC

Indexed keywords

6 HYDROXY METHYLPTERIN; 6,7 DIMETHYLPTERIN; BIOPTERIN; BUFFER; ISOXANTHOPTERIN; NEOPTERIN; PTERIN; PTERIN DERIVATIVE; UNCLASSIFIED DRUG; XANTHOPTERIN;

ACCURACY; ARTICLE; BLADDER CANCER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELUTION; FLOW KINETICS; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIMIT OF DETECTION; MEASUREMENT REPEATABILITY; OXIDATION; OXIDATION KINETICS; PH; PHASE TRANSITION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; ULTRAVIOLET RADIATION; URINALYSIS; URINE; VALIDATION PROCESS;

BIOMARKERS; BLADDER CANCER; HILIC; PTERIN; REVERSED PHASE HPLC;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; FLUORESCENCE; HUMANS; HYDROGEN-ION CONCENTRATION; LIMIT OF DETECTION; PTERINS; ULTRAVIOLET RAYS;

EID: 84891908343     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.12.012     Document Type: Article

References (19)

1. Murata S., Ichinose H., Urano F. Tetrahydrobiopterin and related biologically important pterins. Top. Heterocycl. Chem. 2007, 8:127-171.
2. Ma Y., Liu G., Du M., Stayton I. Recent developments in the determination of urinary cancer biomarkers by capillary electrophoresis. Electrophoresis 2004, 25:1473-1484.
3. Espinosa-Mansilla A., Muñoz de la Peña A., Cañada-Cañada F., Mancha de Lianos A. LC determination of biopterin reduced forms by UV-photogeneration of biopterin and fluorimetric detection. Talanta 2008, 77:844-851.
4. Weiss G., Kronberger P., Conrad F., Bodner E., Wachter H., Reibnegger G. Neopterin and prognosis in patients with adenocarcinoma of the colon. Cancer Res. 1993, 53:260-265.
5. Murr C.H., Bergant A., Widschwendter M., Heim K., Schröcksnadel H., Fuchs D. Neopterin is an independent prognostic variable in females with breast cancer. Clin. Chem. 1999, 45:1998-2004.
6. Melichar B., Solichová D., Svobodová I., Urbánek L., Vesely P., Melicharová K. Urinary neopterin in patients with liver tumors. Tumori 2006, 92:318-322.
7. Gibbons S.E., Stayton I., Ma Y. Optimization of urinary pteridine analysis conditions by CE-LIF for clinical use in early cancer detection. Electrophoresis 2009, 30:3591-3597.
8. Kośliński P., Bujak R., Daghir E., Markuszewski M.J. Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases. Electrophoresis 2011, 32:2044-2054.
9. Cañada-Cañada F., Espinosa-Mansilla A., De La Peña A.M., De Lianos A.M. Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method. Anal. Chim. Acta 2009, 648:113-122.
10. Espinosa Mansilla A., Durán Merás I., Salinas F. Analysis of pteridines and creatinine in urine by HPLC with serial fluorimetric and photometric detectors. Chromatographia 2001, 53:510-514.
11. Buszewski B., Noga S. Hydrophilic interaction liquid chromatography (HILIC)-a powerful separation technique. Anal. Bioanal. Chem. 2012, 402:231-247.
12. Quiming N.S., Denola N.L., Soliev A.B., Saito Y., Jinno K. Retention behavior of ginsenosides on a poly(vinyl alcohol)-bonded stationary phase in hydrophilic interaction chromatography. Anal. Bioanal. Chem. 2007, 389:1477-1488.
13. Hemstrom P., Irgum K. Hydrophilic interaction chromatography. J. Sep. Sci. 2006, 29:1784-1821.
14. Li R., Huang J. Chromatographic behavior of epirubicin and its analogues on high-purity silica in hydrophilic interaction chromatography. Chromatogr. A 2004, 1041:163-169.
15. Lorente C., Thomas A.H. Photophysics and photochemistry of pterins in aqueous solution. Acc. Chem. Res. 2006, 39:395-402.
16. Guo Y., Gaiki S. Retention behavior of small polar compounds on polar stationary phases in hydrophilic interaction chromatography. J. Chromatogr. A 2005, 1074:71-80.
17. de Lianos A.M., Espinosa-Mansilla A., Canada-Canada F., de la Pena A.M. Separation and determination of 11 marker pteridines in human urine by liquid chromatography and fluorimetric detection. J. Sep. Sci. 2011, 34:1283-1292.
18. Gamagedra S., Gibbson S., Ma Y. Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer. Clin. Chim. Acta 2011, 412:120-128.
19. Han F., Huynh B.H., Shi H., Lin B., Ma Y. Pteridine analysis in urine by capillary electrophoresis using laser-induced fluorescence detection. Anal. Chem. 1999, 71:1265-1269.