Myeloperoxidase in the neurodegenerative process of Parkinson's disease;Neurodegenerativer Prozess bei Morbus Parkinson: Rolle der Myeloperoxidase

Deutsche Medizinische Wochenschrift

Volumn 139, Issue 3, 2014, Pages 99-102

  Teismann, P ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Aastrocytes; gliosis; MPTP; myeloperoxidase; neurodegeneration; neutrophils; Parkinson's disease

Indexed keywords

MYELOPEROXIDASE;

DEGENERATIVE DISEASE; NERVE DEGENERATION; PARKINSON DISEASE; REVIEW;

EID: 84891879609     PISSN: 00120472     EISSN: 14394413     Source Type: Journal    
DOI: 10.1055/s-0033-1359907     Document Type: Review

References (11)

1. Choi D. K., Pennathur S., Perier C. et al. Ablation of the inflammatory enzyme myeloperoxidase mitigates features of parkinson's disease in mice. J Neurosci: 2005; 25 6594 6600
2. Forno L. S., DeLanney L. E., Irwin I. et al. Astrocytes and parkinson's disease. Prog Brain Res: 1992; 94 429 436
3. Gaut J. P., Yeh G. C., Tran H. D. et al. Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proc Natl Acad Sci USA: 2001; 98 11961 11966
4. Huh S. H., Chung Y. C., Piao Y. et al. Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of parkinson's disease. J Immunol: 2011; 187 960 969
5. Lau D., Mollnau H., Eiserich J. P. et al. Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc Natl Acad Sci U S A: 2005; 102 431 436
6. Liberatore G., Jackson-Lewis V., Vukosavic S. et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of parkinson's disease. Nat Med: 1999; 5 1403 1409
7. Malle E., Furtmuller P. G., Sattler W. et al. Myeloperoxidase: A target for new drug development? Br J Pharmacol: 2007; 152 838 854
8. Pennathur S., Jackson-Lewis V., Przedborski S. et al. Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine and O,O'-dityrosine in brain tissue of MPTP-treated mice, a model of oxidative stress in parkinson's disease. J Biol Chem: 1999; 274 34621 34628
9. van der Vliet A., Eiserich J. P., Halliwell B. et al. Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicity. J Biol Chem: 1997; 272 7617 7625
10. Wu D. C., Teismann P., Tieu K. et al. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinson's disease. Proc Natl Acad Sci U S A: 2003; 100 6145 6150
11. Astra Zeneca Investigating safety, tolerability and pk when giving single and fractionated doses of AZD3241 to healthy volunteers. http://www. astrazenecaclinicaltrials.com/diseases-and-conditions/diseaseandconditions/? itemId=8595333 Letzter Zugriff: 12.11.2013