Proton radiotherapy for pediatric central nervous system ependymoma: Clinical outcomes for 70 patients

Neuro-Oncology

Volumn 15, Issue 11, 2013, Pages 1552-1559

  Mac Donald, Shannon M ^a   Sethi, Roshan ^a   Lavally, Beverly ^a   Yeap, Beow Y ^a   Marcus, Karen J ^b   Caruso, Paul ^a   Pulsifer, Margaret ^a   Huang, Mary ^a   Ebb, David ^a   Tarbell, Nancy J ^a   Yock, Torunn I ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Centralnervoussystem; Pediatric ependymoma; Proton; Radiation

Indexed keywords

CARBOPLATIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; GROWTH HORMONE; THYROID HORMONE; VINCRISTINE;

ADOLESCENT; ADULT; ARTICLE; BRAIN CANCER; CANCER CHEMOTHERAPY; CANCER SIZE; CANCER SURVIVAL; CERVICAL SPINE DISLOCATION; CHILD; CHILDHOOD CANCER; COGNITION; COHORT ANALYSIS; EPENDYMOMA; FEMALE; FOLLOW UP; GROWTH HORMONE DEFICIENCY; HEARING IMPAIRMENT; HUMAN; HYPOTHYROIDISM; INFANT; INTELLIGENCE; MAJOR CLINICAL STUDY; MALE; MINIMAL RESIDUAL DISEASE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PATIENT SELECTION; PRESCHOOL CHILD; PROGRESSION FREE SURVIVAL; PROTON THERAPY; RADIATION DOSE; RADIATION INJURY; SCHOOL CHILD; SKILL; TUMOR NECROSIS; YOUNG ADULT;

CENTRAL NERVOUS SYSTEM; PEDIATRIC EPENDYMOMA; PROTON; RADIATION;

BRAIN NEOPLASMS; CENTRAL NERVOUS SYSTEM; EPENDYMOMA; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PROTON THERAPY; TREATMENT OUTCOME;

EID: 84891872341     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/not121     Document Type: Article

References (30)

1. Central Brain Tumor Registry of the United States. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004-2008 (March 23, 2012 Revision). Hinsdale, IL: Author; 2012
2. Phi JH, Wang KC, Park SH, et al. Pediatric infratentorial ependymoma: prognostic significance of anaplastic histology. J Neurooncol. 2012;106(3):619-626
3. Perilongo G, Massimino M, Sotti G, et al. Analyses of prognostic factors in a retrospective review of 92 children with ependymoma: Italian Pediatric Neuro-oncology Group. Med Pediatr Oncol. 1997;29(2):79-85
4. Merchant TE. Three-dimensional conformal radiation therapy for ependymoma. Childs Nerv Syst. 2009;25(10):1261-1268
5. Mansur DB, Perry A, Rajaram V, et al. Postoperative radiation therapy for grade II and III intracranial ependymoma. Int J Radiat Oncol Biol Phys. 2005;61(2):387-391
6. Koshy M, Rich S, Merchant TE, Mahmood U, Regine WF, Kwok Y. Post-operative radiation improves survival in children younger than 3 years with intracranial ependymoma. J Neurooncol. 2011;105(3):583-590
7. Schild SE, Nisi K, Scheithauer BW, et al. The results of radiotherapy for ependymomas: the Mayo Clinic experience. Int J Radiat Oncol Biol Phys. 1998;42(5):953-958
8. Shu HK, Sall WF, Maity A, et al. Childhood intracranial ependymoma: twenty-year experience from a single institution. Cancer. 2007;110(2): 432-441
9. Timmermann B, Kortmann RD, Kuhl J, et al. Combined postoperative irradiation and chemotherapy for anaplastic ependymomas in childhood: results of the German prospective trials HIT 88/89 and HIT 91. Int J Radiat Oncol Biol Phys. 2000;46(2):287-295
10. Merchant TE, Li C, Xiong X, Kun LE, Boop FA, Sanford RA. Conformal radiotherapy after surgery for paediatric ependymoma: A prospective study. Lancet Oncol. 2009;10(3):258-266
11. Oya N, Shibamoto Y, Nagata Y, Negoro Y, Hiraoka M. Postoperative radiotherapy for intracranial ependymoma: analysis of prognostic factors and patterns of failure. J Neurooncol. 2002;56(1):87-94
12. Merchant TE, Haida T,WangMH, Finlay JL, Leibel SA. Anaplastic ependymoma: treatment of pediatric patients with or without craniospinal radiation therapy. J Neurosurg. 1997;86(6):943-949
13. Merchant TE, Fouladi M. Ependymoma: new therapeutic approaches including radiation and chemotherapy. J Neurooncol. 2005;75(3):287-299
14. Needle MN, Molloy PT, Geyer JR, et al. Phase II study of daily oral etoposide in children with recurrent brain tumors and other solid tumors. Med Pediatr Oncol. 1997;29(1):28-32
15. Timmermann B, Kortmann RD, Kuhl J, et al. Role of radiotherapy in anaplastic ependymoma in children under age of 3 years: Results of the prospective German brain tumor trials HIT-SKK 87 and 92. Radiother Oncol. 2005;77(3):278-285
16. Zacharoulis S, Levy A, Chi SN, et al. Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stemcell rescue. Pediatr Blood Cancer. 2007;49(1):34-40
17. MacDonald SM, Safai S, Trofimov A, et al. Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons. Int J Radiat Oncol Biol Phys. 2008;71(4):979-986
18. America ELSaLCo. Endocrinology Expected Values & S.I. Unit Conversion Tables. In: Services, EL, ed. Calabasas Hills, CA, USA: Esoterix, LabCorp; 2010
19. Jaing TH,Wang HS, Tsay PK, et al. Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas. J Neurooncol. 2004;68(3):255-261
20. Morris EB, Li C, Khan RB, et al. Evolution of neurological impairment in pediatric infratentorial ependymoma patients. J Neurooncol. 2009;94(3):391-398
21. Goldwein JW, Leahy JM, Packer RJ, et al. Intracranial ependymomas in children. Int J Radiat Oncol Biol Phys. 1990;19(6):1497-1502
22. Mack SC, Taylor MD. The genetic and epigenetic basis of ependymoma. Childs Nerv Syst. 2009;25(10):1195-1201
23. Hancock SL, McDougall IR, Constine LS. Thyroid abnormalities after therapeutic external radiation. Int J Radiat Oncol Biol Phys. 1995;31(5):1165-1170
24. Merchant TE, Goloubeva O, Pritchard DL, et al. Radiation dose-volume effects on growth hormone secretion. Int J Radiat Oncol Biol Phys.2002;52(5):1264-1270
25. Rappaport R, Brauner R. Growth and endocrine disorders secondary to cranial irradiation. Pediatr Res. 1989;25(6):561-567
26. Merchant TE, Rose SR, Bosley C, Wu S, Xiong X, Lustig RH. Growth hormone secretion after conformal radiation therapy in pediatric patients with localized brain tumors. J Clin Oncol. 2011;29(36):4776-4780
27. Di Pinto M, Conklin HM, Li C, Xiong X, Merchant TE. Investigating verbal and visual auditory learning after conformal radiation therapy for childhood ependymoma. Int J Radiat Oncol Biol Phys. 2010;77(4):1002-1008
28. Conklin HM, Li C, Xiong X, Ogg RJ, Merchant TE. Predicting change in academic abilities after conformal radiation therapy for localized ependymoma. J Clin Oncol. 2008;26(24):3965-3970
29. Merchant TE, Mulhern RK, Krasin MJ, et al. Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiationrelated CNS effects for pediatric patients with localized ependymoma. J Clin Oncol. 2004;22(15):3156-3162
30. Merchant TE, Kiehna EN, Li C, Xiong X, Mulhern RK. Radiation dosimetry predicts IQ after conformal radiation therapy in pediatric patients with localized ependymoma. Int J Radiat Oncol Biol Phys. 2005;63(5): 1546-1554