GSTM1 gene expression correlates to leiomyoma volume regression in response to mifepristone treatment

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Engman, Mikael ^a   Varghese, Suby ^a   Robinson, Kristina Lagerstedt ^a   Malmgren, Helena ^a   Hammarsjö, Anna ^a   Byström, Birgitta ^a   Lalitkumar, Parameswaran Grace L ^a   Gemzell Danielsson, Kristina ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE M1; MIFEPRISTONE; RNA;

ARTICLE; CANCER INHIBITION; CLINICAL ARTICLE; CONTROLLED STUDY; ESR1 GENE; FEMALE; GENE; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; GSTM1 GENE; GSTM3 GENE; GSTM5 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MKI67 GENE; PAK3 GENE; PGR GENE; TP53 GENE; TUMOR VOLUME; UTERUS MYOMA;

BIOLOGICAL MARKERS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE TRANSFERASE; HORMONE ANTAGONISTS; HUMANS; LEIOMYOMA; MIFEPRISTONE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREMENOPAUSE; RECEPTORS, PROGESTERONE; SIGNAL TRANSDUCTION; TUMOR BURDEN; UTERINE NEOPLASMS; UTERUS;

EID: 84891870838     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080114     Document Type: Article

References (25)

1. Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM (2003) High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence. Am J Obstet Gynecol Volume 188: 100-107.
2. Wise LA, Palmer JR, Spiegelman D, Harlow BL, Stewart EA, et al. (2005) Influence of body size and body fat distribution on risk of uterine leiomyomata in U.S. black women. Epidemiology 16: 346-354.
3. Flynn M, Jamison M, Datta S, Myers E (2006) Health care resource use for uterine fibroid tumors in the United States. Am J Obstet Gynecol 195: 955-964.
4. Wilson EA, Yang F, Rees ED (1980) Estradiol and progesterone binding in uterine leiomyomata and in normal uterine tissues. Obstet Gynecol 55: 20-24.
5. Bagaria M, Suneja A, Vaid NB, Guleria K, Mishra K (2009) Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial. Aust N Z J Obstet Gynaecol 49: 77-83.
6. Engman M, Granberg S, Williams AR, Meng CX, Lalitkumar PG, et al. (2009) Mifepristone for treatment of uterine leiomyoma. A prospective randomized placebo controlled trial. Hum Reprod.
7. Donnez J, Tomaszewski J, Vazquez F, Bouchard P, Lemieszczuk B, et al. (2012) Ulipristal acetate versus leuprolide acetate for uterine fibroids. N Engl J Med 366: 421-432.
8. Donnez J, Tatarchuk TF, Bouchard P, Puscasiu L, Zakharenko NF, et al. (2012) Ulipristal acetate versus placebo for fibroid treatment before surgery. N Engl J Med 366: 409-420.
9. Bouchard P, Chabbert-Buffet N, Fauser BC (2011) Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety. Fertil Steril 96: 1175-1189.
10. Chabbert-Buffet N, Pintiaux A, Bouchard P (2012) The immninent dawn of SPRMs in obstetrics and gynecology. Mol Cell Endocrinol 358: 232-243.
11. Bouchard P (2011) Current and future medical treatments for menometrorrhagia during the premenopause. Gynecol Endocrinol 27 Suppl 1: 1120-1125.
12. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
13. Groppi A, Coutelle C, Fleury B, Iron A, Begueret J, et al. (1991) Glutathione S-transferase class mu in French alcoholic cirrhotic patients. Hum Genet 87: 628-630.
14. Seidegard J, Pero RW, Markowitz MM, Roush G, Miller DG, et al. (1990) Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis 11: 33-36.
15. Zhong S, Wyllie AH, Barnes D, Wolf CR, Spurr NK (1993) Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis 14: 1821-1824.
16. Harada S, Misawa S, Nakamura T, Tanaka N, Ueno E, et al. (1992) Detection of GST1 gene deletion by the polymerase chain reaction and its possible correlation with stomach cancer in Japanese. Hum Genet 90: 62-64.
17. Hadfield RM, Manek S, Weeks DE, Mardon HJ, Barlow DH, et al. (2001) Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1. Mol Hum Reprod 7: 1073-1078.
18. Hsieh YY, Chang CC, Tsai FJ, Lin CC, Chen JM, et al. (2004) Glutathione S-transferase M1*null genotype but not myeloperoxidase promoter G-463A polymorphism is associated with higher susceptibility to endometriosis. Mol Hum Reprod 10: 713-717.
19. Baranova H, Bothorishvilli R, Canis M, Albuisson E, Perriot S, et al. (1997) Glutathione S-transferase M1 gene polymorphism and susceptibility to endometriosis in a French population. Mol Hum Reprod 3: 775-780.
20. Huang PC, Tsai EM, Li WF, Liao PC, Chung MC, et al. Association between phthalate exposure and glutathione S-transferase M1 polymorphism in adenomyosis, leiomyoma and endometriosis. Hum Reprod 25: 986-994.
21. Mesquita FS, Dyer SN, Heinrich DA, Bulun SE, Marsh EE, et al. Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells. Biol Reprod 82: 341-351.
22. Lee TD, Yang H, Whang J, Lu SC (2005) Cloning and characterization of the human glutathione synthetase 5′-flanking region. Biochem J 390: 521-528.
23. Murphy AA, Zhou MH, Malkapuram S, Santanam N, Parthasarathy S, et al. (2000) RU486-induced growth inhibition of human endometrial cells. Fertil Steril 74: 1014-1019.
24. Wu X, Blanck A, Olovsson M, Moller B, Favini R, et al. (2000) Apoptosis, cellular proliferation and expression of p53 in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause. Acta Obstet Gynecol Scand 79: 397-404.
25. Engman M, Skoog L, Soderqvist G, Gemzell-Danielsson K (2008) The effect of mifepristone on breast cell proliferation in premenopausal women evaluated through fine needle aspiration cytology. Hum Reprod 23: 2072-2079.