Ten nights of moderate hypoxia improves insulin sensitivity in obese humans

Diabetes Care

Volumn 36, Issue 12, 2013, Pages

  Lecoultre, Virgile ^a,b   Peterson, Courtney M ^a   Covington, Jeffrey D ^a   Ebenezer, Philip J ^a   Frost, Elizabeth A ^a   Schwarz, Jean Marc ^c   Ravussin, Eric ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c Touro University California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; OXYGEN;

ADIPOSE TISSUE; ADULT; CALORIMETRY; CLINICAL ARTICLE; DIABETIC OBESITY; DISEASE SEVERITY; GLUCOSE TRANSPORT; HUMAN; HYPOXIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LETTER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; ANIMAL; ANOXIA; BLOOD; FOLLOW UP; NORMAL HUMAN; OBESITY; PROCEDURES; RESPIRATORY CARE;

ADULT; ANIMALS; ANOXIA; FOLLOW-UP STUDIES; HEALTHY VOLUNTEERS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; OBESITY; OXYGEN; RESPIRATORY THERAPY;

EID: 84891853091     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc13-1350     Document Type: Letter

References (7)

1. Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev 2013;93:1-21
2. Santos JL, Pérez-Bravo F, Carrasco E, Calvillán M, Albala C. Low prevalence of type 2 diabetes despite a high average body mass index in the Aymara natives from Chile. Nutrition 2001;17:305-309
3. Azevedo JL Jr, Carey JO, Pories WJ, Morris PG, Dohm GL. Hypoxia stimulates glucose transport in insulin-resistant human skeletal muscle. Diabetes 1995;44:695-698
4. Mackenzie R, Maxwell N, Castle P, Elliott B, Brickley G, Watt P. Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. J Clin Endocrinol Metab 2012;97:E546-E555
5. Pasarica M, Sereda OR, Redman LM, et al. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 2009;58:718-725
6. Henry RR, Abrams L, Nikoulina S, Ciaraldi TP. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures. Diabetes 1995;44:936-946
7. Cartee GD, Douen AG, Ramlal T, Klip A, Holloszy JO. Stimulation of glucose transport in skeletal muscle by hypoxia. J Appl Physiol 1991;70:1593-1600